CAS 15291-77-7

Ginkgólido B

Descripción:

Ginkgólido B es un compuesto natural derivado de las hojas del árbol Ginkgo biloba, conocido por sus posibles propiedades terapéuticas. Pertenece a una clase de compuestos llamados terpenoides, específicamente un tipo de ginkgolido, que son únicos de las especies de Ginkgo. Ginkgólido B se caracteriza por su compleja estructura bicíclica, que contribuye a su actividad biológica. Exhibe varios efectos farmacológicos, incluyendo propiedades neuroprotectoras, antiinflamatorias y antioxidantes, lo que lo hace de interés en el estudio de enfermedades neurodegenerativas y mejora cognitiva. Además, se ha investigado Ginkgólido B por su capacidad para inhibir el factor activador de plaquetas (PAF), que juega un papel en la inflamación y la trombosis. El compuesto se estudia típicamente en el contexto de la medicina herbal y los suplementos dietéticos, a menudo comercializados para mejorar la memoria y la circulación. Sin embargo, su eficacia y perfil de seguridad requieren más investigación para comprender completamente sus posibles beneficios y riesgos en aplicaciones clínicas.

Fórmula: C₂₀H₂₄O₁₀

InChI: InChI=1/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9-,10+,11+,15+,17?,18?,19-,20-/m1/s1

Clave InChI: InChIKey=SQOJOAFXDQDRGF-MAGGBRLHSA-N

SMILES: O[C@@H]1C23C4([C@]5(O)[C@]1(OC(=O)[C@H]5C)[H])O[C@]6(C2([C@H](C(C)(C)C)C[C@]3(OC4=O)[H])[C@@H](O)C(=O)O6)[H]

Sinónimos:

• (1R,3R,6R,8S,10R,12S,13S,16S,17R)-6,12,17-Trihydroxy-16-methyl-8-(2-methyl-2-propanyl)-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecan-5,15,18-trion
• (1R,3R,6R,8S,10R,12S,13S,16S,17R)-6,12,17-Trihydroxy-16-methyl-8-(2-methyl-2-propanyl)-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione
• (1R,3R,6R,8S,10R,12S,13S,16S,17R)-8-tert-Butyl-6,12,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione
• (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
• (1R,3aR,4aR,4bR,5S,7aS,8S,9R,11S)-11-tert-butyl-1,4b,8-trihydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H,5H)-trione
• (1b)-1-Hydroxyginkgolide A
• 5H-Dicyclopenta[b,c]furan-3,5a(6H)-diacetic acid, 6-tert-butyl-3a-carboxyhexahydro-α^5a,1,2,3,5,8-hexahydroxy-α³-methyl-, tri-γ-lactone
• 6H-9,4a-(epoxymethano)-3aH,9H-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H)-trione, 11-(1,1-dimethylethyl)hexahydro-1,4b,8-trihydroxy-5-methyl-, (1R,3aR,4aR,4bR,5S,7aS,8S,9R,11S)-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-, [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11β,11aR*)]-
• Bilobalide B
• Bn 52021
• Bn 52051
• Ginkgolide A, 1-hydroxy-, (1β)-
• Ginkgolide B
• Ginkgolides, ginkgolide B
• 5H-Dicyclopenta[b,c]furan-3,5a(6H)-diacetic acid, 6-tert-butyl-3a-carboxyhexahydro-α5a,1,2,3,5,8-hexahydroxy-α3-methyl-, tri-γ-lactone
• (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
• ginkgolide B from ginkgo leaves
• ginkgolide b from ginkgo biloba leaves
• 7-DEOXYGINKGOLIDE C

Ginkgolide B

CAS: 15291-77-7

Fórmula: C₂₀H₂₄O₁₀

Pureza: >93.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 424.40

Ref: 3B-G0553

Ginkgolide B

CAS: 15291-77-7

Platelet-Activating Factor (PAF) antagonist

Fórmula: C₂₀H₂₄O₁₀

Peso molecular: 424.4

Ref: 02-J60646

Ginkgolide B

CAS: 15291-77-7

Ginkgolide B analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₂₀H₂₄O₁₀

Pureza: (HPLC) ≥98%

Forma y color: Powder

Peso molecular: 424.41

Ref: 11-3729S

Ginkgolide B

CAS: 15291-77-7

Ginkgolide B

Pureza: ≥98%

Peso molecular: 424.4g/mol

Ref: 54-BUP11715

Ginkgolide B

CAS: 15291-77-7

Ginkgolide B has potent neuroprotective, anti-arrhythmias, anti-inflammatory and anti-apoptotic effects, it might be a promising drug on inhibiting platelet function and reducing inflammation in atherosclerosis.Ginkgolide B retards the proliferation and development of mouse embryonic stem cells (ESCs) and blastocysts in vitro and causes developmental injury in vivo.

Fórmula: C₂₀H₂₄O₁₀

Pureza: 95%~99%

Peso molecular: 424.402

Ref: BP-BP0647

Ginkgolide B

CAS: 15291-77-7

Fórmula: C₂₀H₂₄O₁₀

Peso molecular: 424.40

Ref: 7W-GP5638

Ginkgolide B

CAS: 15291-77-7

Fórmula: C₂₀H₂₄O₁₀

Peso molecular: 424.40

Ref: 4Z-G-176004

Ginkgolide B

CAS: 15291-77-7

Ginkgolide B (BN-52021) is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.

Fórmula: C₂₀H₂₄O₁₀

Pureza: 98.66% - 99.81%

Forma y color: White Crystal Powder

Peso molecular: 424.4

Ref: TM-T2751

Ginkgolide b

CAS: 15291-77-7

Lactone

Fórmula: C₂₀H₂₄O₁₀

Pureza: ≥ 98.0 % (HPLC)

Forma y color: Powder

Peso molecular: 424.41

Ref: 5G-89205

Ginkgolide B

CAS: 15291-77-7

Applications Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists.
References Korth, R., et al.: Eur. J. Pharmacol., 152, 101 (1988), Braquet, P., et al.: Med. Res. Rev., 11, 295 (1991), van Beek, T.A., et al.: Bioorg. Med. Chem., 13, 5001 (2005)

Fórmula: C₂₀H₂₄O₁₀

Forma y color: Neat

Peso molecular: 424.40

Ref: TR-G387430

Ginkgolide B

CAS: 15291-77-7

Ginkgolide B is a diterpenoid lactone, which is a secondary metabolite isolated from the leaves of the Ginkgo biloba tree. This compound is primarily sourced from the extract of Ginkgo biloba, a plant that has been utilized for centuries in traditional medicine systems.

Fórmula: C₂₀H₂₄O₁₀

Pureza: Min. 90 Area-%

Forma y color: White Powder

Peso molecular: 424.4 g/mol

Ref: 3D-FG10334

Ginkgolide Impurity B

CAS: 15291-77-7

Fórmula: C₂₀H₂₄O₁₀

Peso molecular: 424.40

Ref: ST-EA-CP-G15002