CAS 154598-52-4
:Efavirenz
Descripción:
Efavirenz es un inhibidor de la transcriptasa inversa no nucleósido (INNTI) utilizado principalmente en el tratamiento de la infección por VIH. Se caracteriza por su capacidad para inhibir la enzima transcriptasa inversa, que es crucial para la replicación del virus VIH. Químicamente, Efavirenz es un compuesto lipofílico, lo que contribuye a sus propiedades farmacocinéticas, incluyendo una larga vida media y la capacidad de penetrar en el sistema nervioso central. La sustancia se administra típicamente por vía oral y a menudo es parte de la terapia combinada para mejorar la eficacia y reducir el riesgo de resistencia. Efavirenz es conocido por sus efectos secundarios, que pueden incluir síntomas neuropsiquiátricos, erupciones cutáneas y posibles efectos sobre la función hepática. Su mecanismo de acción implica la unión a la enzima transcriptasa inversa, lo que lleva a la interrupción de la conversión del ARN viral a ADN. El compuesto está clasificado en la Lista de Medicamentos Esenciales de la Organización Mundial de la Salud, lo que destaca su importancia en la salud global. Al igual que con cualquier medicamento, es esencial monitorear los efectos adversos y las interacciones medicamentosas durante el tratamiento.
Fórmula:C14H9ClF3NO2
InChI:InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1
Clave InChI:InChIKey=XPOQHMRABVBWPR-ZDUSSCGKSA-N
SMILES:C(#CC1CC1)[C@@]2(C(F)(F)F)C=3C(NC(=O)O2)=CC=C(Cl)C3
Sinónimos:- (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (4S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
- (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
- (S)-4-(2-Cyclopropylethynyl)-6-chloro-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
- (S)-4-(Cyclopropylethynyl)-6-chloro-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
- (S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (S)-Efavirenz
- 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-
- 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-
- 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (S)-
- Dmp 266
- Efavuirenz
- L 743726
- Stocrin
- Ver más sinónimos
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Encontrado 18 productos.
Efavirenz
CAS:Fórmula:C14H9ClF3NO2Pureza:>98.0%(HPLC)(N)Forma y color:White to Almost white powder to crystalPeso molecular:315.68Efavirenz
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C14H9ClF3NO2Forma y color:White Off-White Yellow Pink Crystalline PowderPeso molecular:315.67 g/mol(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one
CAS:Fórmula:C14H9ClF3NO2Pureza:98%Forma y color:SolidPeso molecular:315.6750Efavirenz
CAS:Fórmula:C14H9ClF3NO2Pureza:≥ 98.0%Forma y color:White to off-white crystalline powderPeso molecular:315.68Efavirenz
CAS:Efavirenz (DMP 266) is an HIV-1 inhibitor, affecting reverse transcriptase and various cytochrome P450 enzymes.Fórmula:C14H9ClF3NO2Pureza:99.2% - 99.84%Forma y color:White To Slightly Pink Crystalline PowderPeso molecular:315.67(S)-Efavirenz
CAS:<p>Applications A nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>Fórmula:C14H9ClF3NO2Forma y color:NeatPeso molecular:315.68Efavirenz
CAS:Efavirenz is a non-nucleoside-based reverse transcriptase inhibitor (NNRTI) of the reverse transcriptase of HIV-1. It inhibits the viral enzyme reverse transcriptase by binding to its active site. In certain cell culture assays, efavirenz showed great efficiency when inhibiting wild-type HIV-1 replication with values of inhibition constant Ki between 2.97 to 17.60 mM in single mutation enzymes and 26.05 to 56.50 nM in double mutation. In the treatment of HIV, efavirenz has been studied in combination with emtricitabine and tenofovir disoproxil fumarate for ease of administration in some clinical studies. Recent in vitro cell studies indicated efavirenz is a potential treatment for pancreatic, prostate and triple-negative breast cancers due to its cytotoxicity against cancer cells, with an EC50 of 31.5 μM.Fórmula:C14H9ClF3NO2Pureza:Min. 95%Forma y color:PowderPeso molecular:315.68 g/molEfavirenz - Bio-X ™
CAS:<p>Efavirenz is a non-nucleoside-based reverse transcriptase inhibitor (NNRTI) of the reverse transcriptase of HIV-1. It inhibits the viral enzyme reverse transcriptase by binding to its active site. In certain cell culture assays, Efavirenz showed great efficiency when inhibiting wild-type HIV-1 replication. In the treatment of HIV, Efavirenz has been studied in combination with Emtricitabine and Tenofovir disoproxil fumarate for ease of administration in some clinical studies. Recent in vitro cell studies indicated Efavirenz is a potential treatment for pancreatic, prostate and triple-negative breast cancers due to its cytotoxicity against cancer cells.Efavirenz is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Fórmula:C14H9ClF3NO2Pureza:Min. 95%Forma y color:PowderPeso molecular:315.67 g/mol(4S)-6-CHLORO-4-(CYCLOPROPYLETHYNYL)-1,4-DIHYDRO-4-(TRIFLUOROMETHYL)-2H-3,1-BENZOXAZIN-2-ONE
CAS:Pureza:98%Peso molecular:315.6799927rac Efavirenz-8-d1
CAS:Producto controladoFórmula:C14DH8ClF3NO2Forma y color:NeatPeso molecular:316.681(S)-7,14-Dihydroxy Efavirenz
CAS:Producto controladoFórmula:C14H9ClF3NO4Forma y color:NeatPeso molecular:347.674
