CAS 1445-07-4

Pseudouridina

Descripción:

Pseudouridina es un nucleósido que ocurre de forma natural y es un derivado de la uridina, distinguido por la presencia de un enlace carbono-carbono entre el azúcar ribosa y la base de uracilo, en lugar del típico enlace nitrógeno-carbono que se encuentra en los nucleósidos estándar. Esta modificación mejora la estabilidad de las moléculas de ARN y se piensa que juega un papel en la regulación de la expresión génica y la estructura del tRNA. Pseudouridina se encuentra comúnmente en varias especies de ARN, incluyendo tRNA y rRNA, y está involucrado en varios procesos biológicos. Su fórmula química es C10H13N2O5, y tiene un peso molecular de aproximadamente 225.23 g/mol. Pseudouridina exhibe propiedades únicas como una mayor estabilidad térmica y resistencia a la degradación enzimática, lo que lo convierte en una molécula importante en el estudio de la biología del ARN y aplicaciones terapéuticas potenciales. Además, se ha investigado su papel en la modificación del ARN en varios organismos, contribuyendo a la comprensión de la función y evolución del ARN.

Fórmula: C₉H₁₂N₂O₆

InChI: InChI=1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1

Clave InChI: InChIKey=PTJWIQPHWPFNBW-GBNDHIKLSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C=2C(=O)NC(=O)NC2

Sinónimos:

• (1S)-1,4-anhydro-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol
• 1: PN: WO2017201317 SEQID: 1 claimed DNA
• 2,4(1H,3H)-Pyrimidinedione, 5-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 5-(β-<span class="text-smallcaps">D</span>-Ribofuranosyl)uracil
• 5-Ribosyluracil
• 5-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
• 5-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione
• 5-β-D-ribofuranosyluracil
• B-Pseudouridine
• NSC 162405
• Pseudouridine
• Pseudouridine C
• Uracil, 5-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• β-<span class="text-smallcaps">D</span>-Pseudouridine
• ψ-Uridine
• Uracil, 5-β-D-ribofuranosyl-

Pseudouridine (Synthetic)

CAS: 1445-07-4

Fórmula: C₉H₁₂N₂O₆

Pureza: >98.0%(HPLC)(qNMR)

Forma y color: White to Almost white powder to crystal

Peso molecular: 244.20

Ref: 3B-P2939

Pseudouridine

CAS: 1445-07-4

Fórmula: C₉H₁₂N₂O₆

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 244.20

Ref: 3B-P2396

2,4(1H,3H)-Pyrimidinedione, 5-β-D-ribofuranosyl-

CAS: 1445-07-4

Fórmula: C₉H₁₂N₂O₆

Pureza: 98%

Forma y color: Solid

Peso molecular: 244.2014

Ref: IN-DA001JNO

Pseudouridine

CAS: 1445-07-4

Pseudouridine

Pureza: ≥98%

Peso molecular: 244.2g/mol

Ref: 54-BUP05993

Pseudouridine

CAS: 1445-07-4

Fórmula: C₉H₁₂N₂O₆

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 244.20

Ref: 7W-GN9104

Pseudouridine

CAS: 1445-07-4

Pseudouridine

Pureza: 98%

Peso molecular: 244.20g/mol

Ref: 54-OR1014849

Uridine Impurity 2 (Pseudouridine)

CAS: 1445-07-4

Fórmula: C₉H₁₂N₂O₆

Forma y color: White To Off-White Solid

Peso molecular: 244.20

Ref: 4Z-U-0130

Pseudouridine

CAS: 1445-07-4

Pseudouridine, prevalent in non-coding RNAs, boosts tRNA and rRNA function by RNA stabilization.

Fórmula: C₉H₁₂N₂O₆

Pureza: 99.3%

Forma y color: Solid

Peso molecular: 244.2

Ref: TM-T16674

β-Pseudouridine

Producto controlado

CAS: 1445-07-4

Applications An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.
References Ferré-D'Amaré A.R. et al.: Curr. Opin. Struct. Biol., 13, 49 (2003); Hamma, T. et al.: Chem. Biol., 13, 1125 (2006); Liang, X.H. et al.: RNA, 8, 237 (2002); Monobe, M. et al.: Mut. Res. Gen. Toxicol. Env. Mutagen., 538, 93 (2003);

Fórmula: C₉H₁₂N₂O₆

Forma y color: Neat

Peso molecular: 244.20

Ref: TR-P839605

β-Pseudouridine-13C, 15N2

CAS: 1445-07-4

Applications Isotope labelled β-Pseudouridine is an isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.
References Ferré-D'Amaré A.R. et al.: Curr. Opin. Struct. Biol., 13, 49 (2003); Hamma, T. et al.: Chem. Biol., 13, 1125 (2006); Liang, X.H. et al.: RNA, 8, 237 (2002); Monobe, M. et al.: Mut. Res. Gen. Toxicol. Env. Mutagen., 538, 93 (2003);

Fórmula: C₈CH₁₂N₂O₆

Forma y color: Neat

Peso molecular: 247.18

Ref: TR-P839607

Pseudouridine

CAS: 1445-07-4

Pseudouridine is a nucleoside that is produced by the deamination of uridine. It has been shown to have biological properties in vitro, and may be involved in the pathogenesis of infectious diseases. Pseudouridine has been shown to act as an allosteric ligand for toll-like receptor 4. It also has a thermodynamic stability that is higher than that of uridine, which may allow it to serve as a more stable substrate for enzymes such as ribonucleotide reductase and dTMP synthetase.

Fórmula: C₉H₁₂N₂O₆

Pureza: Min. 99.0 Area-%

Peso molecular: 244.20 g/mol

Ref: 3D-W-201269

Pseudouridine

CAS: 1445-07-4

Uridine isomer; found in tRNA

Fórmula: C₉H₁₂N₂O₆

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 244.2 g/mol

Ref: 3D-NP11297

PSEUDOURIDINE

CAS: 1445-07-4

Pureza: 98%

Forma y color: Solid

Peso molecular: 244.2030029

Ref: 10-F808110