CAS 1426214-51-8

N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichlorobenzenesulfonamide

CAS: 1426214-51-8

N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichlorobenzenesulfonamide (NSC 75968) is a cytosolic calcium channel blocker. It has been shown to cause significant cytotoxicity in human cancer cells and experimental models. NSC 75968 inhibits the activity of the voltage gated L type calcium channels in tumor cells, leading to a reduction in cellular energy metabolism and a decrease in ion flux through the cell membrane. This agent has also been shown to inhibit receptor activity by binding to an allosteric site on the alpha subunit of the G protein coupled receptor.

Fórmula: C₁₇H₁₂Cl₂N₆O₂S

Pureza: Min. 95%

Peso molecular: 435.3 g/mol

Ref: 3D-BHC21451

SGK1 inhibitor

CAS: 1426214-51-8

SGK1 inhibitor targets SGK1/2 over SGK3, blocks GSK3β phosphorylation, lowers HCC1954 cell viability with BYL719, and reduces tumor growth in mice.

Fórmula: C₁₇H₁₂Cl₂N₆O₂S

Forma y color: Solid

Peso molecular: 435.29

Ref: TM-T71947