CAS 152-58-9

11-Desoxicortisol

Descripción:

11-Desoxicortisol, también conocido como cortodoxona, es una hormona esteroide que desempeña un papel significativo en la biosíntesis de corticosteroides. Se clasifica como un glucocorticoide y se produce en la corteza adrenal. La estructura química de 11-Desoxicortisol presenta un esqueleto esteroide, caracterizado por cuatro anillos de carbono fusionados, con grupos funcionales específicos que contribuyen a su actividad biológica. Es un precursor en la síntesis de cortisol, que es crucial para regular el metabolismo, la respuesta inmune y la respuesta al estrés en el cuerpo. El número CAS 152-58-9 identifica de manera única este compuesto en bases de datos químicas. En términos de solubilidad, 11-Desoxicortisol es generalmente lipofílico, lo que le permite cruzar fácilmente las membranas celulares y ejercer sus efectos en los tejidos objetivo. Su actividad biológica se media a través de la unión a receptores de glucocorticoides, influyendo en la expresión génica y las funciones celulares. Debido a su papel en el sistema endocrino, las alteraciones en los niveles de 11-Desoxicortisol pueden ser indicativas de diversas condiciones de salud, incluida la insuficiencia adrenal o la hiperplasia.

Fórmula: C₂₁H₃₀O₄

InChI: InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1

Clave InChI: InChIKey=WHBHBVVOGNECLV-OBQKJFGGSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]

Sinónimos:

• (8R,10R,13S,17R)-17-Hydroxy-17-(2-hydroxy-acetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
• (8Xi,9Xi,10Xi,13Xi,14Xi)-17,21-Dihydroxypregn-4-Ene-3,20-Dione
• 11-Deoxy-17-hydrocorticosterone
• 11-Deoxy-17-hydroxycorticosterone
• 11-Deoxycortisol
• 11-Deoxycortisone
• 11-Deoxyhydrocortisone
• 11-Desoxy-17-hydroxycorticosterone
• 11-Desoxy-17α-hydroxycorticosterone
• 11-Desoxycortisol
• 11-Desoxycortisone
• 11-Desoxyhydrocortisone
• 11-Dioxycortisol
• 17,21-Dihydroxy-4-pregnene-3,20-dione
• 17,21-Dihydroxy-Pregn-4-Ene-3,20-Dione
• 17,21-Dihydroxypregn-4-en-3,20-dione
• 17,21-Dihydroxypregn-4-ene-3,20-dione
• 17,21-Dihydroxyprogesterone
• 17-Hydroxy-11-deoxycorticosterone
• 17alpha,21-Dihydroxypregn-4-ene-3,20-dione
• 17Α,21-Dihydroxypregn-4-Ene-3,20-Dione
• 17α,21-Dihydroxy-4-pregnen-3,20-dion
• 17α,21-Dihydroxy-4-pregnen-3,20-dione
• 17α,21-Dihydroxyprogesterone
• 17α-Hydroxycortexone
• 4-Pregnen-17α,21-diol-3,20-dion
• 4-Pregnen-17α,21-diol-3,20-dione
• 4-Pregnene-11β,17,21-triol-3,20-dione
• 4-Pregnene-17α, 21-diol-3,20-dione
• Compound S
• Corticosterone, 11-deoxy-17-hydroxy-
• Cortifen
• Cortisol, 11-deoxy-
• Cortisol, 11-dioxy-
• Cortodoxon
• Cortodoxona
• Cortodoxone
• Nsc 18317
• Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
• Reichstein S
• Reichstein substance S
• Reichstein's Substanz S
• Reichstein's compound S
• Reichstein's substance S
• Sk&F 3050
• Skf 3050
• Substance S
• cortodoxone (INN)
• Δ4-Pregnene-17α,21-diol-3,20-dione
• Δ⁴-Pregnene-17α,21-diol-3,20-dione

11-Deoxycortisol in Methanol

CAS: 152-58-9

Methanol

Ref: BE-MU-2085XM-100

17,21-Dihydroxy-pregn-4-ene-3,20-dione

CAS: 152-58-9

Fórmula: C₂₁H₃₀O₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 346.467

Ref: 10-F242196

11-Deoxy-17-hydroxycorticosterone

Producto controlado

CAS: 152-58-9

11-Deoxycorticosterone (11DOC) is a naturally occurring corticosteroid that has been studied as a potential treatment for cancer. 11DOC is an antagonist of the mineralocorticoid receptor, which regulates sodium and potassium ions in the body. It also inhibits lymphocyte transformation and cell nuclei. The 11DOC-induced tumor regression was found to be due to decreased cortisol concentrations and increased corticosterone concentration in the experimental model. Increased corticosterone concentration led to cell lysis, while decreased cortisol concentration inhibited inflammatory lesion growth. Structural analysis revealed that 11DOC binds to the mineralocorticoid receptor with high affinity, but does not bind with high affinity to the glucocorticoid receptor. This suggests that 11DOC may be used for tumor treatment without negative side effects such as hair loss or increased appetite.

Fórmula: C₂₁H₃₀O₄

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 346.46 g/mol

Ref: 3D-FD21045