CAS 147794-23-8

omega-conotoxina mviic

Descripción:

La omega-conotoxina MVIIA es un péptido derivado del veneno del caracol Conus, específicamente del Conus magus. Es un bloqueador potente y selectivo de los canales de calcio dependientes de voltaje de tipo N (VGCC), que desempeñan un papel crucial en la liberación de neurotransmisores y la señalización del dolor. Esta característica hace que la omega-conotoxina MVIIA sea de gran interés en farmacología, particularmente por sus posibles aplicaciones en el manejo del dolor y la investigación neurológica. El péptido consiste en una secuencia específica de aminoácidos que contribuye a su estructura y función únicas. Exhibe alta afinidad por los canales de calcio de tipo N, inhibiendo la entrada de calcio y reduciendo así la liberación de neurotransmisores, lo que puede aliviar el dolor. La omega-conotoxina MVIIA también se estudia por sus posibles efectos terapéuticos en varios trastornos neurológicos. Debido a su origen en organismos marinos, representa un ejemplo fascinante de cómo los productos naturales pueden llevar al desarrollo de nuevos agentes farmacológicos. Su estabilidad y especificidad la convierten en una herramienta valiosa tanto en la investigación como en aplicaciones clínicas potenciales.

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Sinónimos:

• w-Conotoxin MVIIC, Conus magus
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2 (Disulfide bonds between Cys1 and Cys16/Cys8 and Cys20/ Cys15 and Cys26)
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2 (Disulfide Bridge: 1-16, 8-20, And 15-26)
• Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2
• Ckgkgapcrktmydccsgscgrrgkc-Nh2 (Disulfide Bridge: 1-16,8-20 And 15-26)
• Omega-Cgtx Mviic
• Omega-Conotoxin Mviic, Conus Magus

ω-Conotoxin MVIIC

CAS: 147794-23-8

Like ω-conotoxin GVIA, this Conus magus peptide inhibits presynaptic Ca²⁺ channels. However, ω-conotoxin MVIIC clearly inhibits additional Ca²⁺ channel subtypes in the mammalian central nervous system. Thus, it should become a standard pharmacological reagent for investigating synaptic transmission in the mammalian nervous system.

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Pureza: > 98%

Forma y color: White Powder

Peso molecular: 2749.29

Ref: 01-4030522

ω-Conotoxin MVIIC

CAS: 147794-23-8

Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Pureza: 98%

Forma y color: White Lyophilised Solid

Peso molecular: 2749

Ref: TM-TP2064

ω-Conotoxin MVIIC

CAS: 147794-23-8

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Peso molecular: 2749.25

Ref: 7W-GK3612

Omega-Conotoxin MVIIC

CAS: 147794-23-8

Omega-Conotoxin MVIIC is a peptide that binds to the nicotinic acetylcholine receptor and activates it, leading to inhibition of neurotransmitter release. It is used as a research tool for studying the pharmacology of ion channels and their ligands. Omega-Conotoxin MVIIC is purified from Conus magus venom. The peptide has been shown to be an inhibitor of potassium channels in rat cortical neurons. CONOTOXINS are small peptides that bind to the nicotinic acetylcholine receptor and activate it, leading to inhibition of neurotransmitter release. They are used as research tools for studying the pharmacology of ion channels and their ligands. CONOTOXINS are purified from Conus magus venom. The peptide has been shown to be an inhibitor of potassium channels in rat cortical neurons.END> END>

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Pureza: Min. 95%

Peso molecular: 2,749.3 g/mol

Ref: 3D-PCN-4283-S

ω-Conotoxin MVIIC

CAS: 147794-23-8

Omega-conotoxins are a group of peptides found in the venom of predatory marine snails. Omega-conotoxin MVIIC is a potent inhibitor of nicotinic acetylcholine receptors. It blocks the activation and desensitization of nicotinic acetylcholine receptor channels and has been used as a research tool to study the function of these proteins. Omega-conotoxin MVIIC binds to its target by interacting with specific sites on the alpha subunit of nicotinic acetylcholine receptor channels, which leads to inhibition of voltage-gated calcium channels. The high purity and low endotoxin levels make this product suitable for life science research applications.

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Pureza: Min. 95%

Peso molecular: 2,749.3 g/mol

Ref: 3D-PCN-4283-V

Omega-Conotoxin MVIIC

Producto controlado

CAS: 147794-23-8

Omega-Conotoxin MVIIC is a peptide toxin that blocks the voltage-dependent calcium channels. It has been shown to have neuroprotective properties and to inhibit glutamate induced neurotoxicity in vitro and in vivo. Omega-Conotoxin MVIIC inhibits neurotransmitter release by blocking the calcium channels and thereby reduces oxidative stress, which prevents neuronal cell death. This toxin also blocks the activity of voltage-dependent sodium channels, but its effects are not as potent as those on calcium channels. Omega-Conotoxin MVIIC has been found to be effective against cerebellar granule neurons, as well as other neurons in the brainstem, cerebellum, hippocampus, and cerebral cortex. The molecular weight of this toxin is approximately 10 kDa and it contains subunits (a total of eight).

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 2,749.26 g/mol

Ref: 3D-FC110353