CAS 137813-35-5

CICLO(ARG-GLY-ASP-D-PHE-VAL)

Descripción:

CICLO(ARG-GLY-ASP-D-PHE-VAL), con el número CAS 137813-35-5, es un péptido cíclico compuesto por cinco aminoácidos: arginina (Arg), glicina (Gly), ácido aspártico (Asp), D-fenilalanina (D-Phe) y valina (Val). La estructura cíclica se forma al enlazar los grupos amino y carboxilo terminales, lo que mejora su estabilidad en comparación con los péptidos lineales. Este compuesto exhibe características típicas de los péptidos, como la capacidad de interactuar con receptores biológicos y enzimas, lo que lo hace de interés en la investigación farmacéutica, particularmente en el diseño y desarrollo de fármacos. Su secuencia específica y naturaleza cíclica pueden contribuir a actividades biológicas únicas, incluidos roles potenciales en la modulación de procesos celulares o como andamiaje para la entrega de fármacos. Además, la presencia de aminoácidos D, como D-Phe, puede influir en la resistencia del péptido a la degradación enzimática, mejorando aún más su potencial terapéutico. En general, CICLO(ARG-GLY-ASP-D-PHE-VAL) representa un compuesto valioso en el campo de la química medicinal y la investigación de péptidos.

Fórmula: C₂₆H₃₈N₈O₇

Sinónimos:

• Cyclo(Rgdd-Fv)
• Rgdfv Peptide, Cyclic

Cyclo(-Arg-Gly-Asp-D-Phe-Val)

CAS: 137813-35-5

c(RGDfV) is a potent inhibitor of cell adhesion. It inhibited tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats provided the first evidence of its utility in the amelioration of ischemic acute renal failure. c(RGDfV) inhibited tubular obstruction by preventing cell-cell adhesion. Hammes et al. showed that the cyclopeptide can also be used to prevent retinal neovascularization. c(RGDfV) binds to αvβ3 receptors.

Fórmula: C₂₆H₃₈N₈O₇

Pureza: 96.9%

Forma y color: White Lyophilisate

Peso molecular: 574.64

Ref: 01-4026200

Cyclo(Arg-Gly-Asp-D-Phe-Val)

CAS: 137813-35-5

Cyclo(Arg-Gly-Asp-D-Phe-Val) is a peptide inhibitor of protein interactions. It binds to the ligand binding site of receptor and inhibits the activation of this receptor. Cyclo(Arg-Gly-Asp-D-Phe-Val) also binds to antibodies and can be used as a research tool for identifying antibody targets.

Fórmula: C₂₆H₃₈N₈O₇•CH₃COOH•2H₂O

Pureza: Min. 95%

Peso molecular: 670.91 g/mol

Ref: 3D-ICA-4304-V

Cyclo(Arg-Gly-Asp-D-Phe-Val)

CAS: 137813-35-5

Cyclo(Arg-Gly-Asp-D-Phe-Val) is a cyclic peptide that inhibits the activity of surface glycoprotein enzymes. It has shown to be effective against malignant brain tumor cells and has anti-angiogenic effects. Cyclo(Arg-Gly-Asp-D-Phe-Val) also inhibits integrin receptor function by binding to the αVβ3 or αVβ5 integrin, which may be useful for biomarker identification. This compound is potent as an antagonist to epidermal growth factor (EGF), which may have potential use in treating benign prostatic hyperplasia.

Fórmula: C₂₆H₃₈N₈O₇

Pureza: Min. 95%

Peso molecular: 574.63 g/mol

Ref: 3D-ICA-4304

Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt

CAS: 137813-35-5

Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt is a basic fibroblast growth factor that has been shown to have proliferative effects on diabetic retinopathy and ocular neovascularization. It binds to integrin receptors on the surface of cells, which are involved in cell adhesion. Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt also has antiangiogenic effects and blocks the angiogenesis process by inhibiting the production of epidermal growth factor (EGF). This drug may be useful for treating certain types of cancer such as malignant brain tumors or neuroblastomas, because it can cause neuronal death. Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt is a cyclic peptide with a reactive amino acid side chain.

Fórmula: C₂₆H₃₈N₈O₇

Pureza: Min. 95%

Peso molecular: 574.63 g/mol

Ref: 3D-FC108714