CAS 146478-72-0

(2Z,4S)-4-(Acetiloxi)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihidroxi-7-metil-1,6-dioxaspiro[2.5]oct-5-il]-3-metil-2,4-pentadien-1-il]tetrahidro-2,5-dimetil-2H-piran-3-il]-2-pentenamida

Descripción:

La sustancia química con el nombre "(2Z,4S)-4-(Acetiloxi)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihidroxi-7-metil-1,6-dioxaspiro[2.5]oct-5-il]-3-metil-2,4-pentadien-1-il]tetrahidro-2,5-dimetil-2H-piran-3-il]-2-pentenamida" y el número CAS "146478-72-0" es un compuesto orgánico complejo caracterizado por múltiples grupos funcionales y estereocentros. Presenta un grupo acetyloxy, lo que sugiere una reactividad y solubilidad potencial en disolventes orgánicos. La presencia de una estructura dioxaspiro indica un arreglo cíclico único que puede contribuir a su actividad biológica. El compuesto también contiene múltiples centros quirales, que pueden influir en su estereoquímica e interacciones con sistemas biológicos. Su estructura sugiere aplicaciones potenciales en farmacéuticos o como un compuesto bioactivo, aunque las actividades biológicas específicas requerirían una investigación adicional. El intrincado arreglo de cadenas de carbono y grupos funcionales destaca su complejidad, convirtiéndolo en un tema de interés en la química orgánica sintética y la investigación en química medicinal.

Fórmula: C₂₇H₄₁NO₈

InChI: InChI=1S/C27H41NO8/c1-16(8-11-23-25(31)27(15-33-27)14-26(6,32)36-23)7-10-22-17(2)13-21(19(4)35-22)28-24(30)12-9-18(3)34-20(5)29/h7-9,11-12,17-19,21-23,25,31-32H,10,13-15H2,1-6H3,(H,28,30)/b11-8+,12-9-,16-7+/t17-,18-,19+,21+,22-,23+,25+,26-,27+/m0/s1

Clave InChI: InChIKey=PJKVJJDQXZARCA-QHYZBLTGSA-N

SMILES: O[C@H]1[C@]2(CO2)C[C@@](C)(O)O[C@@H]1/C=C/C(=C/C[C@H]3[C@@H](C)C[C@@H](NC(/C=C\[C@@H](OC(C)=O)C)=O)[C@@H](C)O3)/C

Sinónimos:

• 2-Pentenamide, 4-(acetyloxy)-N-[6-[5-(4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl)-3-methyl-2,4-pentadienyl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, [3R-[3R*,4R*,5R*[1[2R*,3R*(2Z,4S*),5S*,6S*],2E,4E],7S*]]-
• (2Z,4S)-4-(Acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-2-pentenamide
• WB 2663B
• 2-Pentenamide, 4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadienyl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, (2Z,4S)-
• 2-Pentenamide, 4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, (2Z,4S)-

FR901464

CAS: 146478-72-0

FR901464 (WB 2663B) is potent cytotoxic natural products that share an amine-containing tetrahydropyran ring.

Fórmula: C₂₇H₄₁NO₈

Pureza: 98.47%

Forma y color: Solid

Peso molecular: 507.62

Ref: TM-T31866

FR901464

CAS: 146478-72-0

FR901464

Pureza: ≥98%

Peso molecular: 507.62g/mol

Ref: 54-BUP01121

FR 901464

CAS: 146478-72-0

FR 901464 is a cytotoxic compound that inhibits the activity of the mammalian splicing factor receptor (SFRS2), which is involved in the splicing process. The active form of FR 901464 binds to SFRS2 and prevents it from binding to other proteins, thereby inhibiting the formation of functional complexes. This leads to an increase in the production of proteins that are not targeted for degradation and a decrease in the production of proteins targeted for degradation. This drug also has anti-inflammatory properties by inhibiting epidermal growth factor (EGF) and its receptor, EGF-R. It also has antimicrobial effects against some bacteria by inhibiting bacterial growth factors such as amide or conjugates.

Fórmula: C₂₇H₄₁NO₈

Pureza: Min. 95%

Peso molecular: 507.6 g/mol

Ref: 3D-WFA47872