CAS 144689-24-7

Olmesartán

Descripción:

Olmesartán es un antagonista del receptor de angiotensina II que se utiliza principalmente en el tratamiento de la hipertensión. Pertenece a la clase de medicamentos conocidos como sartanes, que actúan bloqueando la acción de la angiotensina II, una hormona que causa la constricción de los vasos sanguíneos. Esta acción conduce a la vasodilatación, lo que resulta en una disminución de la presión arterial. Químicamente, Olmesartán se caracteriza por su estructura compleja, que incluye un grupo bifenilo y un moiety carboxilato, contribuyendo a su actividad farmacológica. La sustancia se administra típicamente en forma de Olmesartán medoxomilo, un profármaco que se convierte en su forma activa en el cuerpo. Olmesartán es conocido por su larga vida media, lo que permite una dosificación una vez al día. Generalmente es bien tolerado, aunque los efectos secundarios potenciales pueden incluir mareos, dolor de cabeza y trastornos gastrointestinales. Al igual que con otros agentes antihipertensivos, es importante monitorear la función renal y los niveles de potasio durante el tratamiento. En general, Olmesartán es una opción efectiva para manejar la hipertensión y reducir el riesgo de eventos cardiovasculares.

Fórmula: C₂₄H₂₆N₆O₃

InChI: InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)

Clave InChI: InChIKey=VTRAEEWXHOVJFV-UHFFFAOYSA-N

SMILES: C(N1C(C(O)=O)=C(C(C)(C)O)N=C1CCC)C2=CC=C(C=C2)C3=C(C=CC=C3)C=4NN=NN4

Sinónimos:

• 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
• 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• 1H-Imidazole-5-carboxylicacid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
• 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
• Cs 088
• Olmesartan
• Olmetor
• Rnh 6270

Olmesartan

CAS: 144689-24-7

Forma y color: Neat

Ref: 61-FOR1317.01

1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

CAS: 144689-24-7

Fórmula: C₂₄H₂₆N₆O₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 446.5016

Ref: IN-DA001K0E

Olmesartan (Olmesartan Medoxomil EP Impurity A)

CAS: 144689-24-7

Fórmula: C₂₄H₂₆N₆O₃

Forma y color: White To Off-White Solid

Peso molecular: 446.51

Ref: 4Z-O-081

Olmesartan

CAS: 144689-24-7

Olmesartan

Pureza: ≥90%

Peso molecular: 446.5g/mol

Ref: 54-BUP13846

Olmesartan

CAS: 144689-24-7

Fórmula: C₂₉H₃₀N₆O₆

Pureza: (HPLC) ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 558.59

Ref: 7W-GP5497

1-((2'-(1H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-4-(2-Hydroxypropan-2-Yl)-2-Propyl-1H-Imidazole-5-Carboxylic Acid

CAS: 144689-24-7

1-((2'-(1H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-4-(2-Hydroxypropan-2-Yl)-2-Propyl-1H-Imidazole-5-Carboxylic Acid

Pureza: 98%

Peso molecular: 446.5g/mol

Ref: 54-OR1026226

Olmesartan-d64 Acid(dimethyl-d6)

CAS: 1185144-74-4, 144689-24-7

Pureza: 99 atom % D

Peso molecular: 452.54

Ref: 3U-D7522

Olmesartan 100 µg/mL in Acetonitrile:Methanol

Producto controlado

CAS: 144689-24-7

Fórmula: C₂₄H₂₆N₆O₃

Forma y color: Single Solution

Peso molecular: 446.50

Ref: 04-A15727200MC-100

Olmesartan

CAS: 144689-24-7

Fórmula: C₂₄H₂₆N₆O₃

Pureza: >98.0%(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 446.51

Ref: 3B-O0507

Olmesartan

CAS: 144689-24-7

Pureza: 98%

Peso molecular: 446.510986328125

Ref: 10-F787557

Olmesartan

CAS: 144689-24-7

Fórmula: C₂₄H₂₆N₆O₃

Forma y color: Neat

Peso molecular: 446.50

Ref: 04-C15727200

4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-5-carboxylic Acid (Olmesartan)

Producto controlado

CAS: 144689-24-7

Fórmula: C₂₄H₂₆N₆O₃

Forma y color: Neat

Peso molecular: 446.50

Ref: 86-MM1317.01

Olmesartan

CAS: 144689-24-7

Olmesartan (RNH 6270) is an Angiotensin II Type I receptor antagonist.

Fórmula: C₂₄H₂₆N₆O₃

Pureza: 91.89% - 99.81%

Forma y color: White To Beige Solid Solid

Peso molecular: 446.50

Ref: TM-T5964

Olmesartan Acid

CAS: 144689-24-7

Fórmula: C₂₄H₂₆N₆O₃

Ref: TR-TRC-O550001

Olmesartan Acid

Producto controlado

CAS: 144689-24-7

Impurity Olmesartan EP Impurity A
Applications Olmesartan Acid (Olmesartan EP Impurity A) is an angiotensin II receptor antagonist. Used as an anti-hypertensive.
References Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996), Puchler, K., et al.: J. Hypertens., 15, 1809 (1997),

Fórmula: C₂₄H₂₆N₆O₃

Forma y color: White To Beige

Peso molecular: 446.5

Ref: TR-O550001

Olmesartan Medoxomil EP Impurity A

CAS: 144689-24-7

Fórmula: C₂₄H₂₆N₆O₃

Peso molecular: 446.51

Ref: ST-EA-CP-O7001

Olmesartan

CAS: 144689-24-7

Olmesartan medoxomil is a prodrug that is hydrolyzed to olmesartan, its active form. It is a member of the angiotensin II receptor antagonists and it is used for the treatment of hypertension and heart failure. Olmesartan medoxomil reduces the risk of cardiovascular events in patients with resistant hypertension or heart failure. The drug binds to the angiotensin II type 1 receptor, thereby blocking the binding of angiotensin II to this receptor. This prevents activation of downstream signaling pathways, including phospholipase C, protein kinase C, and mitogen-activated protein kinases. Olmesartan medoxomil also blocks the formation of new blood vessels and vascular remodeling in animal models.

Fórmula: C₂₄H₂₆N₆O₃

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 446.5 g/mol

Ref: 3D-IH57928