CAS 149647-78-9

Vorinostat

Descripción:

Vorinostat, también conocido por su nombre químico ácido hidroxámico suberoylanilida (SAHA), es un inhibidor de la histona desacetilasa (HDAC) utilizado principalmente en la terapia del cáncer. Se clasifica como un agente antineoplásico y es particularmente efectivo en el tratamiento del linfoma cutáneo de células T (CTCL). Vorinostat actúa alterando la expresión de genes involucrados en la regulación del ciclo celular y la apoptosis, lo que lleva a la inducción de la diferenciación celular y la muerte en células cancerosas. El compuesto se caracteriza por su grupo funcional ácido hidroxámico, que es crucial para su actividad inhibidora de HDAC. Vorinostat se administra típicamente por vía oral y es conocido por sus efectos secundarios, que pueden incluir fatiga, trastornos gastrointestinales y cambios hematológicos. Su farmacocinética implica un metabolismo extenso, principalmente en el hígado, y tiene una vida media relativamente corta. El desarrollo de Vorinostat marcó un avance significativo en la terapia epigenética, destacando el potencial de dirigir modificaciones de histonas en el tratamiento del cáncer.

Fórmula: C₁₄H₂₀N₂O₃

InChI: InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)

Clave InChI: InChIKey=WAEXFXRVDQXREF-UHFFFAOYSA-N

SMILES: N(C(CCCCCCC(NO)=O)=O)C1=CC=CC=C1

Sinónimos:

• Ccris 8456
• M344
• N-Hydroxy-N'-phenyloctanediamide
• N-Hyrdroxy-N'-phenyloctanediamide
• N¹-Hydroxy-N⁸-phenyloctanediamide
• Octanediamide, N-hydroxy-N'-phenyl-
• Octanediamide, N¹-hydroxy-N⁸-phenyl-
• SAHA cpd
• Suberanilohydroxamic acid
• Suberoyl anilide bishydroxamide
• Suberoylanilide Hydroxamic Acid
• Unii-58Ifb293Ji
• Vorinostat [USAN]
• Wt 171
• Zolinza
• Octanediamide, N1-hydroxy-N8-phenyl-
• SAHA

N-Hydroxy-N'-phenyloctanediamide

CAS: 149647-78-9

Fórmula: C₁₄H₂₀N₂O₃

Pureza: >98.0%(HPLC)(N)

Forma y color: White to Light yellow to Light orange powder to crystal

Peso molecular: 264.33

Ref: 3B-H1388

N-Hydroxy-N'-phenyloctanediamide

CAS: 149647-78-9

Fórmula: C₁₄H₂₀N₂O₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 264.3202

Ref: IN-DA00382H

Vorinostat

CAS: 149647-78-9

Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11.

Fórmula: C₁₄H₂₀N₂O₃

Pureza: 99.47% - 99.65%

Forma y color: White Crystalline Solid

Peso molecular: 264.32

Ref: TM-T1583

Vorinostat

CAS: 149647-78-9

Fórmula: C₁₄H₂₀N₂O₃

Forma y color: White To Off-White Solid

Peso molecular: 264.33

Ref: 4Z-V-071

Vorinostat-d5

CAS: 149647-78-9

Fórmula: C₁₄H₂₀N₂O₃

Peso molecular: 269.36

Ref: 4Z-V-072

N-Hydroxy-N'-Phenyloctanediamide

CAS: 149647-78-9

N-Hydroxy-N'-Phenyloctanediamide

Pureza: 99%

Peso molecular: 264.32g/mol

Ref: 54-OR1014396

Vorinostat

CAS: 149647-78-9

Vorinostat

Pureza: ≥98%

Peso molecular: 264.32g/mol

Ref: 54-BUP17865

Vorinostat

Producto controlado

CAS: 149647-78-9

Fórmula: C₁₄H₂₀N₂O₃

Forma y color: Neat

Peso molecular: 264.32

Ref: 86-MM3699.00

Vorinostat

CAS: 149647-78-9

Fórmula: C₁₄H₂₀N₂O₃

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 264.32

Ref: 7W-GP5178

Vorinostat-13C6

CAS: 149647-78-9

Fórmula: C₆C₈H₂₀N₂O₃

Peso molecular: 270.28

Ref: 4Z-V-079

Suberoylanilide Hydroxamic Acid

Producto controlado

CAS: 149647-78-9

Fórmula: C₁₄H₂₀N₂O₃

Forma y color: White Solid

Peso molecular: 264.32

Ref: TR-S688700

Vorinostat

CAS: 149647-78-9

M06303 - Vorinostat

Fórmula: C₁₄H₂₀N₂O₃

Pureza: 97%

Forma y color: Solid

Peso molecular: 264.325

Ref: 10-M06303

Vorinostat

CAS: 149647-78-9

Vorinostat is a histone deacetylase inhibitor which interferes with gene transcription regulatory mechanisms. It targets histones and non-histone proteins within transcription factor complexes involved in regulation of cell proliferation (p53), protein stability (Hsp90), apoptosis (Bcl-2 family), cell motility (α-tublin), and angiogenesis (HIF-1α). Vorinostat affects epigenetic regulation in various cancers and has been used in clinical trials as anticancer drug.

Fórmula: C₁₄H₂₀N₂O₃

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 264.32 g/mol

Ref: 3D-FH15949

Vorinostat - Bio-X ™

CAS: 149647-78-9

Vorinostat is a histone deacetylase inhibitor which interferes with gene transcription regulatory mechanisms. It is used to treat cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. This drug inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II).

Fórmula: C₁₄H₂₀N₂O₃

Pureza: Min. 99 Area-%

Forma y color: Powder

Peso molecular: 264.32 g/mol

Ref: 3D-BV164560

Suberoylanilide Hydroxamic Acid-13C6

Producto controlado

CAS: 149647-78-9

Applications is the labeled form of Suberoylanilide Hydroxamic Acid (S688700), which is a potent, selective, cell permeable histone deacetylase inhibitor (HDAC), displays anti-angiogenic activity by interfering with VEGF signaling in human umbilical vein endothelial cells (HUVECs) and induces differentiation in human breast cancer cells. Also it is a potent histone deacetylase inhibitor.
References Richon, V.M., et al.: Proc. Natl. Acad.Sci. USA, 95, 3003 (1988), Munster, P.N., et al.: Cancer Res., 61, 8492 (2001), Deroanne, C.F., et al.: Oncogene, 21, 247 (2002)

Fórmula: C₆C₈H₂₀N₂O₃

Forma y color: Neat

Peso molecular: 270.276

Ref: TR-S688704