CAS 139481-72-4

Trityl Candesartán

Descripción:

Trityl Candesartán, con el número CAS 139481-72-4, es un compuesto químico que pertenece a la clase de antagonistas del receptor de angiotensina II, diseñado específicamente para el tratamiento de la hipertensión y la insuficiencia cardíaca. Es un profármaco de Candesartán, lo que significa que se convierte en su forma activa en el cuerpo. La estructura de Trityl Candesartán presenta un grupo tritilo, que mejora su lipofilia y biodisponibilidad. Este compuesto exhibe alta afinidad por el receptor de angiotensina II, lo que conduce a la vasodilatación y una posterior reducción de la presión arterial. Su perfil farmacocinético incluye buena absorción y una vida media relativamente larga, lo que permite una dosificación una vez al día. Además, Trityl Candesartán se caracteriza por su estabilidad en condiciones fisiológicas, lo que lo hace adecuado para aplicaciones terapéuticas. Al igual que con muchos fármacos, es esencial considerar los posibles efectos secundarios y contraindicaciones, que pueden incluir mareos, hipotensión y deterioro renal. En general, Trityl Candesartán representa un avance significativo en la terapia antihipertensiva.

Fórmula: C₄₃H₃₄N₆O₃

InChI: InChI=1/C43H34N6O3/c1-2-52-42-44-38-24-14-23-37(41(50)51)39(38)48(42)29-30-25-27-31(28-26-30)35-21-12-13-22-36(35)40-45-46-47-49(40)43(32-15-6-3-7-16-32,33-17-8-4-9-18-33)34-19-10-5-11-20-34/h3-28H,2,29H2,1H3,(H,50,51)

Clave InChI: InChIKey=VBMKOTRJWPIKMG-UHFFFAOYSA-N

SMILES: C(N1C(=NN=N1)C2=C(C=CC=C2)C3=CC=C(CN4C=5C(N=C4OCC)=CC=CC5C(O)=O)C=C3)(C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8

Sinónimos:

• 1H-benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-
• 2-Ethoxy-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid
• 2-Ethoxy-1-[(2′-(1-trityl-1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl)methyl]-7-benzimidazolecarboxylic acid
• 2-Ethoxy-1-[[2′-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
• 2-Ethoxy-1-{[2'-(1-trityl-1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylic acid
• 2-Ethoxy-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid
• 2-ethoxy-1-[[(2'-(1-triphenylmethyl-1h-tetrazol-5-yl)biphenyl-4-yl)methyl]benzimidazole-7-carboxylic acid
• DISCONTINUED
• TritylCandesartan[CandesartabCilexetilIntermediates]
• Candesartan Cilexetil Impurity 9
• 2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-c
• 2-ETHOXY-1-[[(2-(1-TRIPHENYLMETHYL-1H-TETRAZOL-5-YL)BIPHENYL)METHYL] BENZIMIDAZOLE-7-CARBOXYLIC ACID
• 2-ethoxy-3-[[4-[2-[1-(triphenylmethyl)-5-tetrazolyl]phenyl]phenyl]methyl]-4-benzimidazolecarboxylic acid
• (Trityl candesartan)2-Ethoxy-1-[[2-(2-Triphenyl Methyl)-2H-Tetrazole-5-YL](1,1-Biphenyl)-4-YL]Methyl]Benzimidazole-2-Carboxylic Acid
• Triphenyl Candesartan
• Candesartan N1-Trityl IMpurity
• (1H)-Benzimidazole-7-carboxylicacid
• 2-Ethoxy-1-[[(2’-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-yl-)methyl]benzimidazole-7-carboxylicacid
• Trityl candesartan/2-Ethoxy-1-[[(2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl]benzimidazole-7-carboxylic acid
• Candesartan Impurity 8
• TRITYL CANDESARTAN
• TRITYL CANDESARTAN ( FOR CANDESARTAN CILEXETIL )
• Trityl candesartan USP/EP/BP
• Yl][1,1?-Biphenyl]-4-Yl]Methyl]-1H-Benzimidazole-7- Carboxylic Acid [N-Trityl Candesartan]
• N-Trityl Candesartan
• 2-Ethoxy-1-[[2?-[2-(Triphenylmethyl)-2H-Tetrazol-5-
• 2-ethoxy-1-[[(2-(1-triphenylmethyl-1Htetrazol-5-yl)biphenyl-4-yl-)
• CANDESARTAN INTERMEDIATE A
• Intermediate 5
• 2-Ethoxy-1-[[2-(2-Triphenylmethyl)-2H-Tetrazole-5-Yl](1,1-Biphenyl)-4-Yl]-Methyl]Benzimidazole-7-Carboylicacid
• Candesartan Cilexetil
• N-trimethylcandesartan
• Candesartan Cilexetil Impurity 14
• Trityl Candesartan (C9)
• 2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-
• TritylCandesartan,CandesartanCilexetil

Trityl candesartan

CAS: 139481-72-4

Fórmula: C₄₃H₃₄N₆O₃

Pureza: 97%

Forma y color: Solid

Peso molecular: 682.7685

Ref: IN-DA007Z8Q

2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid

CAS: 139481-72-4

2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid

Pureza: 97%

Peso molecular: 682.78g/mol

Ref: 54-OR1068771

N-Trityl Candesartan

CAS: 139481-72-4

Fórmula: C₄₃H₃₄N₆O₃

Forma y color: White To Off-White Solid

Peso molecular: 682.79

Ref: 4Z-C-0113

Trityl candesartan

CAS: 139481-72-4

Trityl candesartan is a crucial intermediate used in the synthesis of Candesartan and Candesartan cilexetil, which are angiotensin II receptor antagonists.

Fórmula: C₄₃H₃₄N₆O₃

Pureza: 98.97%

Forma y color: Solid

Peso molecular: 682.77

Ref: TM-T65740

N-Trityl Candesartan

CAS: 139481-72-4

Fórmula: C₄₃H₃₄N₆O₃

Peso molecular: 682.77

Ref: ST-EA-CP-C50018

N-Trityl candesartan

CAS: 139481-72-4

N-Trityl candesartan is a benzimidazole derivative. It is a prodrug that is activated by esterases to the active form, candesartan. Candesartan has been shown to be effective in the treatment of high blood pressure when combined with cilexetil, but not when used alone. The regression analysis data showed that N-trityl candesartan was more potent than candesartan in lowering blood pressure in rats. This analog also had improved uptake and metabolism compared to its parent compound.

Fórmula: C₄₃H₃₄N₆O₃

Pureza: Min. 95%

Peso molecular: 682.77 g/mol

Ref: 3D-FT28595