CAS 1476-52-4

(±)-Desetilcloroquina

Descripción:

(±)-Desetilcloroquina es un compuesto químico que es un derivado de la cloroquina, conocido principalmente por su uso como agente antipalúdico. Esta sustancia se caracteriza por su modificación estructural, específicamente la eliminación del grupo etilo de la molécula de cloroquina. Presenta propiedades que pueden influir en su actividad farmacológica, incluidos posibles efectos antivirales. El compuesto tiene un centro quiral, lo que lleva a la existencia de enantiómeros, que pueden exhibir diferentes actividades biológicas. (±)-Desetilcloroquina es soluble en disolventes orgánicos y tiene una solubilidad limitada en agua, lo que puede afectar su biodisponibilidad y eficacia terapéutica. Se piensa que su mecanismo de acción implica la interferencia con el proceso de polimerización de hemo en los parásitos de la malaria, así como una posible modulación de las respuestas inmunitarias. La investigación sobre su farmacocinética, perfil de seguridad y aplicaciones terapéuticas continúa, particularmente en el contexto de enfermedades infecciosas emergentes. Al igual que con muchos compuestos farmacéuticos, comprender sus características es crucial para desarrollar protocolos de tratamiento efectivos.

Fórmula: C₁₆H₂₂ClN₃

InChI: InChI=1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)

Clave InChI: InChIKey=MCYUUUTUAAGOOT-UHFFFAOYSA-N

SMILES: N(C(CCCNCC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2

Sinónimos:

• (±)-Desethylchloroquine
• 1,4-Pentanediamine N4-(7-chloro-4-quinolinyl)-N1-ethyl-
• 1,4-Pentanediamine, N⁴-(7-chloro-4-quinolinyl)-N¹-ethyl-
• 4-[[1-Methyl-4-((ethylamino)butyl]amino)]-7-chloroquinoline
• 7-Chloro-4-(4-N-ethylamino-1-methylbutylamino)quinoline
• Chloroquine, deethyl-
• Deethylchloroquine
• Monodeethylchloroquine
• Monodesethylchloroquine
• N-Deethylchloroquine
• N4-(7-Chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine
• N⁴-(7-Chloro-4-quinolinyl)-N¹-ethyl-1,4-pentanediamine
• Nsc 13254
• N~4~-(7-chloroquinolin-4-yl)-N~1~-ethylpentane-1,4-diamine
• Quinoline, 7-chloro-4-[[4-(ethylamino)-1-methylbutyl]amino]-

Chloroquine Related Compound D (7-Chloro-4-{[4-(ethylamino)-1-methylbutyl] amino} quinoline)

CAS: 1476-52-4

Compounds (excluding drugs and pesticides) containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused, nesoi

Fórmula: C₁₆H₂₂ClN₃

Forma y color: Tan Powder

Peso molecular: 291.15023

Ref: 45-1118350

1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1-ethyl-

CAS: 1476-52-4

Fórmula: C₁₆H₂₂ClN₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 291.8190

Ref: IN-DA001F0N

Desethyl chloroquine

CAS: 1476-52-4

Desethyl chloroquine

Pureza: ≥98%

Peso molecular: 291.82g/mol

Ref: 54-BUP17493

Hydroxychloroquine Sulfate EP Impurity D HBr (Chloroquine USP Related Compound D HBr, Desethyl Chloroquine HBr)

CAS: 1476-52-4

Fórmula: C₁₆H₂₂ClN₃·HBr

Forma y color: White To Off-White Solid

Peso molecular: 291.82 80.91

Ref: 4Z-H-0640

Hydroxychloroquine Sulfate EP Impurity D (Chloroquine USP Related Compound D, Desethyl Chloroquine)

CAS: 1476-52-4

Fórmula: C₁₆H₂₂ClN₃

Forma y color: White To Off-White Solid

Peso molecular: 291.82

Ref: 4Z-H-0638

Desethyl chloroquine

CAS: 1476-52-4

Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.

Fórmula: C₁₆H₂₂ClN₃

Pureza: 99.56%

Forma y color: Solid

Peso molecular: 291.82

Ref: TM-T11001

Hydroxychloroquine Sulfate EP Impurity D DiHBr (Chloroquine USP Related Compound D DiHBr, Desethyl Chloroquine DiHBr)

CAS: 1476-52-4

Fórmula: C₁₆H₂₂ClN₃·2HBr

Forma y color: White To Off-White Solid

Peso molecular: 291.82 2*80.91

Ref: 4Z-H-0618

Hydroxychloroquine Sulfate EP Impurity D TriHCl (Chloroquine USP Related Compound D TriHCl, Desethyl Chloroquine TriHCl)

CAS: 1476-52-4

Fórmula: C₁₆H₂₂ClN₃·3HCl

Peso molecular: 291.83 3*36.46

Ref: 4Z-H-0665

Desethyl Chloroquine

Producto controlado

CAS: 1476-52-4

Applications Desethyl Chloroquine is the major product of the stereoselective human metabolism of Chloroquine, used for the therapy and prevention of malaria. It is a COVID19-related research product.
References Essien, E., et al.: J. Pharm. Pharmacol., 38, 543 (1986), Akintonwa, A., et al.: Ther. Drug Monit., 10, 147 (1988), Boelaert, J., et al.: AIDS, 15, 2205 (2001), Basco, L., et al.: Antimicrob. Agents Chemother., 47, 1391 (2003),

Fórmula: C₁₆H₂₂ClN₃

Forma y color: Light Yellow To Dark Yellow

Peso molecular: 291.82

Ref: TR-D288735

Desethyl chloroquine

CAS: 1476-52-4

Desethyl chloroquine is a drug that is used to treat malaria and other infectious diseases. It is an antimalarial drug that has been shown to be effective in the treatment of malaria and related diseases such as toxoplasmosis, amebiasis, trypanosomiasis, and leishmaniasis. Methods for the preparation of desethyl chloroquine are described in the analytical section. To measure the concentration of desethyl chloroquine in blood, it is recommended to collect a sample of blood by venipuncture or fingerstick. The concentration-time curve in blood can be analyzed using a fluorescence detector and LC-MS/MS method. When analyzing pharmacokinetic properties, it is important to take into account the matrix effect due to human serum proteins. Desethyl chloroquine has potent inducers that affect its pharmacokinetics and metabolism, including CYP3A4 enzymes and glutathione reductase.

Fórmula: C₁₆H₂₂ClN₃

Pureza: Min. 95%

Forma y color: Slightly Yellow Powder

Peso molecular: 291.82 g/mol

Ref: 3D-FD21174