CAS 154947-66-7
:LL-37
Descripción:
LL-37 es un péptido antimicrobiano catelicidina humano (CAMP) que desempeña un papel crucial en la respuesta inmune innata. Está compuesto por 37 aminoácidos y es conocido por su actividad antimicrobiana de amplio espectro contra varios patógenos, incluidos bacterias, hongos y virus. LL-37 exhibe una estructura anfipática única, lo que le permite interactuar y desestabilizar las membranas microbianas, llevando a la lisis celular. Además, posee propiedades inmunomoduladoras, influyendo en la inflamación y los procesos de cicatrización de heridas. LL-37 es producido por varias células, incluidas los neutrófilos y las células epiteliales, y se encuentra en varios tejidos, particularmente durante infecciones o lesiones. Su capacidad para promover la angiogénesis y modular las respuestas inmunitarias lo convierte en un tema de interés en la investigación terapéutica, particularmente en el contexto de heridas crónicas e infecciones. En general, LL-37 es un componente vital del sistema de defensa del huésped, contribuyendo al mantenimiento de la integridad de la piel y las mucosas.
- H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
- antibacterial protein LL-37 amide
- LL-37(human)
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Encontrado 5 productos.
LL-37
CAS:LL-37 is an antimicrobial peptide with angiogenic activity. It corresponds to the C-terminal sequence (134-170) of the human cathelicidin antimicrobial protein hCAP18/LL-37 and is extracellularly released from hCAP18/LL-37 by proteolytic processing. hCAP18/LL-37 is an effector of the innate immune system and is expressed in leukocytes and epithelial cells where it is upregulated in association with inflammation and injury. An overexpression of hCAP18/LL-37 in a series of breast carcinomas could be demonstrated. LL-37 has been suggested to stimulate epithelial cell proliferation partially through formyl peptide receptor-like 1 (FPRL1) since blocking the receptor with pertussis toxin decreased the proliferative effect of LL-37 by approximately 50 %.Fórmula:C205H340N60O53Pureza:96.7%Forma y color:WhitePeso molecular:4493.33LL-37, Human
CAS:LL-37, Human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.Fórmula:C205H340N60O53Pureza:98%Forma y color:SolidPeso molecular:4493.26LL-37 ( Human)
CAS:<p>LL-37 is a 37 amino acid peptide that is produced by neutrophils and other leukocytes. This peptide has been shown to have anti-inflammatory properties, which may be due to its ability to bind and activate the G protein coupled receptor (GPCR) formyl peptide receptor-like 1 (FPRL1), leading to inhibition of the production of inflammatory mediators such as IL-8. LL-37 also binds to ion channels, which may lead to membrane depolarization, thereby blocking calcium influx into the cell. LL-37 has been shown to inhibit the activation of T cells by inhibiting T cell receptor signaling and reducing cytokine production.<br>LL-37 also has a high affinity for antibody binding sites on B cells and macrophages and can bind with high specificity to IgE on mast cells, leading to inhibition of mast cell degranulation. The binding of LL-37 with these receptors leads to reduced inflammation in tissues, which may</p>Fórmula:C205H340N60O53Pureza:Min. 95%Peso molecular:4,493.3 g/molCathelicidin LL 37
CAS:<p>LL-37 is a potent antimicrobial peptide that has been shown to be effective against cancer cells and is currently being investigated as a potential antineoplastic agent. LL-37 binds to the leukocyte receptor, which leads to chemotaxis, increased expression of p53 and apoptosis. LL-37 also induces apoptotic cell death in epithelial tissues, both in vitro and in vivo. This peptide has been shown to induce death in cancer cells, as well as cell death in other types of cells.</p>Fórmula:C205H340N60O53Pureza:Min. 95%Peso molecular:4,493.27 g/mol
