CAS 138068-37-8

Lepirudina

Descripción:

Lepirudina es un anticoagulante sintético derivado de la saliva de la sanguijuela medicinal, Hirudo medicinalis. Funciona como un inhibidor directo de la trombina, lo que significa que se une a la trombina y evita que convierta el fibrinógeno en fibrina, inhibiendo así la formación de coágulos sanguíneos. Lepirudina se utiliza principalmente en entornos clínicos para el tratamiento de pacientes con trombocitopenia inducida por heparina (HIT), una condición en la que la terapia con heparina conduce a una disminución en el recuento de plaquetas y un aumento del riesgo de trombosis. La sustancia se caracteriza por su alta especificidad por la trombina, lo que la hace efectiva en el manejo de trastornos trombóticos. Lepirudina se administra por inyección intravenosa, y su farmacocinética incluye una vida media relativamente corta, lo que requiere un monitoreo cuidadoso de los niveles de anticoagulación en los pacientes. Los efectos adversos pueden incluir complicaciones hemorrágicas, que son comunes con los anticoagulantes, y reacciones de hipersensibilidad. En general, Lepirudina representa una opción terapéutica crítica en el manejo de la anticoagulación, particularmente para pacientes con contraindicaciones a anticoagulantes tradicionales como la heparina.

Fórmula: C₂₈₇H₄₄₀N₈₀O₁₁₁S₆

InChI: InChI=1/C287H446N80O111S6/c1-24-132(17)225(359-272(462)187(122-483)350-242(432)147(41-30-33-81-289)322-258(448)170(95-197(297)384)317-206(393)108-303-233(423)148(54-67-192(292)379)313-202(389)107-310-240(430)183(118-479)355-278(468)223(130(13)14)357-265(455)174(99-201(301)388)342-266(456)180(115-369)319-208(395)110-304-235(425)150(60-73-212(400)401)323-269(459)184(119-480)352-254(444)165(90-129(11)12)335-270(460)185(120-481)353-253(443)164(89-128(9)10)334-260(450)172(97-199(299)386)340-244(434)151(55-68-193(293)380)315-204(391)106-309-239(429)179(114-368)348-249(439)158(65-78-217(410)411)330-281(471)229(136(21)374)363-273(463)188(123-484)354-263(453)178(103-222(420)421)347-283(473)230(137(22)375)362-264(454)168(93-141-48-52-144(378)53-49-141)346-282(472)228(135(20)373)361-232(422)145(291)86-125(3)4)280(470)345-162(87-126(5)6)236(426)306-111-209(396)320-181(116-370)267(457)344-176(101-220(416)417)238(428)307-105-203(390)316-152(61-74-213(402)403)243(433)321-146(40-29-32-80-288)241(431)339-171(96-198(298)385)259(449)326-153(56-69-194(294)381)250(440)351-186(121-482)271(461)358-224(131(15)16)279(469)364-227(134(19)372)277(467)311-112-205(392)314-149(59-72-211(398)399)234(424)305-113-210(397)356-231(138(23)376)286(476)367-85-37-45-191(367)276(466)331-160(42-31-34-82-290)284(474)365-83-35-43-189(365)274(464)328-154(57-70-195(295)382)248(438)349-182(117-371)268(458)338-169(94-142-104-302-124-312-142)257(447)341-173(98-200(300)387)261(451)343-175(100-219(414)415)237(427)308-109-207(394)318-177(102-221(418)419)262(452)337-166(91-139-38-27-26-28-39-139)255(445)327-155(62-75-214(404)405)245(435)325-159(66-79-218(412)413)251(441)360-226(133(18)25-2)285(475)366-84-36-44-190(366)275(465)329-157(64-77-216(408)409)246(436)324-156(63-76-215(406)407)247(437)336-167(92-140-46-50-143(377)51-47-140)256(446)333-163(88-127(7)8)252(442)332-161(287(477)478)58-71-196(296)383/h26-28,38-39,46-53,104,124-138,145-191,223-231,368-378,479-484H,24-25,29-37,40-45,54-103,105-123,288-291H2,1-23H3,(H2,292,379)(H2,293,380)(H2,294,381)(H2,295,382)(H2,296,383)(H2,297,384)(H2,298,385)(H2,299,386)(H2,300,387)(H2,301,388)(H,302,312)(H,303,423)(H,304,425)(H,305,424)(H,306,426)(H,307,428)(H,308,427)(H,309,429)(H,310,430)(H,311,467)(H,313,389)(H,314,392)(H,315,391)(H,316,390)(H,317,393)(H,318,394)(H,319,395)(H,320,396)(H,321,433)(H,322,448)(H,323,459)(H,324,436)(H,325,435)(H,326,449)(H,327,445)(H,328,464)(H,329,465)(H,330,471)(H,331,466)(H,332,442)(H,333,446)(H,334,450)(H,335,460)(H,336,437)(H,337,452)(H,338,458)(H,339,431)(H,340,434)(H,341,447)(H,342,456)(H,343,451)(H,344,457)(H,345,470)(H,346,472)(H,347,473)(H,348,439)(H,349,438)(H,350,432)(H,351,440)(H,352,444)(H,353,443)(H,354,453)(H,355,468)(H,356,397)(H,357,455)(H,358,461)(H,359,462)(H,360,441)(H,361,422)(H,362,454)(H,363,463)(H,364,469)(H,398,399)(H,400,401)(H,402,403)(H,404,405)(H,406,407)(H,408,409)(H,410,411)(H,412,413)(H,414,415)(H,416,417)(H,418,419)(H,420,421)(H,477,478)/t132-,133-,134+,135+,136+,137+,138+,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,187-,188-,189-,190-,191-,223-,224-,225-,226-,227-,228-,229-,230-,231-/m0/s1

Sinónimos:

• Lepirudin Recombinant

Lepirudin

CAS: 138068-37-8

Synthetic peptide. Lepirudin is an anticoagulant which functions as a direct thrombin inhibitor.

Fórmula: C₂₈₇H₄₄₀N₈₀O₁₁₁S₆

Pureza: 95.2%

Forma y color: White Lyophilisate

Peso molecular: 6979.52

Ref: 01-4048773

Lepirudin acetate salt

CAS: 138068-37-8

Lepirudin acetate salt is a recombinant heparin that inhibits the activity of thrombin, an enzyme that converts fibrinogen to fibrin. Lepirudin acetate salt binds to thrombin and prevents it from binding to its target sites on the fibrinogen molecule. It is used as an anticoagulant in patients with heparin-induced thrombocytopenia. Lepirudin acetate salt has been shown to be effective against hirudin and lepirudin, which are inhibitors of heparins. The drug also inhibits the formation of polymerase chain reaction products by human polymorphonuclear leukocytes in vitro.

Fórmula: C₂₈₇H₄₄₀N₈₀O₁₁₁S₆

Pureza: Min. 95%

Peso molecular: 6,979.43 g/mol

Ref: 3D-FL109904

Lepirudin

CAS: 138068-37-8

Lepirudin is a drug used to treat thrombosis and pulmonary embolism. It inhibits the function of thrombin by binding to its active site and preventing it from converting fibrinogen into fibrin. Lepirudin is an inhibitor molecule that binds to human polymorphonuclear leukocytes, which are cells that contain large quantities of protein. The rate constant for the reaction between these two molecules was determined using chromatographic analysis. Lepirudin has been shown to be toxic in animal studies, leading to allergic symptoms such as rash, fever, chills, nausea, and vomiting. These reactions were reduced when given orally as a prodrug.

Fórmula: C₂₈₇H₄₄₀N₈₀O₁₁₁S₆

Pureza: Min. 95%

Peso molecular: 6,979.43 g/mol

Ref: 3D-FL168419