CAS 136572-09-3: Clorhidrato de irinotecán trihidrato

Descripción: Clorhidrato de irinotecán trihidrato es un agente quimioterapéutico utilizado principalmente en el tratamiento del cáncer colorrectal. Es una sal soluble en agua derivada del alcaloide natural camptotecina y funciona como un inhibidor de la topoisomerasa I, interrumpiendo la replicación y transcripción del ADN en las células cancerosas. La sustancia aparece como un polvo cristalino blanco a blanco sucio y es higroscópica, lo que significa que puede absorber humedad del ambiente. Su fórmula molecular incluye un componente de clorhidrato y tres moléculas de agua, lo que contribuye a su estabilidad y solubilidad en soluciones acuosas. El irinotecán se administra por vía intravenosa y a menudo se utiliza en combinación con otros agentes quimioterapéuticos para mejorar la eficacia. Los efectos secundarios comunes incluyen diarrea, náuseas y mielosupresión, lo que requiere un monitoreo cuidadoso durante el tratamiento. La farmacocinética del compuesto implica un metabolismo principalmente por el hígado, con metabolitos activos que contribuyen a sus efectos terapéuticos y toxicidad. En general, Clorhidrato de irinotecán trihidrato desempeña un papel significativo en oncología, particularmente en el manejo de cánceres en etapas avanzadas.

Fórmula: C₃₃H₃₈N₄O₆·ClH·3H₂O

InChI: InChI=1S/C33H38N4O6.ClH.3H2O/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;;;;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H;3*1H2/t33-;;;;/m0..../s1

Clave InChI: InChIKey=KLEAIHJJLUAXIQ-JDRGBKBRSA-N

SMILES: Cl.O=C(OC=1C=CC2=NC=3C4=CC5=C(C(=O)N4CC3C(=C2C1)CC)COC(=O)C5(O)CC)N6CCC(N7CCCCC7)CC6.O

Sinónimos:

• (+)-7-Ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, monohydrochloride, trihydrate
• (+)-7-Ethyl-10-hydroxycamptothecine 10-(1,4'-bipiperidine)-1'-carboxylate, monohydrochloride, trihydrate
• (1,4'-Bipiperidine)-1'-Carboxylicacid,4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hyd Monohydrochloride, Trihydrate
• (1,4'-Bipiperidine)-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester, monohydrochloride, trihydrate, (S)-
• (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl [1,4'-bipiperidine]-1'-carboxylate trihydrate hydrochloride
• (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate
• (S)-[1,4'-Bipiperidine]-1'-Carboxylic Acid 4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1H-Pyrano
• (S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline, [1,4′-bipiperidine]-1′-carboxylic acid deriv.
• Camptosar
• Irinotecan HCl trihydrate
• Irinotecan Monohydrochloride Trihydrate
• Irinotecan hydrochloride hydrate
• Irinotecanhydrochloridetrihydrate(Cpt-11)
• Onivyde
• Onivyde pegylated liposomal
• Roxy-3,14-Dioxo-1H-Pyrano(3',4',6,7)Indolizino(1,2-B)Quinolin-9-Ylester,Mono
• Trihydrate,(S)-Hydrochlorid Trihydrate
• [1,4'-Bipiperidine]-1'-Carboxylic Acid (S)-4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1H-Pyrano
• [1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, hydrochloride, hydrate (1:1:3)
• [1,4′-Bipiperidine]-1′-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, hydrochloride, hydrate (1:1:3)
• [1,4′-Bipiperidine]-1′-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride, trihydrate
• [1,4′-Bipiperidine]-1′-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride, trihydrate, (S)-
• [3',4',6,7]Indolizino[1,2-B]Quinolin-9-Yl Ester, Hcl Trihydrate
• [3',4':6,7]Indolizino[1,2-B]Quinolin-9-Yl Ester Hydrochloride Trihydrate

Irinotecan Hydrochloride Trihydrate

CAS: 100286-90-6 136572-09-397682-44-5

• Fórmula: C₃₃H₃₈N₄O₆·HCl·3H₂O
• Pureza: >98.0%(T)(HPLC)
• Forma y color: White to Orange to Green powder to crystal
• Peso molecular: 677.20

Irinotecan hydrochloride trihydrate, 99%

CAS: 136572-09-3

Topoisomerase I inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa …

• Fórmula: C₃₃H₄₅ClN₄O₉
• Pureza: 99%
• Peso molecular: 677.19

Irinotecan for system suitability 1 CRS

CAS: 136572-09-3

Irinotecan for system suitability 2 CRS

CAS: 136572-09-3

• Fórmula: C₃₃H₃₈N₄O₆
• Forma y color: Powder. Yellow. Light Yellow.
• Peso molecular: 586.678

Irinotecan for peak identification CRS

CAS: 136572-09-3

• Fórmula: C₃₃H₃₈N₄O₆
• Forma y color: Powder. Yellow. Light Yellow.
• Peso molecular: 586.678

Irinotecan hydrochloride trihydrate CRS

CAS: 136572-09-3

• Fórmula: C₃₃H₃₈N₄O₆
• Forma y color: Powder. Yellow. Light Yellow.
• Peso molecular: 586.678

Irinotecan Hydrochloride

CAS: 136572-09-3

Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoi

• Fórmula: C₃₃H₃₈N₄O₆·HCl· 3H₂O
• Forma y color: Pale Yellow Yellow Powder
• Peso molecular: 586.27913

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

• Fórmula: C₃₃H₄₅ClN₄O₉
• Pureza: 98%
• Forma y color: Solid
• Peso molecular: 677.1848

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.

• Fórmula: C₃₃H₄₅ClN₄O₉
• Pureza: 98.22% - 99.79%
• Forma y color: Pale Yellow To Yellow Crystalline Powder
• Peso molecular: 677.18

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

• Pureza: 98.37%
• Peso molecular: 677.18g/mol

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

• Fórmula: C₃₃H₃₈N₄O₆·HCl· 3(H₂O)
• Pureza: ≥ 99.0% (anhydrous)
• Forma y color: Off-white to yellow crystalline powder
• Peso molecular: 623.14 (anhydrous)

Irinotecan Hydrochloride Trihydrate

CAS: 136572-09-3

• Pureza: 98%
• Peso molecular: 677.18g/mol

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Fórmula: C₃₃H₄₅ClN₄O₉
• Forma y color: Powder, Yellow
• Peso molecular: 677.19

Irinotecan Hydrochloride Trihydrate

CAS: 136572-09-3

• Fórmula: C₃₃H₃₈N₄O₆·ClHH₂O
• Forma y color: Light Yellow
• Peso molecular: 677.18

Irinotecan Hydrochloride Trihydrate

CAS: 136572-09-3

Applications Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor. References Kunimoto, T., et al.: Cancer …

• Fórmula: C₃₃H₃₈N₄O₆·ClHH₂O
• Forma y color: Light Yellow
• Peso molecular: 677.18

Irinotecan, Hydrochloride Salt

CAS: 136572-09-3

• Pureza: 98.0%
• Forma y color: Solid
• Peso molecular: 623.1500244140625

Irinotecan hydrochloride trihydrate - Bio-X ™

CAS: 136572-09-3

Irinotecan hydrochloride trihydrate is a topoisomerase I inhibitor that is used as chemotherapy drug for …

• Fórmula: C₃₃H₃₈N₄O₆•HCl•(H₂O)₃
• Pureza: Min. 95%
• Forma y color: Powder
• Peso molecular: 677.18 g/mol

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

Inhibitor of DNA topoisomerase I

• Fórmula: C₃₃H₃₈N₄O₆•HCl•(H₂O)₃
• Pureza: Min. 97 Area-%
• Forma y color: Yellow Powder
• Peso molecular: 677.18 g/mol

(R)-Irinotecan Hydrochloride-d10 Trihydrate

CAS: 1255644-71-3 136572-09-3

• Fórmula: C₃₃H₃₅D₁₀ClN₄O₉
• Forma y color: Neat
• Peso molecular: 687.25

(R)-Irinotecan Hydrochloride Trihydrate

CAS: 1255644-71-3 136572-09-31992961-26-8

• Fórmula: C₃₃H₃₈N₄O₆·HCl· 3H₂O
• Forma y color: Neat
• Peso molecular: 677.21