CAS 158584-08-8

7-metoxicumarina-4-acetil-arg-pro-*lis-pro-tir-A

Descripción:

7-metoxicumarina-4-acetil-arg-pro-*lis-pro-tir-A, identificado por su número CAS 158584-08-8, es un compuesto sintético que pertenece a la clase de los derivados de cumarina. Las cumarinas son conocidas por sus diversas actividades biológicas, incluyendo propiedades anticoagulantes, antiinflamatorias y antimicrobianas. Este compuesto en particular presenta un grupo metoxi y un moiety acetilo, que pueden influir en su solubilidad y reactividad. La presencia de la secuencia peptídica, que incluye aminoácidos como arginina, prolina, lisina y tirosina, sugiere una posible bioactividad relacionada con interacciones peptídicas y vías de señalización. Las modificaciones estructurales pueden mejorar su perfil farmacológico, convirtiéndolo en un candidato para diversas aplicaciones en química medicinal y desarrollo de fármacos. Además, la estabilidad, solubilidad e interacción del compuesto con objetivos biológicos serían factores críticos para determinar su eficacia y seguridad en contextos terapéuticos potenciales. Se necesitarían más estudios para elucidar sus mecanismos específicos de acción y posibles usos en entornos de investigación o clínicos.

Fórmula: C₇₉H₁₀₅N₁₉O₁₉S

InChI: InChI=1/C79H105N19O19S/c1-5-15-57(71(104)93-62(39-48-44-86-54-17-7-6-16-52(48)54)74(107)91-58(31-37-118-4)72(105)89-56(69(81)102)18-9-11-33-84-55-30-25-49(97(112)113)42-65(55)98(114)115)90-70(103)45(2)87-73(106)61(38-46-23-26-50(99)27-24-46)94-76(109)64-22-14-36-96(64)78(111)60(19-8-10-32-80)92-75(108)63-21-13-35-95(63)77(110)59(20-12-34-85-79(82)83)88-67(100)40-47-41-68(101)117-66-43-51(116-3)28-29-53(47)66/h6-7,16-17,23-30,41-45,56-64,84,86,99H,5,8-15,18-22,31-40,80H2,1-4H3,(H2,81,102)(H,87,106)(H,88,100)(H,89,105)(H,90,103)(H,91,107)(H,92,108)(H,93,104)(H,94,109)(H4,82,83,85)/t45-,56-,57-,58-,59-,60?,61-,62-,63-,64-/m0/s1

SMILES: CCC[C@@H](C(=N[C@@H](Cc1c[nH]c2ccccc12)C(=N[C@@H](CCSC)C(=N[C@@H](CCCCNc1ccc(cc1N(=O)=O)N(=O)=O)C(=N)O)O)O)O)N=C([C@H](C)N=C([C@H](Cc1ccc(cc1)O)N=C([C@@H]1CCCN1C(=O)C(CCCCN)N=C([C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N=C(Cc1cc(=O)oc2cc(ccc12)OC)O)O)O)O)O

Sinónimos:

• Nff 2
• (7-Methoxycoumarin-4-yl)acetyl-arginyl-prolyl-lysyl-prolyl-tyrosyl-alanyl-norvalyl-tryptophyl-methionyl-(2,4-dinitrophenyl)lysinamide
• Mca-arg-pro-lys-pro-tyr-ala-nva-trp-met-lys(dnp)-NH2
• N2-((7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl)-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-tyrosyl-L-alanyl-L-norvalyl-L-tryptophyl-L-methionyl-N6-(2,4-dinitrophenyl)-L-lysinamide
• L-Lysinamide, N2-((7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl)-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-tyrosyl-L-alanyl-L-norvalyl-L-tryptophyl-L-methionyl-N6-(2,4-dinitrophenyl)-
• L-Lysinamide, N2-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-tyrosyl-L-alanyl-L-norvalyl-L-tryptophyl-L-methionyl-N6-(2,4-dinitrophenyl)-
• (7-METHOXYCOUMARIN-4-YL)ACETYL-L-ARGINYL-L-PROLYL-L-LYSYL-L-PROLYL-L-TYROSYL-L-ALANYL-L-NORVALYL-L-TRYPTOPHYL-L-METHIONYL-N-EPSILON-(2,4-DINITROPHENYL)-L-LYSINE AMIDE
• 7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-(2,4-DINITROPHENYL)-LYS AMIDE
• N2-[2-(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-tyrosyl-L-alanyl-L-norvalyl-L-tryptophyl-L-methionyl-N6-(2,4-dinitrophenyl)-L-lysinamide
• 7-methoxycoumarin-4-acetyl-arg-pro-*lys-pro-tyr-A
• MCA-RPKPYA-NVA-WM-K(DNP)-NH2
• Mca-RPKPYA-Nva-WM-Lys(Dnp)-NH2
• 7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-*LYS- PRO-TYR-ALA
• 7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-(2,4-DINITROPHENYL)-LYS AMIDE

Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH₂

CAS: 158584-08-8

The FRET substrate Mca-RPKPYA-Nva-WMK(Dnp)-amide was hydrolyzed 60 times more rapidly by stromelysin 1 (MMP-3) (kcat/Km= 59400 M⁻¹s⁻¹) than by interstitial collagenase (MMP-1). However, it showed little discrimination between MMP-3, gelatinase A (MMP-2) (kcat/Km= 54000 M⁻¹s⁻¹), and gelatinase B (MMP-9) (kcat/Km= 55300 M⁻¹s⁻¹). Metalloelastase (MMP-12) digested this fluorogenic substrate with a kcat/Km of 243000 M⁻¹s⁻¹.

Fórmula: C₇₉H₁₀₅N₁₉O₁₉S

Pureza: > 95%

Forma y color: White Whitish Powder

Peso molecular: 1656.89

Ref: 01-4030841

7-Methoxycoumarin-4-acetyl-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-(2,4-dinitrophenyl)Lys amide

CAS: 158584-08-8

Fórmula: C₇₉H₁₀₅N₁₉O₁₉S

Peso molecular: 1656.86

Ref: 7W-GK2677

MOCAc-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH₂

CAS: 158584-08-8

MOCAc-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH₂ is a peptide that was designed to bind to ion channels. It is an activator of the nicotinic acetylcholine receptor. The peptide has also been shown to inhibit protein interactions and be a ligand for the serotonin receptor. MOCAc binds to the extracellular domain of the nicotinic acetylcholine receptor, which leads to a conformational change in the receptor's structure. This changes the shape of the channel, which allows potassium ions to flow out of the cell and sodium ions to flow in. MOCAc does not have any effects on other receptors or ion channels. MOCAc has been used as a research tool to study protein interactions and as an antibody for immunostaining and Western blotting as well as for cell biology studies.

Fórmula: C₇₉H₁₀₅N₁₉O₁₉S

Pureza: Min. 95%

Peso molecular: 1,656.9 g/mol

Ref: 3D-SMO-3167-V

Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 trifluoroacetate salt

CAS: 158584-08-8

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Fórmula: C₇₉H₁₀₅N₁₉O₁₉S

Pureza: Min. 95%

Peso molecular: 1,656.86 g/mol

Ref: 3D-FM110915