CAS 137530-41-7

(+)-2'-Desoxi-3'-tio-5-fluorocitidina

Descripción:

(+)-2'-Desoxi-3'-tio-5-fluorocitidina, con el número CAS 137530-41-7, es un análogo de nucleósido sintético que incorpora azufre y flúor en su estructura, modificando el nucleósido natural citidina. Este compuesto presenta un enlace tioéther en la posición 3′ y un átomo de flúor en la posición 5′, lo que mejora su estabilidad y altera su actividad biológica. Se estudia principalmente por sus potenciales propiedades antivirales y anticancerígenas, ya que puede interferir con la síntesis de ácidos nucleicos. La presencia del átomo de flúor puede aumentar la afinidad del compuesto por las polimerasas virales, convirtiéndolo en un candidato para aplicaciones terapéuticas contra ciertas infecciones virales. Además, la modificación tioéther puede contribuir a su resistencia a la degradación enzimática. El compuesto se caracteriza típicamente por su fórmula molecular, estereoquímica e interacciones específicas con objetivos biológicos, que son cruciales para entender su perfil farmacológico. En general, (+)-2'-Desoxi-3'-tio-5-fluorocitidina representa un área significativa de investigación en química medicinal y desarrollo de fármacos.

Fórmula: C₈H₁₀FN₃O₃S

InChI: InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m1/s1

Clave InChI: InChIKey=XQSPYNMVSIKCOC-RITPCOANSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)SC2)C=C(F)C(N)=N1

Sinónimos:

• (+)-2′-Deoxy-3′-thia-5-fluorocytidine
• (+)-Ftc
• 1,3-Oxathiolane, 2(1H)-pyrimidinone deriv.
• 1-(2-(Hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine
• 2',3',5-Ftc
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, rel-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, cis-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2S-cis)-
• 3'-Thia-2'.3'-dideoxy-5-fluorocytidine
• 4-Amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
• 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
• 4-amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
• 5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
• 524W91
• Bw 524W91
• RCV
• Racivir

Emtricitabine Enantiomer (4-amino-5-fluoro-1-((2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one; 5-Fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine)

CAS: 137530-41-7

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₈H₁₀FN₃O₃S

Forma y color: Off-White Solid

Peso molecular: 247.04269

Ref: 45-1A04620

ent-Emtricitabine

CAS: 137530-41-7

Fórmula: C₈H₁₀FN₃O₃S

Pureza: 95%

Forma y color: Solid

Peso molecular: 247.2467

Ref: IN-DA0013HH

Emtricitabine Enantiomer

CAS: 137530-41-7

Fórmula: C₈H₁₀FN₃O₃S

Forma y color: White To Off-White Solid

Peso molecular: 247.24

Ref: 4Z-E-581

(+)-Emtricitabine

CAS: 137530-41-7

Ref: 7W-GC3631

Emtricitabine IP Impurity D

CAS: 137530-41-7

Fórmula: C₈H₁₀FN₃O₃S

Peso molecular: 247.25

Ref: ST-EA-CP-E5001

ent-Emtricitabine

Producto controlado

CAS: 137530-41-7

Stability Hygroscopic
Applications A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).
References Mellors, J., et al.: Science, 72, 1167 (1996), Reimann, K., et al.: J. Virol., 79, 8878 (2005), Rose, J., et al.: J. Biol. Chem., 280, 7413 (2005), Acierno, P., et al.: J. Immunol., 176, 5338 (2006),

Fórmula: C₈H₁₀FN₃O₃S

Forma y color: Neat

Peso molecular: 247.25

Ref: TR-E525005

(+)-Emtricitabine

CAS: 137530-41-7

Emtricitabine is a synthetic nucleoside analog of cytidine. It is used in the treatment of HIV infection and hepatitis B virus infection. Emtricitabine binds to human DNA polymerase, preventing the incorporation of viral DNA into the host cell's genome. This prevents the virus from multiplying and reproducing, thereby inhibiting the spread of HIV in humans. The drug has been shown to inhibit replication at all stages of HIV-1, including reverse transcription and integration into host cell DNA. Emtricitabine also inhibits replication of other viruses such as herpes simplex virus type 1 (HSV-1) and hepatitis C virus (HCV). Emtricitabine is a prodrug that must be activated by phosphorylation before it can be incorporated into DNA. This activation requires tenofovir alafenamide hemifumarate as an activator, which is an experimental drug with improved bioavailability, reduced renal clearance, and

Fórmula: C₈H₁₀FN₃O₃S

Pureza: Min. 95%

Peso molecular: 247.25 g/mol

Ref: 3D-NE16704