CAS 143313-51-3

AC-YVAD-CHO

Descripción:

AC-YVAD-CHO es un péptido sintético que actúa como un inhibidor selectivo de la caspasa-1, una enzima involucrada en la respuesta inflamatoria y la apoptosis. Este compuesto se caracteriza por su capacidad para bloquear la activación de la caspasa-1, modulando así procesos relacionados con la inflamación y la muerte celular. La estructura de AC-YVAD-CHO incluye un grupo acetilo, que mejora su permeabilidad celular, y un grupo carbonilo que es crucial para su actividad inhibitoria. Se utiliza comúnmente en entornos de investigación para estudiar el papel de la caspasa-1 en varios procesos biológicos, incluida la maduración de citoquinas y la piroptosis. El compuesto se utiliza típicamente en experimentos in vitro y tiene implicaciones potenciales en estrategias terapéuticas para enfermedades caracterizadas por una inflamación excesiva. Al igual que muchos péptidos, su estabilidad y solubilidad pueden verse influenciadas por factores ambientales, y es esencial manejarlo bajo condiciones de laboratorio apropiadas para mantener su integridad y eficacia.

Fórmula: C₂₃H₃₂N₄O₈

InChI: InChI=1/C23H32N4O8/c1-12(2)20(23(35)27-21(33)13(3)24-16(11-28)10-19(31)32)26-22(34)18(25-14(4)29)9-15-5-7-17(30)8-6-15/h5-8,11-13,16,18,20,24,30H,9-10H2,1-4H3,(H,25,29)(H,26,34)(H,31,32)(H,27,33,35)/t13-,16-,18-,20-/m0/s1

SMILES: CC(C)[C@@H](C(=O)N=C([C@H](C)N[C@@H](CC(=O)O)C=O)O)N=C([C@H](Cc1ccc(cc1)O)N=C(C)O)O

Sinónimos:

• N-Acetyl-L-Tyrosyl-L-Valyl-N-[(1S)-2-Carboxyl-1-Formylethyl]-L-Alaninamide
• N-Acetyl-Tyr-Val-Ala-Asp-Cho (Aldehyde)
• N-Acetyl-Tyr-Val-Ala-Glu-Al
• N-Ac-Tyr-Val-Ala-Asp-Cho
• N-Acetyl-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-Cho (Aldehyde)
• Tyr-Val-Ala-Asp-Cho
• Yvad-Cho
• Ice Inhibitor
• N-acetyl-L-tyrosyl-N-[(2S)-2-{[(1S)-2-carboxy-1-formylethyl]amino}propanoyl]-L-valinamide

Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)

CAS: 143313-51-3

Ac-YVAD-CHO is a potent, specific, reversible inhibitor of caspase-1 (ICE). It displayed a Ki of 0.2 ± 0.1 nM for recombinant human caspase-1.

Fórmula: C₂₃H₃₂N₄O₈

Pureza: > 95%

Forma y color: White

Peso molecular: 492.53

Ref: 01-4018830

Caspase-1 Inhibitor I

CAS: 143313-51-3

Fórmula: C₂₃H₃₂N₄O₈

Pureza: 98%

Forma y color: Solid

Peso molecular: 492.5222

Ref: IN-DA007YY8

Ac-YVAD-CHO

CAS: 143313-51-3

Ac-YVAD-CHO

Pureza: ≥95%

Peso molecular: 492.52g/mol

Ref: 54-BUP00600

Ac-YVAD-CHO

CAS: 143313-51-3

Ac-YVAD-CHO (L 709049) is an ICE and caspase-1-like protease inhibitor with anti-inflammatory activity that inhibits the production of mature IL-lβ.

Fórmula: C₂₃H₃₂N₄O₈

Pureza: 96.49%

Forma y color: Solid

Peso molecular: 492.52

Ref: TM-T19883

Ac-Tyr-Val-Ala-Asp-H (aldehyde)

CAS: 143313-51-3

Ac-Tyr-Val-Ala-Asp-H (aldehyde) is a peptide that inhibits the activity of protein tyrosine phosphatases, which are enzymes that remove phosphate groups from proteins. This agent binds to the amino acid side chains of an enzyme and prevents it from binding to its substrate. Ac-Tyr-Val-Ala-Asp-H (aldehyde) is a research tool that can be used in life sciences as an inhibitor or activator for peptides, receptors, and ion channels. Ac-Tyr-Val-Ala-Asp-H (aldehyde) has been shown to be active in the inhibition of protein tyrosine phosphatase 1B and 2A isoforms.

Fórmula: C₂₃H₃₂N₄O₈

Pureza: Min. 95%

Peso molecular: 492.52 g/mol

Ref: 3D-IAT-3165-V

Caspase-1 Inhibitor I

Producto controlado

CAS: 143313-51-3

Fórmula: C₂₃H₃₂N₄O₈

Forma y color: Neat

Peso molecular: 492.522

Ref: TR-C184910

Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)

CAS: 143313-51-3

Ac-Tyr-Val-Ala-Asp-aldehyde is a sesquiterpene lactone that has been shown to have anti-inflammatory properties. It inhibits the inflammatory response by inhibiting the production of pro-inflammatory cytokines and chemokines, such as IL1β, IL6, and TNFα. Ac-Tyr-Val-Ala-Asp-aldehyde also inhibits the activity of cyclooxygenase 2 (COX2) and lipoxygenase (LOX), which are enzymes that produce prostaglandins from arachidonic acid. Acetylsalicylic acid is an example of a drug with similar properties. Acetylsalicylic acid has been shown to inhibit the growth of cancer cells in tissue culture studies and in animal models. This compound may also be used to treat bowel disease, congestive heart failure, or other diseases that are characterized by increased apoptosis.

Fórmula: C₂₃H₃₂N₄O₈

Pureza: Min. 95%

Peso molecular: 492.52 g/mol

Ref: 3D-FA110311