CAS 1373038-60-8

Impureza B de Valdecoxib

Descripción:

Impureza B de Valdecoxib, identificado por su número CAS 1373038-60-8, es un compuesto químico asociado con el agente farmacéutico valdecoxib, un inhibidor selectivo de COX-2 utilizado para el alivio del dolor y propósitos antiinflamatorios. Como impureza, puede surgir durante la síntesis o degradación del valdecoxib y se caracteriza típicamente por su estructura molecular, que puede diferir ligeramente del compuesto original. Impurezas como Impureza B de Valdecoxib a menudo se evalúan por su posible impacto en la seguridad y eficacia del medicamento. Las características de tales impurezas pueden incluir su solubilidad, estabilidad y reactividad, que son cruciales para entender su comportamiento en formulaciones farmacéuticas. Técnicas analíticas como HPLC (Cromatografía Líquida de Alta Resolución) y espectrometría de masas se emplean comúnmente para identificar y cuantificar impurezas en sustancias farmacéuticas. Las directrices regulatorias exigen la caracterización y control de impurezas para garantizar la calidad y seguridad de los productos farmacéuticos.

Fórmula: C₃₂H₂₅N₃O₆S₂

Sinónimos:

• 4-(5-Methyl-3-phenylisoxazol-4-yl)-N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)benzenesulfonamide (Palbociclib Impurity)
• Valdecoxib DiMer,Valdecoxib IMpurity B
• Parecoxib Impurity 13
• BenzenesulfonaMide, 4-(5-Methyl-3-phenyl-4-isoxazolyl)-N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-
• 4-(5-methyl-3-phenylisoxazol-4-yl)-N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)benzenesulfonamide
• 4-(5-methyl-3-phenylisoxazol-4-yl)-N-((4-(5-
• Parecoxib impurity 6/Valdecoxib Dimer/4-(5-methyl-3-phenylisoxazol-4-yl)-N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)benzenesulfonamide
• Valdecoxib DiMer
• Valdecoxib IMpurity B
• Parecoxib Sodium Impurity 13
• (Valdecoxib IMpurity B)
• N-[4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonyl]-4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonaMide
• 4-(5-Methyl-3-phenyl-4-isoxazolyl)-N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]benzenesulfonamide
• methyl-3-phenylisoxazol-4-yl)phenyl)
• Parecoxib-006
• sulfonyl)benzenesulfonamide sodium
• Valdecoxib IMpurity L

4-(5-Methyl-3-phenylisoxazol-4-yl)-N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)benzenesulfonamide

CAS: 1373038-60-8

Fórmula: C₃₂H₂₅N₃O₆S₂

Pureza: 98%

Peso molecular: 611.6874

Ref: IN-DA009FS0

Valdecoxib Impurity 9

CAS: 1373038-60-8

Fórmula: C₃₂H₂₅N₃O₆S₂

Forma y color: White To Off-White Solid

Peso molecular: 611.69

Ref: 4Z-V-093

4-(5-Methyl-3-phenylisoxazol-4-yl)-N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)benzenesulfonamide (Palbociclib Impurity)

CAS: 1373038-60-8

4-(5-Methyl-3-phenylisoxazol-4-yl)-N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)benzenesulfonamide (Palbociclib Impurity)

Pureza: 98%

Peso molecular: 611.69g/mol

Ref: 54-OR1004980

4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)-N-((4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)PHENYL)SULFONYL)BENZENESULFONAMIDE

CAS: 1373038-60-8

Pureza: 97%

Peso molecular: 611.6900024414062

Ref: 10-F798921

Valdecoxib Dimer

Producto controlado

CAS: 1373038-60-8

Applications Valdecoxib Dimer is a dimeric impurity of the cyclooxygenase-2 inhibitor, Valdecoxib (V090000).

Fórmula: C₃₂H₂₅N₃O₆S₂

Forma y color: Neat

Peso molecular: 611.69

Ref: TR-V090020

Valdecoxib dimer

CAS: 1373038-60-8

Valdecoxib dimer is a drug product that has been custom synthesized to meet the customer's requirements. It is an analytical standard and is available in high purity. Valdecoxib dimer has been shown to be metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Valdecoxib dimer also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture. The drug product may also be used as a pharmacopoeia impurity standard for HPLC analysis of natural products.

Fórmula: C₃₂H₂₅N₃O₆S₂

Pureza: Min. 95%

Peso molecular: 611.7 g/mol

Ref: 3D-YEC03860

Valdecoxib Impurity 9

CAS: 1373038-60-8

Fórmula: C₃₂H₂₅N₃O₆S₂

Peso molecular: 611.69

Ref: ST-EA-CP-V38028