CAS 136834-22-5
:2'-Fluoro-N6-Bz-5'-O-DMT-2'-desoxiadenosina-3'-CE-Fosforamidita
Descripción:
2'-Fluoro-N6-Bz-5'-O-DMT-2'-desoxiadenosina-3'-CE-Fosforamidita es un análogo de nucleósido modificado utilizado principalmente en el campo de la síntesis de oligonucleótidos. Este compuesto presenta una modificación de 2'-fluoro, que mejora la estabilidad y la afinidad de unión del nucleósido, haciéndolo particularmente útil en el desarrollo de oligonucleótidos antisentido y otras aplicaciones terapéuticas. El grupo N6-benzoyl (Bz) actúa como un moiety protector para el grupo amino, mientras que el grupo 5'-O-DMT (dimetoxitrileno) protege el hidroxilo 5', facilitando la adición escalonada de nucleótidos durante la síntesis. La funcionalidad de fosforamidito 3'-CE (cianoetilo) permite la formación de enlaces fosfodiéster, esenciales para la construcción de cadenas de ácidos nucleicos. En general, este compuesto se caracteriza por su estabilidad mejorada, especificidad y utilidad en la investigación de ácidos nucleicos y el desarrollo terapéutico, lo que lo convierte en una herramienta valiosa en biología molecular e ingeniería genética.
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Encontrado 10 productos.
DMT-2'-Fluoro-dA(Bz) Phosphoramidite
CAS:Fórmula:C47H51FN7O7PPureza:>90.0%(qNMR)Forma y color:White to Light yellow powder to crystalPeso molecular:875.94N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-(2-cyanoethyl diisopropylphosphoramidite), 98%
CAS:<p>This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci</p>Fórmula:C47H51FN7O7PPureza:98%Forma y color:White to off-white, Powder or crystals or crystalline powder or flakesPeso molecular:875.94Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
CAS:Fórmula:C47H51FN7O7PPureza:95%Forma y color:SolidPeso molecular:875.9227Ref: IN-DA0012FC
1g72,00€5g167,00€10g200,00€1kgA consultar25g528,00€50mgA consultar100mg35,00€250mg54,00€500mg68,00€(2R,3R,4R,5R)-5-(6-Benzamido-9H-Purin-9-Yl)-2-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Fluorotetrahydrofuran-3-Yl (2-Cyanoethyl) Diisopropylphosphoramidite
CAS:(2R,3R,4R,5R)-5-(6-Benzamido-9H-Purin-9-Yl)-2-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Fluorotetrahydrofuran-3-Yl (2-Cyanoethyl) DiisopropylphosphoramiditePureza:98%Peso molecular:875.92g/molDmt-2'fluoro-da(bz) amidite
CAS:<p>DMT-2'Fluoro-DA(Bz) amidite: 2'-deoxy-2'-fluoro oligo with RNA affinity; precursor to antisense 5'-DMT-3'-phosphoramidite.</p>Fórmula:C47H51FN7O7PPureza:98.15%Forma y color:SolidPeso molecular:875.92N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine 3'-CE phosphoramidite
CAS:Nucleoside phosphoramidites are used in the chemical synthesis of oligonucleotides. N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine 3'-CE phosphoramidite, also known as 2'-fluoro-dA CEP, is a modified adenosine with a fluorine atom in the 2’ position to enable the synthesis of non-natural fluorine containing oligonucleotides. Nucleoside phosphoramidites are typically modified by displacement of the diisopropylamine group with the 5’ hydroxyl of the next nucleoside in the presence of an azole catalyst such as 1H-tetrazole or 4,5-dicyanoimidazole. 2'-Fluoro-dA CEP has been used in the synthesis of phosphorothioate oligonucleotides that were highly nuclease resistant yet retained exceptional binding affinity to the RNA targets.Fórmula:C47H51FN7O7PPureza:97%Forma y color:PowderPeso molecular:875.95 g/molRef: 4Z-A-267081
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