CAS 142439-99-4

4-metilumbeliferil-7-(6-sulfo-2-*acetamido-2-de

Descripción:

4-Metilumbeliferilo-7-(6-sulfo-2-acetamido-2-desoxi-α-D-glucopiranósido), comúnmente referido como un sustrato fluorogénico, es un compuesto químico utilizado principalmente en ensayos bioquímicos, particularmente para la detección de enzimas específicas. Este compuesto presenta un grupo metilumbeliferilo, conocido por sus propiedades fluorescentes, lo que permite una detección sensible cuando es escindido por enzimas como las glicosidasas. La presencia de un grupo sulfonato mejora su solubilidad en soluciones acuosas, haciéndolo adecuado para diversas aplicaciones biológicas. Además, el grupo acetamido contribuye a la estabilidad y especificidad del sustrato. El compuesto se utiliza típicamente en entornos de investigación para estudiar la cinética y actividad enzimática, proporcionando una herramienta valiosa para entender el metabolismo de carbohidratos y las vías bioquímicas relacionadas. Su naturaleza fluorescente permite el monitoreo en tiempo real de las reacciones enzimáticas, convirtiéndolo en un reactivo esencial en biología molecular y bioquímica. Es necesario un manejo y condiciones de almacenamiento adecuados para mantener su integridad y efectividad en aplicaciones experimentales.

Fórmula: C₁₈H₂₀NNaO₁₁S

InChI: InChI=1/C18H21NO11S.Na/c1-8-5-14(21)29-12-6-10(3-4-11(8)12)28-18-15(19-9(2)20)17(23)16(22)13(30-18)7-27-31(24,25)26;/h3-6,13,15-18,22-23H,7H2,1-2H3,(H,19,20)(H,24,25,26);/q;+1/p-1/t13-,15-,16-,17-,18-;/m1./s1

SMILES: Cc1cc(=O)oc2cc(ccc12)OC1C(C(C(C(COS(=O)(=O)O)O1)O)O)N=C(C)O.[Na]

Sinónimos:

• sodium [(2R,3S,4R,5R,6S)-5-acetamido-3,4-dihydroxy-6-(4-methyl-2-oxo-chromen-7-yl)oxy-tetrahydropyran-2-yl]methyl sulfate

4-Methylumbelliferyl 2-acetamido-2-deoxy-b-D-glucopyranoside 6-sulphate sodium salt

CAS: 142439-99-4

Fórmula: C₁₈H₂₀NNaO₁₁S

Peso molecular: 481.40

Ref: 7W-GC5948

4-Methylumbelliferyl-2-acetamido-2-deoxy-6-sulphate-β-D-glucopyranoside sodium salt

CAS: 142439-99-4

4-Methylumbelliferyl-2-acetamido-2-deoxy-6-sulphate-β-D-glucopyranoside sodium salt

Fórmula: C₁₈H₂₀NO₁₁S·Na

Pureza: 99% (by tlc) (Typical Value in Batch COA)

Forma y color: off white powder

Peso molecular: 481.41g/mol

Ref: 54-BIM1189

4-Methylumbelliferyl-N-acetyl-β-D-glucosaminide-6-sulfate, sodium salt

CAS: 142439-99-4

4-Methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate sodium salt is a high-quality fluorogenic substrate specifically designed for the detection and quantification of various enzymes, including beta-glucosidases and sulfatases. Upon hydrolysis by the target enzyme, this substrate releases the highly fluorescent 4-methylumbelliferone, allowing for real-time monitoring and accurate measurement of enzyme activities in biochemical assays, diagnostic tests, and research applications. 4-Methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate sodium salt has excellent solubility in water, ensuring a consistent and reliable performance in different experimental conditions. This versatile substrate is an essential tool for researchers and industry professionals who require a sensitive and reproducible detection method for enzymes of interest.

Fórmula: C₁₈H₂₀NNaO₁₁S

Pureza: Min. 98.0 Area-%

Peso molecular: 481.41 g/mol

Ref: 3D-M-5505

4-Methylumbelliferyl 2-acetamido-2-deoxy-b-D-glucopyranoside-6-sulfate sodium salt

CAS: 142439-99-4

4-Methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate sodium salt is a high-quality fluorogenic substrate specifically designed for the detection and quantification of various enzymes, including beta-glucosidases and sulfatases. Upon hydrolysis by the target enzyme, this substrate releases the highly fluorescent 4-methylumbelliferone, allowing for real-time monitoring and accurate measurement of enzyme activities in biochemical assays, diagnostic tests, and research applications. 4-Methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate sodium salt has excellent solubility in water, ensuring a consistent and reliable performance in different experimental conditions. This versatile substrate is an essential tool for researchers and industry professionals who require a sensitive and reproducible detection method for enzymes of interest.

Fórmula: C₁₈H₂₀NO₁₁SNa

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 481.41 g/mol

Ref: 3D-EM03271

4-Methylumbelliferyl 2-Acetamido-2-deoxy-b-D-glucopyranoside 6-Sulphate Sodium Salt

Producto controlado

CAS: 142439-99-4

Applications 4-Methylumbelliferyl 2-acetamido-2-deoxy-b-D-glucopyranoside 6-sulphate sodium salt is a fluorescent substrate for isoenzyme A of N-acetyl-β-D-glucosaminidase (Hexosaminidase A). It can also be used in biological study of characterization of the mutant β-subunit of β-hexosaminidase for dimer formation responsible for the adult form of Sandhoff disease with the motor neuron disease phenotype.
References Yamada, K., et al.: J Biochem, 153, 111 (2013)

Fórmula: C₁₈H₂₁NO₁₁S·Na

Forma y color: Neat

Peso molecular: 482.41

Ref: TR-M337660