CAS 1393-48-2

Tiostrepton

Descripción:

Tiostrepton es un antibiótico tiopéptido que ocurre de forma natural, producido principalmente por la bacteria *Streptomyces azureus*. Se caracteriza por su estructura compleja, que incluye un núcleo bicíclico único y múltiples grupos que contienen azufre, lo que contribuye a su actividad biológica. Tiostrepton exhibe potentes propiedades antimicrobianas, particularmente contra bacterias Gram-positivas, y se ha estudiado por sus posibles aplicaciones en el tratamiento de diversas infecciones. El compuesto funciona inhibiendo la síntesis de proteínas, dirigiéndose específicamente al ARN ribosómico, lo que interrumpe el proceso de traducción en las células bacterianas. Además de sus efectos antibacterianos, Tiostrepton ha mostrado promesas en la investigación del cáncer debido a su capacidad para interferir con las vías de señalización celular. Se administra típicamente en un entorno de laboratorio, y su uso está restringido principalmente a fines de investigación. Se requieren precauciones de seguridad al manejar Tiostrepton, como con muchos antibióticos, para prevenir el desarrollo de resistencia y asegurar resultados terapéuticos efectivos. En general, Tiostrepton representa un compuesto significativo en el campo de la microbiología y la química medicinal.

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

InChI: InChI=1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,97)(H,75,99)(H,76,98)(H,77,101)(H,78,105)(H,82,106)(H,88,103)(H,89,102)(H,90,104)(H,91,100)/b38-15-/t26-,30-,31-,32-,33+,34+,35+,39+,45+,47-,48-,49-,51-,52+,53+,71+,72+/m0/s1

Clave InChI: InChIKey=NSFFHOGKXHRQEW-AIHSUZKVSA-N

SMILES: O=C1N[C@]23[C@@](C=4N=C(SC4)[C@@](NC(=O)C=5N=C(SC5)[C@]([C@]([C@@H](C)O)(C)O)(NC(=O)[C@@]6(N=C(\C(=C\C)\NC(=O)[C@]([C@@H](C)O)(NC(=O)C=7N=C2SC7)[H])SC6)[H])[H])([C@@H](C)OC(=O)C=8N=C9C(=C([C@H](C)O)C8)C=C[C@]([C@@H]9O)(N[C@@]([C@H](CC)C)(C(=O)N[C@@H](C)C(=O)NC(=C)C(=O)N[C@H]1C)[H])[H])[H])(N=C(CC3)C%10=NC(C(NC(C(NC(C(N)=O)=C)=O)=C)=O)=CS%10)[H]

Sinónimos:

• Alaninamide, <span class="text-smallcaps">L</smallcap>-threonyl-(4S)-2-[(1Z)-1-amino-1-propenyl]-4,5-dihydro-4-thiazolecarbonyl-2-[(1S,2S,3R)-1-amino-2,3-dihydroxy-2-methylbutyl]-4-thiazolecarbonyl-2-[(5R,6S)-6-[2-[(1S,2R)-1-amino-2-hydroxypropyl]-4-thiazolyl]-5-[[N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-<smallcap>L</smallcap>-isoleucyl-<smallcap>L</smallcap>-alanyl-2,3-didehydroalanyl-<smallcap>L</span>-alanyl]amino]-5-(4-carboxy-2-thiazolyl)-3,4,5,6-tetrahydro-2-pyridinyl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (1′→4)-lactone, (4→1)-lactam
• Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-<span class="text-smallcaps">L</smallcap>-isoleucyl-<smallcap>L</smallcap>-alanyl-2,3-didehydroalanyl-<smallcap>L</span>-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (1→5²⁸)-lactone
• Bryamycin
• Gargon
• N-{3-[(3-amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl}-2-[(11E)-37-(butan-2-yl)-18-(2,3-dihydroxybutan-2-yl)-11-ethylidene-59-hydroxy-8,31-bis(1-hydroxyethyl)-26,40,46-trimethyl-43-methylidene-6,9,16,23,28,38,41,44,47-nonaoxo-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecaazanonacyclo[23.23.9.3~29,35~.1~2,5~.1~12,15~.1~19,22~.1~54,57~.0~1,53~.0~32,60~]tetrahexaconta-2(64),4,12(63),19(62),21,29,31,33,51,54,57,60-dodecaen-51-yl]-1,3-thiazole-4-carboxamide (non-preferred name)
• NSC 170365
• NSC 81722
• Thiactin
• Thiostrepton
• Thiostrepton A
• Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (1→528)-lactone

Thiostrepton, Streptomyces laurentii, 90+%

CAS: 1393-48-2

Natural cyclic oligopeptide antibiotic

Fórmula: C₇₂H₈₅O₁₈N₁₉S₅

Pureza: 90+%

Forma y color: Powder

Peso molecular: 1664.89

Ref: 02-J62332

Thiostrepton

CAS: 1393-48-2

Antibiotics nesoi

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

Forma y color: White Powder

Peso molecular: 1663.49235

Ref: 45-1663700

Thiostrepton

CAS: 1393-48-2

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

Pureza: 98%

Forma y color: Solid

Peso molecular: 1664.8868

Ref: IN-DA006XMY

Thiostrepton from Streptomyces azureus

CAS: 1393-48-2

Thiostrepton from Streptomyces azureus

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

Pureza: By hplc: 98.42% (Typical Value in Batch COA)

Forma y color: white powder

Peso molecular: 1,664.89g/mol

Ref: 54-BIT1003

Thiostrepton

CAS: 1393-48-2

Fórmula: C₇₂H₈₅O₁₈N₁₉S₅

Pureza: ≥ 98.0%

Forma y color: White to pale yellow powder

Peso molecular: 1664.89

Ref: 7W-GA3924

Thiostrepton

CAS: 1393-48-2

Thiostrepton is a cyclic peptide from Streptomyces, active against gram-positive bacteria, used in veterinary medicine for mastitis and skin issues.

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

Pureza: 98.09% - 99.57%

Forma y color: Solid

Peso molecular: 1664.89

Ref: TM-T1679

Thiostrepton

Producto controlado

CAS: 1393-48-2

Stability Hygroscopic
Applications Natural antibiotic derived from Streptomyces.
References Starosta, A., et al.; Chem. Biol., 16, 1087 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Kwok, J., et al.: Mol. Cancer Res., 8, 24 (2010),

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

Forma y color: Neat

Peso molecular: 1664.89

Ref: TR-T375150

Thiostrepton

CAS: 1393-48-2

Thiostrepton is a thiopeptide antibiotic with action on bacterial protein synthesis by binding to the ribosome and is used for treating bacterial infections in veterinary medicine and research applications.

Fórmula: C₇₂H₈₅N₁₉O₁₈S₅

Pureza: Min. 95%

Forma y color: White To Light (Or Pale) Yellow Solid

Peso molecular: 1,664.89 g/mol

Ref: 3D-FT28240