CAS 138-14-7
:Mesilato de deferoxamina
Descripción:
Mesilato de deferoxamina es un agente quelante que se utiliza principalmente en el tratamiento de condiciones de sobrecarga de hierro, como las que resultan de transfusiones de sangre repetidas en pacientes con condiciones como la talasemia o la enfermedad de células falciformes. Es un compuesto soluble en agua que forma complejos estables con iones férricos, facilitando su excreción del cuerpo. La sustancia se deriva de la bacteria *Streptomyces pilosus* y se caracteriza por su capacidad para unirse selectivamente al hierro, reduciendo así su toxicidad y previniendo el daño a los órganos. Mesilato de deferoxamina se administra típicamente por vías subcutáneas o intravenosas, y su farmacocinética implica una distribución rápida y excreción renal. El compuesto es conocido por su perfil de toxicidad relativamente bajo, aunque los efectos secundarios potenciales pueden incluir reacciones alérgicas, trastornos gastrointestinales y efectos en la visión con el uso prolongado. Su efectividad en el manejo de la sobrecarga de hierro lo ha convertido en un agente terapéutico crítico en entornos de hematología y oncología.
Fórmula:C25H48N6O8·CH4O3S
InChI:InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
Clave InChI:InChIKey=IDDIJAWJANBQLJ-UHFFFAOYSA-N
SMILES:S(C)(=O)(=O)O.C(CCC(NCCCCCN(C(C)=O)O)=O)(N(CCCCCNC(CCC(N(CCCCCN)O)=O)=O)O)=O
Sinónimos:- Ba 33112
- Butanediamide, N<sup>4</sup>-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N<sup>1</sup>-(5-aminopentyl)-N<sup>1</sup>-hydroxy-, methanesulfonate (1:1)
- Butanediamide, N′-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate (salt)
- DFX mesylate
- Deferoxamine B mesylate
- Deferoxamine Mesilate
- Deferoxamine methanesulfonate
- Deferrioxamine B methanesulfonate
- Deferrioxamine methanesulfonate
- Desferal
- Desferal mesylate
- Desferrioxamine B mesylate
- Desferrioxamine B methanesulfonate
- Desferrioxamine mesilate
- Desferrioxamine mesylate
- Desferrioxamine methanesulfonate
- N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:1)
- N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:2)
- NSC 644468
- Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, methanesulfonate
- Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, monomethanesulfonate (salt)
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Encontrado 14 productos.
Deferoxamine Mesylate
CAS:Fórmula:C25H48N6O8·CH4O3SPureza:>97.0%(T)(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:656.79Desferrioxamine mesilate
CAS:Desferrioxamine mesilateFórmula:C27H56N6O14S2Forma y color:Off-WhitePeso molecular:752.8953Deferoxamine Mesylate
CAS:Non-aromatic organic derivatives of hydrazine or of hydroxylamine for use as drugsFórmula:C25H48N6O8·CH4O3SForma y color:White PowderPeso molecular:656.34148Deferoxamine Mesylate
CAS:Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Fórmula:C26H52N6O11SPureza:94.68% - 99.8%Forma y color:SolidPeso molecular:656.79Deferoxamine mesylate
CAS:Deferoxamine mesylateFórmula:C25H48N6O8·CH3SO3HPureza:By hplc: 99.0% by area (Typical Value in Batch COA)Forma y color: white solidPeso molecular:656.79g/molDesferrioxamine B mesylate
CAS:Fórmula:C25H48N6O8·CH4O3SPureza:≥ 98.0%Forma y color:White to almost white powderPeso molecular:656.79Deferoxamine Mesylate
CAS:Producto controlado<p>Applications An iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients<br>References Inati, A. et al.: Am. J. Hematol., 85, 782 (2010); Selim, M.: Translat. Stroke Res., 1, 35 (2010); Cappellini, M.D. et al.: Hemoblobin, 33, 258 (2009);<br></p>Fórmula:C25H48N6O8·CH4O3SForma y color:Off-WhitePeso molecular:656.79Deferoxamine mesylate
CAS:<p>Deferoxamine is a very well known drug for the treatment of iron excess occurring in patients with thalassemia who are receiving regular transfusions. Excessive iron intake from diet may also cause accumulation of the metal ions which result in several symptoms such as metabolic acidosis and hypovolemic shock. The mechanism of action of Deferoxamine is based on its ability to chelate iron and other metal ions (i.e. aluminum) permitting their rapid urinary elimination. Recently, another potential therapeutic uses of Deferoxamine for treating diabetic neuropathy was suggested since it was observed that the drug could activate the production of pro-angiogenic, neuroprotective and anti inflammatory factors. Read the full story here: <a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178011" target="_blank" rel="noreferrer noopener">http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178011</a></p>Fórmula:C26H52N6O11SPureza:Min. 98.0 Area-%Peso molecular:656.79 g/molRef: 3D-D-0675
5gA consultar10gA consultar25gA consultar50gA consultar100gA consultar-Unit-ggA consultarDeferoxamine mesylate
CAS:<p>Deferoxamine mesylate is an iron chelator that is used in the treatment of iron overload and to treat patients with chronic renal failure. Deferoxamine mesylate has been shown to inhibit angiogenesis by inhibiting the basic protein required for this process. It is also known to have a protective effect on myocardial cells, preventing cell death due to lack of oxygen (reactive oxygen species). Deferoxamine mesylate also inhibits neuronal death in a model system.<br>Deferoxamine mesylate binds to DNA and inhibits RNA synthesis, which has led to its use as a fluorescence probe for the detection of DNA binding activity. The drug has also been shown to act as a metal chelate, binding with metals such as iron, copper, and zinc.</p>Fórmula:C26H52N6O11SPureza:Min. 95 Area-%Forma y color:PowderPeso molecular:656.79 g/mol
