CAS 148408-66-6

trihidrato de docetaxel

Descripción:

trihidrato de docetaxel es un agente quimioterapéutico semisintético derivado del tejo, específicamente del compuesto paclitaxel. Se utiliza principalmente en el tratamiento de varios tipos de cáncer, incluidos el cáncer de mama, pulmón y próstata. La sustancia se caracteriza por su capacidad para inhibir la división celular al estabilizar los microtúbulos, evitando así la descomposición normal del huso mitótico durante la división celular. trihidrato de docetaxel se administra típicamente por vía intravenosa y es conocido por su efectividad en la promoción de la apoptosis en células cancerosas. En términos de propiedades físicas, aparece como un polvo cristalino blanco a blanco sucio, y su forma de trihidrato indica la presencia de tres moléculas de agua asociadas con cada molécula de docetaxel. El compuesto es soluble en disolventes orgánicos como el etanol y el dimetilsulfóxido, pero tiene una solubilidad limitada en agua. Su farmacocinética implica un extenso metabolismo en el hígado, principalmente a través de las enzimas del citocromo P450, y se excreta principalmente a través de la bilis. Al igual que muchos agentes quimioterapéuticos, trihidrato de docetaxel puede tener efectos secundarios significativos, incluidos neutropenia, fatiga y trastornos gastrointestinales.

Fórmula: C₄₃H₅₃NO₁₄·3H₂O

InChI: InChI=1S/C43H53NO14.3H2O/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45;;;/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52);3*1H2/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+;;;/m0.../s1

Clave InChI: InChIKey=XCDIRYDKECHIPE-QHEQPUDQSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(OC(C)(C)C)=O)C6=CC=CC=C6)O)=O)C5)[H].O

Sinónimos:

• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (betaS)-, hydrate (1:3)
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, hydrate (1:3), (αR,βS)-
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, trihydrate, (αR,βS)-
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester trihydrate, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Docetaxel・Trihydrate
• Taxespira
• Docetaxel.Trihydrate
• Docetaxel trihydrate
• Docetaxel(Trihydrate)

DOCETAXEL TRIHYDRATE CRS

CAS: 148408-66-6

DOCETAXEL TRIHYDRATE CRS

Fórmula: C₄₃H₅₃NO₁₄

Forma y color: Crystalline Powder. White. Powder.

Peso molecular: 807.8792

Ref: 41-Y0001133

DOCETAXEL FOR SYSTEM SUITABILITY CRS

CAS: 148408-66-6

DOCETAXEL FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001155

Docetaxel ((2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate trihydrate)

CAS: 148408-66-6

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Fórmula: C₄₃H₅₃NO₁₄·3H₂O

Forma y color: White Powder

Peso molecular: 807.34661

Ref: 45-1224551

Docetaxel trihydrate

CAS: 148408-66-6

Docetaxel trihydrate

Pureza: ≥98%

Peso molecular: 861.95g/mol

Ref: 54-BUP16556

Docetaxel Impurity 78

CAS: 148408-66-6

Fórmula: C₄₃H₅₁NO₁₄

Peso molecular: 805.87

Ref: 4Z-D-1919

Docetaxel Trihydrate

Producto controlado

CAS: 148408-66-6

Fórmula: C₄₃H₅₃NO₁₄H₂O

Forma y color: Neat

Peso molecular: 861.93

Ref: 86-MM3396.00

Docetaxel RS

CAS: 148408-66-6

Forma y color: White Solid Crystalline Powder

Ref: 2K-1090300021

Docetaxel Crotonaldehyde Analog

Producto controlado

CAS: 148408-66-6

Fórmula: C₄₃H₅₁NO₁₄

Forma y color: Neat

Peso molecular: 805.86

Ref: TR-D525620

Docetaxel-d5

Producto controlado

CAS: 148408-66-6

Applications A labelled semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antineoplastic.
References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)

Fórmula: C₄₃D₅H₄₈NO₁₄

Forma y color: Neat

Peso molecular: 812.91

Ref: TR-D494423

Docetaxel trihydrate

CAS: 148408-66-6

A cytotoxic taxane and anti-microtubule agent with anti-proliferative activity. Docetaxel binds to the β-subunit of tubulin, which results in increased polymerisation and stabilisation of microtubules. The compound interferes with microtubule dynamics, which leads to the cell cycle arrest in the G2/M phase and apoptosis. The compound has significant inhibitory activity in solid tumors either alone or in combination with other chemotherapeutic agents.

Fórmula: C₄₃H₅₃NO₁₄•(H₂O)₃

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 861.93 g/mol

Ref: 3D-FD29606

Docetaxel trihydrate - Bio-X ™

CAS: 148408-66-6

Docetaxel is a cytotoxic semi-synthetic taxane and is an anthracycline antibiotic. The compound is an anti-microtubule agent and has significant inhibitory activity in solid tumors either alone or in combination with other chemotherapeutic agents.
Docetaxel trihydrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₄₃H₅₃NO₁₄•(H₂O)₃

Pureza: Min. 90 Area-%

Peso molecular: 861.93 g/mol

Ref: 3D-BD164375

Docetaxel trihydrate

CAS: 148408-66-6

Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis.

Fórmula: C₄₃H₅₉NO₁₇

Pureza: 98.68% - >99.99%

Forma y color: White Crystalline Powder

Peso molecular: 861.95

Ref: TM-T0186