CAS 1429173-57-8

AP39 Free base

CAS: 1429173-57-8

AP39 free base is a mitochondrial targeted H(2)S donor that inhibits pyroptosis.

Fórmula: C₃₇H₃₈O₂PS₃

Pureza: 98.34%

Forma y color: Solid

Peso molecular: 641.87

Ref: TM-T35860

AP39 Free base

CAS: 1429173-57-8

AP39 Free base

Pureza: ≥95%

Peso molecular: 641.87g/mol

Ref: 54-BUP00543

AP39

Producto controlado

CAS: 1429173-57-8

Applications AP39 is a compound used to increase the level of hydrogen sulphide within the mitochondria because of the presence of the mitochondria targeting motif (triphenylphosphonium). Also used as a photosensitizer, hydrogen sulfide donor, thioredoxin inhibitor or nitroxide combination use in photodynamic therapy.
References Szczesny, B., et al.: Nitric Oxide : Biology and Chemistry, 41, 120 (2014); Wood, M. E., et al.: PCT Int. Appl. (2015), WO 2015185918 A1 20151210

Fórmula: C₃₇H₃₈O₂PS₃·Br

Forma y color: Neat

Peso molecular: 721.769

Ref: TR-A729260

AP39

CAS: 1429173-57-8

AP39 is a potent small molecule that acts as a mitochondrially-targeted hydrogen sulfide (H2S) donor exhibiting promising anticancer properties. Beyond its antitumor activity, AP39 demonstrates remarkable protective effects in renal oxidative injury and cardiomyopathy. The mechanism of action of AP39 appears to improve mitochondrial function, attenuate inflammation, and regulate mitophagy via the AMPK-ULK1-FUNDC1 pathway. Notably, AP39 prevents gastric mucosal damage and enhances cardiac function in doxorubicin-induced cardiotoxicity models. These pleiotropic effects makes AP39 to be a potential therapeutic candidate with broad applicability,  and it could bring further studies for preclinical and clinical research.

Fórmula: C₃₇H₃₈O₂PS₃

Pureza: Min. 95%

Peso molecular: 641.9 g/mol

Ref: 3D-EHC17357