CAS 14930-96-2

Citochalasin B

Descripción:

Citochalasin B es un alcaloide que se encuentra de forma natural y se deriva de varias especies de hongos, particularmente del género *Helminthosporium*. Se conoce por su capacidad para inhibir la polimerización de la actina, lo que interrumpe la dinámica del citoesqueleto y afecta la motilidad, división y forma celular. Este compuesto tiene una fórmula molecular de C_22H_29N_3O_5 y presenta una estructura compleja que incluye un anillo de lactona y múltiples grupos funcionales. Citochalasin B se utiliza a menudo en investigaciones biológicas para estudiar procesos celulares, particularmente en los campos de la biología celular y la farmacología. Su mecanismo de acción implica unirse al extremo en forma de barra de los filamentos de actina, impidiendo su elongación. Además, se ha investigado para aplicaciones terapéuticas potenciales, aunque su uso está principalmente limitado a entornos de laboratorio debido a sus efectos citotóxicos. Se necesitan precauciones de seguridad al manejar Citochalasin B, ya que puede tener efectos significativos en las funciones celulares y puede representar riesgos para la salud si no se gestiona adecuadamente.

Fórmula: C₂₉H₃₇NO₅

InChI: InChI=1/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22+,23+,24?,26?,27-,29-/m1/s1

Clave InChI: InChIKey=GBOGMAARMMDZGR-TYHYBEHESA-N

SMILES: O=C1[C@]23[C@]([C@H](CC4=CC=CC=C4)N1)([C@H](C)C(=C)[C@@H](O)[C@@]2(/C=C/C[C@H](C)CCC[C@@H](O)\C=C\C(=O)O3)[H])[H]

Sinónimos:

• (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• (3E,5S,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• (3E,5S,9R,11E,12aS,13S,15S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-16-Benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2H-oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione
• 10-fenil-7(S),20(R)-dihidroxi-16(R)-metil-24-oxa[14]citochalasa-6(12),13(E),21(E)-trieno-1,23-diona
• 16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• 24-Oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione, 7,20-dihydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)-
• 2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E)-(5S,9R,12aS,13S,15S,15aS,16aS,18aS)-
• 2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-
• 2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-
• 2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-
• 2H-Oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5R,9R,12aS,13S,15S,15aS,16S,18aS)-
• 2H-Oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, [5R-(3E,5R*,9R*,11E,12aS*,13S*,15S*,15aS*,16S*,18aS*)]-
• 7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
• 7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-trien-1,23-dion
• 7,20-Dihydroxy-10-phenyl-5,16-dimethyl-24-oxa-(14)cytochalas-6(12),13,21-trien-23-one
• Brn 1096207
• Ccris 9284
• Hsdb 3479
• Nsc 107658
• Phomin
• Cytochalasin B
• CYTOCHALASIN B SYNTHETIC >97%
• 2h-oxacyclotetradec(2,3-d)isoindole-2,18(5h)-dione,16-benzyl-6,7,8,9,10,12a,13
• (7s,13e,16r,20r,21e)-0-phenyl
• CYTOCHALICINB
• cytochalasin
• CYTOCHALACINB
• cytochalasin b from drechslera dematioidea
• ,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-,(e)-(
• 9r,12as,13s,15s,15as,16as,18as)-5
• 7,20-dihydroxy-10-phenyl-5,16-dimethyl-24-oxa-[14]cytochalas-6(12),13,21-trien
• ,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2h-oxacyclotetrad
• CYTOCHALASIN B, HELMINTHOSPORIUM DEMATIOIDEUM
• CytochalasinB from Drechslera dematioidea,Phomin
• (E,E)-16-BENZYL-6,7,8,9,10,12A,13,14,15,15A,16,17-DODECAHYDRO-5,13-DIHYDROXY-9,15-DIMETHYL-14-METHYLENE-2H-OXACYCLOTETRADE[2,3-D]ISOINDOLE-2,18(5H)-DIONE
• 9r,12as,13s,15s,15as,16s,18as)--(5
• Cytochalasin B, froM Drechslera deMatoidea
• Cytochalasin beta,helminthosporium dematioideum
• CYTOCHALASIN B FROM HELMINTHOSPORIUM DEMATIODEUM
• Cytochalasin B (7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
• CYTOCHALASIN B(RG)
• CYTOCHALASIN B FROM DRESCHSLERA DEMATIOIDEA, BIOCHEMIKA, >= 95.0% (HPLC)
• ,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-,(e,e)
• CYTOCHALASIN B FROM DRESCHSLERA DEMATIOIDEA
• 3-d)isoindole-2,18(5h)-dione,16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-2h-oxacyclotetradec(
• (e,e)-(5s,9r,12as,13s,15s,15as,16s,18as)-16-benzyl-6,7,8,9,10,12a,13,14,15,15a
• 24-oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione,7,20-dihydroxy-16-methyl-1
• (7S,13E,16R,20R,21E)-7,20-Dihydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13,21-triene-1,23-dione
• ec[2,3-d]isoindole-2,18(5h)-dione
• (7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
• Cytochalasin B from Helminthosporium dematioideum

Cytochalasin B

CAS: 14930-96-2

An actin-disrupting agent

Fórmula: C₂₉H₃₇NO₅

Forma y color: Powder

Peso molecular: 479.61

Ref: 02-J65342

Cytochalasin B

CAS: 14930-96-2

Cytochalasin B

Fórmula: C₂₉H₃₇NO₅

Pureza: By hplc: 99.35% (Typical Value in Batch COA)

Forma y color: white powder

Peso molecular: 479.60777g/mol

Ref: 54-BIC1014

Cytochalasin B

CAS: 14930-96-2

Fórmula: C₂₉H₃₇NO₅

Pureza: 95%~99%

Peso molecular: 479.617

Ref: BP-SBP03783

Cytochalasin B

CAS: 14930-96-2

Fórmula: C₂₉H₃₇NO₅

Pureza: (HPLC) ≥ 97.0%

Forma y color: White to off-white powder

Peso molecular: 479.61

Ref: 7W-GA2080

Cytochalasin B

Producto controlado

CAS: 14930-96-2

Applications Cytochalasin B is a fungal metabolic toxin that preferentially damages malignant cells. Microfilament-disrupting agent which inhibites cytokinesis and produces enlarged neoplastic cells. Apoptotic agent.
References Trendowski, M. et al.: Anticanc. Res., 35, 65 (2015);

Fórmula: C₂₉H₃₅N₀₅

Forma y color: Neat

Peso molecular: 477.6

Ref: TR-C998680

Cytochalasin B

CAS: 14930-96-2

Blocker of the actin monomers to the actin filament

Fórmula: C₂₉H₃₇NO₅

Pureza: Min. 95%

Forma y color: White/Off-White Solid

Peso molecular: 479.61 g/mol

Ref: 3D-FC11288

Cytochalasin B

CAS: 14930-96-2

Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).

Fórmula: C₂₉H₃₇NO₅

Pureza: 98.79% - ＞99.99%

Forma y color: Felted Needles From Acetone Powder

Peso molecular: 479.61

Ref: TM-T7097