CAS 15291-75-5

Ginkgólido A

Descripción:

Ginkgólido A es un compuesto natural derivado de las hojas del árbol Ginkgo biloba, conocido por sus posibles beneficios para la salud y propiedades medicinales. Pertenece a una clase de compuestos llamados terpenoides, específicamente un tipo de lactona diterpénica. Ginkgólido A se caracteriza por su estructura bicíclica única, que contribuye a su actividad biológica. Exhibe varios efectos farmacológicos, incluyendo propiedades neuroprotectoras, antiinflamatorias y antioxidantes, lo que lo hace de interés en el estudio de enfermedades neurodegenerativas y mejora cognitiva. Además, se ha investigado Ginkgólido A por su capacidad para inhibir el factor activador de plaquetas (PAF), que juega un papel en la inflamación y la trombosis. El compuesto se encuentra típicamente en suplementos herbales y extractos derivados de Ginkgo biloba, y su perfil de seguridad ha sido evaluado en varios estudios. Sin embargo, al igual que muchos productos herbales, puede interactuar con otros medicamentos, por lo que se aconseja precaución cuando se utiliza junto con anticoagulantes o medicamentos antiplaquetarios. En general, Ginkgólido A representa un área significativa de investigación en fitoquímica y farmacología.

Fórmula: C₂₀H₂₄O₉

InChI: InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18?,19-,20?/m1/s1

Clave InChI: InChIKey=FPUXKXIZEIDQKW-IKIFPUOBSA-N

SMILES: O[C@@]12C34[C@]5(C6([C@](O3)(OC(=O)[C@@H]6O)[H])[C@H](C(C)(C)C)C[C@]5(OC4=O)[H])C[C@@]1(OC(=O)[C@H]2C)[H]

Sinónimos:

• (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
• (1R,3aR,4bR,5S,7aS,9R,11S)-11-tert-butyl-1,4b-dihydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H,5H)-trione
• (3aR,4aR,4bR,5S,7aS,9R,11S)-11-tert-butyl-1,4b-dihydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H,5H)-trione
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R-(1alpha,3beta,3aS*,4beta,6aalpha,7aalpha,7balpha,8alpha,10aalpha,11 aS*))-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-tert-butylhexahydro-4,7b-dihydroxy-8-methyl-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11aS*)]-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-tert-butylhexahydro-4,7b-dihydroxy-8-methyl-
• Bilobalide A
• Bn 52020
• [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11aS*)]-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione

Ginkgolide A

CAS: 15291-75-5

Fórmula: C₂₀H₂₄O₉

Pureza: >98.0%(HPLC)(qNMR)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 408.40

Ref: 3B-G0521

Ginkgolide A

CAS: 15291-75-5

Platelet-Activating Factor (PAF) antagonist

Fórmula: C₂₀H₂₄O₉

Peso molecular: 408.41

Ref: 02-J62384

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₂₀H₂₄O₉

Pureza: (HPLC) ≥98%

Forma y color: Powder

Peso molecular: 408.41

Ref: 11-3728S

Ginkgolide A

CAS: 15291-75-5

Fórmula: C₂₀H₂₄O₉

Pureza: 98%

Forma y color: Solid

Peso molecular: 408.3992

Ref: IN-DA003839

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A

Pureza: 97%

Peso molecular: 408.4g/mol

Ref: 54-OR1024130

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A

Pureza: ≥98%

Peso molecular: 408.4g/mol

Ref: 54-BUP06903

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A is a platelet-activating factor antagonist, it can inhibit the neurotoxicity of prions or amyloid-beta1-42, may be relevant treatments for prion or Alzheimer's diseases.Ginkgolide A has neuroprotective, and anxiolytic-like effects, it is widely used for the treatment of cardiovascular diseases and diabetic vascular complications, which might be achieved through regulating the STAT3-mediated pathway.

Fórmula: C₂₀H₂₄O₉

Pureza: 95%~99%

Peso molecular: 408.403

Ref: BP-BP0646

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A (BN-52020), from Ginkgo biloba leaves, is an active PAF antagonist with potential in treating inflammation and immune disorders.

Fórmula: C₂₀H₂₄O₉

Pureza: 98.76% - 99.81%

Forma y color: White Powder

Peso molecular: 408.4

Ref: TM-T2749

Ginkgolide A

CAS: 15291-75-5

Fórmula: C₂₀H₂₄O₉

Peso molecular: 408.40

Ref: 4Z-G-176003

Ginkgolide A

CAS: 15291-75-5

Fórmula: C₂₀H₂₄O₉

Pureza: (HPLC) ≥ 98.0%

Forma y color: Off-white powder

Peso molecular: 408.41

Ref: 7W-GP9109

Ginkgolide a

CAS: 15291-75-5

Lactone

Fórmula: C₂₀H₂₄O₉

Pureza: ≥ 95.0 % (HPLC)

Forma y color: Powder

Peso molecular: 408.41

Ref: 5G-89204

Ginkgolide A

Producto controlado

CAS: 15291-75-5

Applications Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists.
References Korth, R., et al.: Eur. J. Pharmacol., 152, 101 (1988), Braquet, P., et al.: Med. Res. Rev., 11, 295 (1991), van Beek, T.A., et al.: Bioorg. Med. Chem., 13, 5001 (2005)

Fórmula: C₂₀H₂₄O₉

Forma y color: Neat

Peso molecular: 408.40

Ref: TR-G387425

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A is a terpenoid lactone, which is a diterpene known for its presence in the leaves of the Ginkgo biloba tree. As a bioactive compound, it is naturally sourced from this ancient plant, which has been utilized in traditional medicine for centuries. Ginkgolide A acts primarily as an antagonist of platelet-activating factor (PAF), thereby influencing a range of physiological processes. Its modulatory effects on neurotransmission and vascular function arise from its ability to inhibit PAF binding to its receptor, reducing platelet aggregation and improving microcirculatory flow.

Fórmula: C₂₀H₂₄O₉

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 408.4 g/mol

Ref: 3D-FG10335

Ginkgolide Impurity A

CAS: 15291-75-5

Fórmula: C₂₀H₂₄O₉

Peso molecular: 408.40

Ref: ST-EA-CP-G15001