CAS 147664-63-9

Pexiganan

Descripción:

Pexiganan es un péptido antimicrobiano sintético que se utiliza principalmente por sus propiedades antibacterianas, particularmente contra bacterias Gram-negativas. Se deriva de la familia de péptidos magainina, que se encuentran de forma natural en la piel de ciertos anfibios. Pexiganan exhibe un amplio espectro de actividad, lo que lo hace efectivo en el tratamiento de infecciones, especialmente en formulaciones tópicas para heridas. El mecanismo de acción implica la interrupción de las membranas celulares bacterianas, lo que lleva a la lisis celular. Este péptido se caracteriza por su tamaño relativamente pequeño, que típicamente consiste en alrededor de 22 aminoácidos, y su naturaleza catiónica, que mejora su interacción con las membranas bacterianas cargadas negativamente. Pexiganan también es notable por su estabilidad y resistencia a la degradación proteolítica, lo que contribuye a su eficacia en aplicaciones clínicas. Su desarrollo se ha centrado particularmente en abordar la creciente preocupación por la resistencia a los antibióticos, proporcionando un enfoque alternativo a las terapias antibióticas tradicionales. En general, Pexiganan representa un candidato prometedor en el campo de los agentes antimicrobianos, particularmente para uso tópico.

Fórmula: C₁₂₂H₂₁₀N₃₂O₂₂

InChI: InChI=1/C122H210N32O22/c1-13-77(9)102(152-98(155)71-132)120(174)135-73-100(157)139-86(50-26-35-59-125)110(164)150-96(69-82-44-20-16-21-45-82)118(172)148-93(66-74(3)4)116(170)145-90(54-30-39-63-129)113(167)142-87(51-27-36-60-126)109(163)137-79(11)105(159)141-88(52-28-37-61-127)112(166)143-91(55-31-40-64-130)114(168)149-95(68-81-42-18-15-19-43-81)107(161)134-72-99(156)138-85(49-25-34-58-124)108(162)136-80(12)106(160)147-97(70-83-46-22-17-23-47-83)119(173)153-101(76(7)8)121(175)146-92(56-32-41-65-131)115(169)154-103(78(10)14-2)122(176)151-94(67-75(5)6)117(171)144-89(53-29-38-62-128)111(165)140-84(104(133)158)48-24-33-57-123/h15-23,42-47,74-80,84-97,101-103H,13-14,24-41,48-73,123-132H2,1-12H3,(H2,133,158)(H,134,161)(H,135,174)(H,136,162)(H,137,163)(H,138,156)(H,139,157)(H,140,165)(H,141,159)(H,142,167)(H,143,166)(H,144,171)(H,145,170)(H,146,175)(H,147,160)(H,148,172)(H,149,168)(H,150,164)(H,151,176)(H,152,155)(H,153,173)(H,154,169)/t77-,78-,79-,80-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,101-,102-,103-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccccc1)C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](C)C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](C(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H]([C@@H](C)CC)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(CN)O

Sinónimos:

• Pexiganan [INN]
• Glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-L-lysinamide
• Magainin I, 7-L-lysine-8-L-lysine-10-L-lysine-18-L-lysine-19-de-L-glutamic acid-21-L-leucine-23-L-lysinamide
• L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylaalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-

Pexiganan

CAS: 147664-63-9

Pexiganan, a synthetic magainin 2 analog, is a broad-spectrum antimicrobial peptide for researching infections like diabetic foot ulcers.

Fórmula: C₁₂₂H₂₁₀N₃₂O₂₂

Forma y color: Solid

Peso molecular: 2477.17

Ref: TM-T73653

Pexiganan

CAS: 147664-63-9

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Fórmula: C₁₂₂H₂₁₀N₃₂O₂₂

Peso molecular: 2,477.21 g/mol

Ref: 3D-PP50033

Pexiganan acetate

Producto controlado

CAS: 147664-63-9

Pexiganan acetate is the acetate salt form of a polymyxin B derivative that has potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It has been shown to be effective in the treatment of tissue infections, especially those caused by human pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Pexiganan also has significant activity against Mycobacterium tuberculosis and other mycobacteria. The mechanism of action for pexiganan is not fully understood but it may involve the inhibition of bacterial cell wall synthesis, or the disruption of bacterial membranes. Pexiganan was originally isolated from a marine sponge off the coast of Australia in 1961. It had been classified as an antimicrobial peptide (AMP) because of its chemical structure, which includes a polymyxin B moiety. Pexiganan’s AMP classification was later challenged when researchers found that it did

Fórmula: C₁₂₂H₂₁₀N₃₂O₂₂•(C₂H₄O₂)x

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 2,477.18 g/mol

Ref: 3D-FP182746

Pexiganan

CAS: 147664-63-9

Pexiganan is a polymyxin B derivative that has potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It has been shown to be effective in the treatment of tissue infections, especially those caused by human pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Pexiganan also has significant activity against Mycobacterium tuberculosis and other mycobacteria. The mechanism of action for pexiganan is not fully understood but it may involve the inhibition of bacterial cell wall synthesis, or the disruption of bacterial membranes. Pexiganan was originally isolated from a marine sponge off the coast of Australia in 1961. It had been classified as an antimicrobial peptide (AMP) because of its chemical structure, which includes a polymyxin B moiety. Pexiganan’s AMP classification was later challenged when researchers found that it did

Fórmula: C₁₂₂H₂₁₀N₃₂O₂₂

Pureza: Min. 95%

Peso molecular: 2,477.18 g/mol

Ref: 3D-FP138116