CAS 153-61-7

Cefalotina

Descripción:

Cefalotina es un antibiótico semisintético que pertenece a la clase de las cefalosporinas, utilizado principalmente por sus propiedades antibacterianas. Es efectivo contra una variedad de bacterias Gram-positivas y algunas Gram-negativas, lo que lo hace útil en el tratamiento de diversas infecciones. El compuesto se caracteriza por su estructura de beta-lactama, que es esencial para su mecanismo de acción, ya que inhibe la síntesis de la pared celular bacteriana. Cefalotina se administra típicamente por inyección y es conocido por su estabilidad contra ciertos beta-lactamasas, aunque no es resistente a todos los tipos. Su farmacocinética implica una rápida absorción y distribución en el cuerpo, con una vida media relativamente corta, lo que requiere múltiples dosis para un tratamiento efectivo. Los efectos secundarios comunes pueden incluir reacciones alérgicas, trastornos gastrointestinales y posibles impactos en la función renal. Al igual que con otros antibióticos, la aparición de resistencia es una preocupación, lo que resalta la importancia de un uso apropiado en entornos clínicos. En general, Cefalotina sigue siendo una opción valiosa en el arsenal de antibióticos, particularmente para infecciones causadas por organismos susceptibles.

Fórmula: C₁₆H₁₆N₂O₆S₂

InChI: InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1

Clave InChI: InChIKey=XIURVHNZVLADCM-IUODEOHRSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(CC3=CC=CS3)=O)C2=O)(SCC1COC(C)=O)[H]

Sinónimos:

• (6R,7R)-3-(Acetoxymethyl)-8-Oxo-7-(2-(Thiophen-2-Yl)Acetamido)-5-Thia-1-Aza-Bicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
• (6R,7R)-3-[(Acetyloxy)methyl]-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R-trans)-3-[(Acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6S,7S)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 3-(Acetoxymethyl)-8-oxo-7-[2-(2-thienyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid
• 5-Thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-[2-(2-thienyl)acetamido]-, acetate (ester)
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-, (6R-trans)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-, (6R,7R)-
• 7-(2-Thienylacetamido)cephalosporanic acid
• 7-(Thiophene-2-acetamido)cephalosporin
• 7-[2-(2-Thienyl)acetylamido]cephalosporanic acid
• CT
• Cefalothin
• Cefalothin Acid
• Cefalotin
• Cefalotin Acid
• Cefalotina
• Cefalotine
• Cephalotin
• Cephalotin acid
• Ceratinine, standard solution
• Fatty acids, tall-oil, sulfonated

Cephalothin

CAS: 153-61-7

Fórmula: C₁₆H₁₆N₂O₆S₂

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Orange to Green powder to crystal

Peso molecular: 396.43

Ref: 3B-C2769

Cephalothin (acid), 97%

CAS: 153-61-7

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Fórmula: C₁₆H₁₅N₂NaO₆S₂

Pureza: 97%

Forma y color: Powder, White to pale cream

Peso molecular: 418.41

Ref: 02-H36175

(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS: 153-61-7

Fórmula: C₁₆H₁₆N₂O₆S₂

Pureza: 97%

Forma y color: Solid

Peso molecular: 396.4380

Ref: IN-DA007HPY

Cephalothin

CAS: 153-61-7

Cephalothin

Pureza: ≥98%

Peso molecular: 396.44g/mol

Ref: 54-BUP13813

Cefalotin

CAS: 153-61-7

Cefalotin

Pureza: 97%

Peso molecular: 396.44g/mol

Ref: 54-OR1030085

Cefalotin

CAS: 153-61-7

Fórmula: C₁₆H₁₆N₂O₆S₂

Pureza: ≥ 97.0%

Forma y color: White to off-white powder

Peso molecular: 396.44

Ref: 7W-GA3485

Cefalotin

Producto controlado

CAS: 153-61-7

Fórmula: C₁₆H₁₆N₂O₆S₂

Forma y color: Neat

Peso molecular: 396.44

Ref: 04-C11064065

Cefalonium Impurity A (Cefalotin)

CAS: 153-61-7

Fórmula: C₁₆H₁₆N₂O₆S₂

Peso molecular: 396.44

Ref: 4Z-C-229002

Cephalothin

CAS: 153-61-7

Cephalothin is a beta-lactam antibiotic, inhibits class C β-lactamase AmpC (Ki: 0.32 μM).

Fórmula: C₁₆H₁₆N₂O₆S₂

Pureza: 99.62%

Forma y color: Solid Solid

Peso molecular: 396.44

Ref: TM-T5570

Cephalothin

Producto controlado

CAS: 153-61-7

Applications A first generation cephalosporin antibiotic with a wide range antibacterial activity. It is effective against gram-positive and gram-negative bacteria, and has been tested in respiratory disease and neuromuscular junction studies.
References Shibata, K., et al.: J. Antibiot., 50, 135 (1997); Farra, A., et al.: Int. J. Antimicrob. Agents., 31, 427 (2008); Pichardo, C., et al.: Eur. J. Clin. Microbiol. Infect. Dis., 30, 289 (2011);

Fórmula: C₁₆H₁₆N₂O₆S₂

Forma y color: Neat

Peso molecular: 396.44

Ref: TR-C261150

(6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS: 153-61-7

Fórmula: C₁₆H₁₆N₂O₆S₂

Pureza: 97%

Forma y color: White powder

Peso molecular: 396.43

Ref: 10-F079464

(6R,7R)-3-((4-Carbamoylpyridin-1-ium-1-yl)methyl)-7-((R)-2-hydroxy-2-(thiophen-2-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Producto controlado

CAS: 153-61-7

Fórmula: C₂₀H₁₈N₄O₆S₂

Forma y color: Neat

Peso molecular: 474.51

Ref: TR-C261180

(6R,7R)-3-((4-Carbamoylpyridin-1-ium-1-yl)methyl)-7-((S)-2-hydroxy-2-(thiophen-2-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Producto controlado

CAS: 153-61-7

Fórmula: C₂₀H₁₈N₄O₆S₂

Forma y color: Neat

Peso molecular: 474.51

Ref: TR-C261170

(6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS: 153-61-7

(6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is an antimicrobial agent that inhibits bacterial growth by binding to the penicillin binding protein (PBP), which prevents the synthesis of peptidoglycan. This drug has shown effectiveness against gram positive bacteria, including aerobacter aerogenes, as well as infectious diseases in wastewater treatment plants. It has also been demonstrated to be effective in experimental models of infection due to high resistance and cell signaling pathways. The reaction solution was analyzed by plasma mass spectrometry.

Fórmula: C₁₆H₁₆N₂O₆S₂

Pureza: Min. 98%

Forma y color: White Powder

Peso molecular: 396.44 g/mol

Ref: 3D-FA32097