CAS 137234-62-9

Voriconazol

Descripción:

Voriconazol es un medicamento antifúngico que se utiliza principalmente para tratar infecciones fúngicas graves, particularmente aquellas causadas por especies de Aspergillus y Candida. Pertenece a la clase de antifúngicos triazoles, que funcionan inhibiendo la enzima lanosterol 14α-demetilasa, crucial para la síntesis de ergosterol en las membranas celulares fúngicas. Voriconazol se caracteriza por su actividad de amplio espectro contra varios hongos, lo que lo hace efectivo en infecciones invasivas y no invasivas. El compuesto se administra típicamente por vía oral o intravenosa y es conocido por su buena biodisponibilidad y penetración en los tejidos. Su farmacocinética puede verse influenciada por factores como la edad, la función hepática y los medicamentos concurrentes, lo que requiere un monitoreo cuidadoso de los niveles del fármaco en algunos pacientes. Voriconazol también se asocia con efectos secundarios potenciales, incluyendo alteraciones visuales, hepatotoxicidad y reacciones cutáneas. Debido a su mecanismo de acción específico y perfil de efectos secundarios, Voriconazol a menudo se reserva para casos en los que otros tratamientos antifúngicos son ineficaces o inapropiados.

Fórmula: C₁₆H₁₄F₃N₅O

InChI: InChI=1/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3

Clave InChI: InChIKey=BCEHBSKCWLPMDN-MGPLVRAMSA-N

SMILES: [C@@]([C@@H](C)C=1C(F)=CN=CN1)(CN2C=NC=N2)(O)C3=C(F)C=C(F)C=C3

Sinónimos:

• (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
• (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
• (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol L(-)-Camphorsulfonate
• (αR,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
• 2-(2,4-Difluorophenyl)-3-(5-Fluoropyrimidin-4-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol
• 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-
• 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, [R-(R*,S*)]-
• Drg 0301
• G-573
• Uk 109496
• Vfend
• Voriconazol
• (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol L(-)-CaMphorsulfonate
• Voriconazole
• UK-10949
• (2R,3S/2S,3R)-3-(5-FLUORO-4-PYRIMIDINYL)-2-(2,4-DIFLUOROPHENYL)-1-(1H-1,2,4-TRIA
• (aR,S)-a-(2,4-Difluorophenyl)-5-fluoro--methyl-a-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol

Voriconazole

CAS: 137234-62-9

Fórmula: C₁₆H₁₄F₃N₅O

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 349.32

Ref: 3B-V0116

Voriconazole

CAS: 137234-62-9

Forma y color: Neat

Ref: 61-FOR1094.00

Voriconazole 2.0 mg/ml in Methanol

CAS: 137234-62-9

Forma y color: Single Solution

Ref: 61-AMP1094.00-07

VORICONAZOLE CRS

CAS: 137234-62-9

VORICONAZOLE CRS

Fórmula: C₁₆H₁₄F₃N₅O

Forma y color: White. Powder.

Peso molecular: 349.3105

Ref: 41-Y0001395

Voriconazole

CAS: 137234-62-9

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Fórmula: C₁₆H₁₄F₃N₅O

Forma y color: White Powder

Peso molecular: 349.11504

Ref: 45-1718008

4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-

CAS: 137234-62-9

Fórmula: C₁₆H₁₄F₃N₅O

Pureza: 99%

Forma y color: Solid

Peso molecular: 349.3105

Ref: IN-DA0012YZ

Voriconazole

CAS: 137234-62-9

Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.

Fórmula: C₁₆H₁₄F₃N₅O

Pureza: 98% - 99.91%

Forma y color: White To Off White Crystalline Powder

Peso molecular: 349.31

Ref: TM-T0120

Voriconazole

CAS: 137234-62-9

Fórmula: C₁₆H₁₄F₃N₅O

Forma y color: White To Off-White Solid

Peso molecular: 349.32

Ref: 4Z-V-101

Voriconazole-d3

CAS: 137234-62-9

Fórmula: C₁₆H₁₁D₃F₃N₅O

Forma y color: White To Off-White Solid

Peso molecular: 352.34

Ref: 4Z-V-1027

Voriconazole

CAS: 137234-62-9

Voriconazole

Pureza: 98%

Peso molecular: 349.31g/mol

Ref: 54-PC109157

Voriconazole

CAS: 137234-62-9

Voriconazole

Pureza: ≥98%

Peso molecular: 349.31g/mol

Ref: 54-BUP17710

Voriconazole

CAS: 137234-62-9

Fórmula: C₁₆H₁₄F₃N₅O

Pureza: 98.0 - 102.0 %

Forma y color: White to off-white crystalline powder

Peso molecular: 349.31

Ref: 7W-GA6306

Voriconazole

Producto controlado

CAS: 137234-62-9

Fórmula: C₁₆H₁₄F₃N₅O

Forma y color: Neat

Peso molecular: 349.31

Ref: 04-C17930000

Voriconazole

Producto controlado

CAS: 137234-62-9

Fórmula: C₁₆H₁₄F₃N₅O

Forma y color: Neat

Peso molecular: 349.31

Ref: 86-MM1094.00

Voriconazole Impurity 4

CAS: 137234-62-9

Fórmula: C₁₆H₁₃ClF₃N₅OHCl

Forma y color: White To Off-White Solid

Peso molecular: 383.76 36.46

Ref: 4Z-V-1017

Voriconazole-d6

CAS: 137234-62-9

Fórmula: C₁₆H₈D₆F₃N₅O

Peso molecular: 355.35

Ref: 4Z-V-1042

Voriconazole-13C-d3

CAS: 137234-62-9

Fórmula: C₁₅₁₃CH₁₁D₃F₃N₅O

Peso molecular: 353.33

Ref: 4Z-V-1044

Voriconazole RS

CAS: 137234-62-9

Forma y color: White Solid Crystalline Powder

Ref: 2K-1153700021

Voriconazole

CAS: 137234-62-9

Voriconazole is an antifungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. This agent also has anti-inflammatory effects and can be used to treat infections caused by Candida glabrata. Voriconazole binds to the cytoplasmic membrane, inhibiting sterol biosynthesis, which leads to cell death. It has been shown to be effective in treating infections caused by Cryptococcus neoformans and Aspergillus fumigatus and is currently being evaluated for its effectiveness against other opportunistic fungal infections such as histoplasmosis. Voriconazole is not active against bacterial or viral infections.

Fórmula: C₁₆H₁₄F₃N₅O

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 349.31 g/mol

Ref: 3D-FV29101

Voriconazole - Bio-X ™

CAS: 137234-62-9

Voriconazole is a synthetic, lipophilic molecule that is used in the treatment of fungal infections. Voriconazole binds to ergosterol which is the major sterol in the cell wall of fungi and inhibits its synthesis, leading to cell death. This drug binds to the enzyme 14α-demethylase allowing the conversion of lanosterol into ergosterol. As a result, this binding leads to the inhibition of ergosterol synthesis, as well as other sterols that are necessary for fungal growth (e.g., squalene).

Fórmula: C₁₆H₁₄F₃N₅O

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 349.31 g/mol

Ref: 3D-BV164532