CAS 146374-27-8

2-Metil-2-propanosulfinamida

Descripción:

2-Metil-2-propanosulfinamida, con el número CAS 146374-27-8, es un compuesto orgánico caracterizado por la presencia de un grupo funcional sulfinamida. Presenta una cadena alquílica ramificada, específicamente un grupo tert-butilo, que contribuye a su impedimento estérico e influye en su reactividad. Este compuesto es típicamente un líquido o sólido incoloro a amarillo pálido, dependiendo de la temperatura y la pureza. Es soluble en disolventes orgánicos polares, lo que lo hace útil en varias reacciones químicas, particularmente en la síntesis de productos farmacéuticos y agroquímicos. El grupo sulfinamida otorga propiedades químicas únicas, permitiéndole participar en reacciones de sustitución nucleofílica y servir como un posible bloque de construcción en la síntesis orgánica. Además, 2-Metil-2-propanosulfinamida puede exhibir actividades biológicas específicas, lo que lo hace de interés en la química medicinal. Se deben consultar los datos de seguridad para el manejo y almacenamiento, como con cualquier sustancia química, para asegurar que se tomen las precauciones adecuadas debido a la posible toxicidad o reactividad.

Fórmula: C₄H₁₁NOS

InChI: InChI=1S/C4H11NOS/c1-4(2,3)7(5)6/h5H2,1-3H3

Clave InChI: InChIKey=CESUXLKAADQNTB-UHFFFAOYSA-N

SMILES: C(S(N)=O)(C)(C)C

Sinónimos:

• 1,1-Dimethylethylsulfinamide
• 2-Methyl-2-Propanesulfinamide
• 2-Methyl-2-Propanesulfinamide, Racemic
• 2-Methyl-Propane-2-Sulfinic Acid Amide
• 2-Methylpropan-2-sulfinamide
• 2-Methylpropane-1-Sulfinamide
• 2-Propanesulfinamide, 2-methyl-
• Racemic Tert Butylsulfinamide
• T-Butylsulfinamide
• Tert-Butylsulfinamide
• Tert-Butylsulphinamide

tert-Butylsulfinamide

CAS: 146374-27-8

Fórmula: C₄H₁₁NOS

Pureza: >97.0%(GC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 121.20

Ref: 3B-B2926

(±)-2-Methyl-2-propanesulfinamide, 97%

CAS: 146374-27-8

()-2-Methyl-2-propanesulfinamide is used in the synthesis of 4-sulfonyliminopiperidine and its reaction with benzyl Grignard to form an important pharmaceutical building block, 4-benzyl-4-aminopiperidne. It is also used to prepare spiro tosylaziridines via methylene insertion into the derived sulfon

Fórmula: (CH₃)₃CS(O)NH₂

Pureza: 97%

Forma y color: Powder or crystalline powder or lumpy powder, White to cream to pale brown

Peso molecular: 121.2

Ref: 02-B25385

2-Propanesulfinamide, 2-methyl-

CAS: 146374-27-8

Fórmula: C₄H₁₁NOS

Pureza: 97%

Forma y color: Solid

Peso molecular: 121.2012

Ref: IN-DA00HXHN

t-Butylsulfinamide

CAS: 146374-27-8

Fórmula: C₄H₁₁NOS

Pureza: 97%

Forma y color: Solid, Powder

Peso molecular: 121.2

Ref: 10-F034514

2-Methylpropane-2-sulphinamide

CAS: 146374-27-8

2-Methylpropane-2-sulphinamide

Fórmula: C₄H₁₁NOS

Pureza: 96%

Forma y color: white solid

Peso molecular: 121.20g/mol

Ref: 54-OR301075

tert-Butylsulfinamide

Producto controlado

CAS: 146374-27-8

Applications tert-Butylsulfinamide can be readily transformed into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins. tert-Butylsulfinamide is also used as a reagent in the synthetic preparation of amide series as BACE1 inhibitor and potential anti-Alzheimer’s drug.
References Szallasi, A., et al.: Pharmacol. Rev., 51, 159 (1999), Montell, C., et al.: Mol. Cell., 9, 229 (2002), Ryu, C., et al.: Bioorg. Med. Chem. Lett., 14, 1751 (2004), Suh, Y., et al.: J. Med. Chem., 48, 5823 (2005); Woltering, T. J., et al.: Bioorg. Med. Chem. Lett., 23, 4239 (2013)

Fórmula: C₄H₁₁NOS

Forma y color: Neat

Peso molecular: 121.2

Ref: TR-B693900

tert-Butylsulfinamide

CAS: 146374-27-8

tert-Butylsulfinamide is a model system for the synthesis of enantiopure amines and esters. The synthesis of tert-butylsulfinamide starts with the reaction of an allyl bromide with a sulfinic acid chloride to form an allyl sulfonate, which is then hydrolyzed to produce tert-butylsulfinamide. The yield for this type of reaction is usually low, but tert-butylsulfinamide can be isolated in good yields if it is prepared in a stereoselective manner. Tert-butylsulfinamide has been shown to inhibit the growth of human hair follicles in cell culture experiments, which may be due to its ability to inhibit the formation of hydrogen peroxide by inhibiting an enzyme called tyrosine hydroxylase.

Fórmula: C₄H₁₁NOS

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 121.2 g/mol

Ref: 3D-FB61266