CAS 152-58-9

11-Desoxicortisol

Descripción:

11-Desoxicortisol, también conocido como cortodoxona, es una hormona esteroide que desempeña un papel significativo en la biosíntesis de corticosteroides. Se clasifica como un glucocorticoide y se produce en la corteza adrenal. La estructura química de 11-Desoxicortisol presenta un esqueleto esteroide, caracterizado por cuatro anillos de carbono fusionados, con grupos funcionales específicos que contribuyen a su actividad biológica. Es un precursor en la síntesis de cortisol, que es crucial para regular el metabolismo, la respuesta inmune y la respuesta al estrés en el cuerpo. El número CAS 152-58-9 identifica de manera única este compuesto en bases de datos químicas. En términos de solubilidad, 11-Desoxicortisol es generalmente lipofílico, lo que le permite cruzar fácilmente las membranas celulares y ejercer sus efectos en los tejidos objetivo. Su actividad biológica se media a través de la unión a receptores de glucocorticoides, influyendo en la expresión génica y las funciones celulares. Debido a su papel en el sistema endocrino, las alteraciones en los niveles de 11-Desoxicortisol pueden ser indicativas de diversas condiciones de salud, incluida la insuficiencia adrenal o la hiperplasia.

Fórmula: C₂₁H₃₀O₄

InChI: InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1

Clave InChI: InChIKey=WHBHBVVOGNECLV-OBQKJFGGSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]

Sinónimos:

• (8R,10R,13S,17R)-17-Hydroxy-17-(2-hydroxy-acetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
• (8Xi,9Xi,10Xi,13Xi,14Xi)-17,21-Dihydroxypregn-4-Ene-3,20-Dione
• 11-Deoxy-17-hydrocorticosterone
• 11-Deoxy-17-hydroxycorticosterone
• 11-Deoxycortisol
• 11-Deoxycortisone
• 11-Deoxyhydrocortisone
• 11-Desoxy-17-hydroxycorticosterone
• 11-Desoxy-17α-hydroxycorticosterone
• 11-Desoxycortisol
• 11-Desoxycortisone
• 11-Desoxyhydrocortisone
• 11-Dioxycortisol
• 17,21-Dihydroxy-4-pregnene-3,20-dione
• 17,21-Dihydroxy-Pregn-4-Ene-3,20-Dione
• 17,21-Dihydroxypregn-4-en-3,20-dione
• 17,21-Dihydroxypregn-4-ene-3,20-dione
• 17,21-Dihydroxyprogesterone
• 17-Hydroxy-11-deoxycorticosterone
• 17alpha,21-Dihydroxypregn-4-ene-3,20-dione
• 17Α,21-Dihydroxypregn-4-Ene-3,20-Dione
• 17α,21-Dihydroxy-4-pregnen-3,20-dion
• 17α,21-Dihydroxy-4-pregnen-3,20-dione
• 17α,21-Dihydroxyprogesterone
• 17α-Hydroxycortexone
• 4-Pregnen-17α,21-diol-3,20-dion
• 4-Pregnen-17α,21-diol-3,20-dione
• 4-Pregnene-11β,17,21-triol-3,20-dione
• 4-Pregnene-17α, 21-diol-3,20-dione
• Compound S
• Corticosterone, 11-deoxy-17-hydroxy-
• Cortifen
• Cortisol, 11-deoxy-
• Cortisol, 11-dioxy-
• Cortodoxon
• Cortodoxona
• Cortodoxone
• Nsc 18317
• Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
• Reichstein S
• Reichstein substance S
• Reichstein's Substanz S
• Reichstein's compound S
• Reichstein's substance S
• Sk&F 3050
• Skf 3050
• Substance S
• cortodoxone (INN)
• Δ4-Pregnene-17α,21-diol-3,20-dione
• Δ⁴-Pregnene-17α,21-diol-3,20-dione

Cortexolone

CAS: 152-58-9

Fórmula: C₂₁H₃₀O₄

Pureza: >98.0%(HPLC)

Forma y color: White to Light yellow to Light orange powder to crystal

Peso molecular: 346.47

Ref: 3B-C1478

11-Deoxycortisol (17,21-Dihydroxypregn-4-ene-3,20-dione) 1.0 mg/ml in Methanol

CAS: 152-58-9

Forma y color: Single Solution

Ref: 61-AMP0185.08-01

11-Deoxycortisol, 1mg/ml in Acetonitrile

CAS: 152-58-9

Forma y color: Single Solution

Ref: LP-COR-1627-1LA

Cortodoxone (17,21-Dihydroxypregn-4-ene-3,20-dione)

CAS: 152-58-9

Adrenal cortical hormones and their derivatives nesoi

Fórmula: C₂₁H₃₀O₄

Forma y color: White Powder

Peso molecular: 346.21441

Ref: 45-1A11650

Cortodoxone

CAS: 152-58-9

Fórmula: C₂₁H₃₀O₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 346.4605

Ref: IN-DA003P2I

Cortexolone (Hydrocortisone EP Impurity F)

CAS: 152-58-9

Fórmula: C₂₁H₃₀O₄

Peso molecular: 346.47

Ref: 4Z-C-502001

Cortexolone

CAS: 152-58-9

Cortexolone

Pureza: 98%

Peso molecular: 346.47g/mol

Ref: 54-OR1029721

Cortodoxone

CAS: 152-58-9

Cortodoxone

Pureza: ≥98%

Peso molecular: 346.46g/mol

Ref: 54-BUP00016

Reichsteins substance S

CAS: 152-58-9

Fórmula: C₂₁H₃₀O₄

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 346.46

Ref: 7W-GK2007

17,21-Dihydroxypregn-4-ene-3,20-dione (Reichstein's Substance S)

Producto controlado

CAS: 152-58-9

Fórmula: C₂₁H₃₀O₄

Forma y color: Neat

Peso molecular: 346.46

Ref: 86-MM0185.08

11-Deoxycortisol

CAS: 152-58-9

Forma y color: Neat

Ref: LP-COR-1627-10

Cortodoxone

CAS: 152-58-9

Cortodoxone (11-Desoxycortisol) is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.

Fórmula: C₂₁H₃₀O₄

Pureza: 99.26% - 99.87%

Forma y color: Solid

Peso molecular: 346.46

Ref: TM-T2748

Cortexolone-d5 (Hydrocortisone EP Impurity F-d5)

CAS: 152-58-9

Fórmula: C₂₁H₂₅D₅O₄

Peso molecular: 351.50

Ref: 4Z-C-502002

Hydrocortisone EP Impurity F

CAS: 152-58-9

Fórmula: C₂₁H₃₀O₄

Peso molecular: 346.47

Ref: ST-EA-CP-H9006

11-Deoxy Cortisol-d7

Producto controlado

CAS: 152-58-9

Applications Glucocorticoid receptor binding.A representative lots showed approximately 10% d8.
References Gazdar, A., et al.: Cancer Res., 50, 5488, (1990), Bird, I., et al.: Endocrinology, 134, 2468 (1994), Auchus, R., et al.: J. Biol. Chem., 273, 3158 (1998), Dardis, A., et al.: J. Endocrinol., 179, 131 (2003),

Fórmula: C₂₁H₂₃D₇O₄

Forma y color: Neat

Peso molecular: 353.5

Ref: TR-D232602

11-Deoxy Cortisol

CAS: 152-58-9

Impurity Hydrocortisone EP Impurity F
Applications 11-Deoxy Cortisol (Hydrocortisone EP Impurity F) is a glucocorticoid receptor binding.
References Gazdar, A., et al.: Cancer Res., 50, 5488, (1990), Bird, I., et al.: Endocrinology, 134, 2468 (1994), Auchus, R., et al.: J. Biol. Chem., 273, 3158(1998), Dardis, A., et al.: J. Endocrinol., 179, 131 (2003),

Fórmula: C₂₁H₃₀O₄

Forma y color: Neat

Peso molecular: 346.46

Ref: TR-D232600

17,21-Dihydroxy-pregn-4-ene-3,20-dione

CAS: 152-58-9

Fórmula: C₂₁H₃₀O₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 346.467

Ref: 10-F242196

11-Deoxy-17-hydroxycorticosterone

Producto controlado

CAS: 152-58-9

11-Deoxycorticosterone (11DOC) is a naturally occurring corticosteroid that has been studied as a potential treatment for cancer. 11DOC is an antagonist of the mineralocorticoid receptor, which regulates sodium and potassium ions in the body. It also inhibits lymphocyte transformation and cell nuclei. The 11DOC-induced tumor regression was found to be due to decreased cortisol concentrations and increased corticosterone concentration in the experimental model. Increased corticosterone concentration led to cell lysis, while decreased cortisol concentration inhibited inflammatory lesion growth. Structural analysis revealed that 11DOC binds to the mineralocorticoid receptor with high affinity, but does not bind with high affinity to the glucocorticoid receptor. This suggests that 11DOC may be used for tumor treatment without negative side effects such as hair loss or increased appetite.

Fórmula: C₂₁H₃₀O₄

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 346.46 g/mol

Ref: 3D-FD21045

11-Deoxycortisol (17,21-Dihydroxypregn-4-ene-3,20-dione)

CAS: 152-58-9

Forma y color: Neat

Ref: 61-FOR0185.08