CAS 158930-17-7

Frova

Descripción:

Frova, con el número CAS 158930-17-7, es el nombre comercial del ingrediente farmacéutico activo Frovatriptan, que pertenece a la clase de medicamentos triptanes. Se utiliza principalmente para el tratamiento agudo de los ataques de migraña. Frovatriptan actúa como un agonista selectivo de los receptores de serotonina, específicamente de los subtipos 5-HT_1B y 5-HT_1D, que están involucrados en la vasoconstricción y la modulación de la liberación de neurotransmisores. Este mecanismo ayuda a aliviar los síntomas de la migraña al reducir la inflamación y constriñendo los vasos sanguíneos dilatados en el cerebro. Frovatriptan se caracteriza por su vida media relativamente larga en comparación con otros triptanes, lo que permite una eficacia prolongada en el alivio de la migraña. Se administra típicamente por vía oral y es bien tolerado, con efectos secundarios comunes que incluyen mareos, fatiga y náuseas. Al igual que otros triptanes, está contraindicado en pacientes con ciertas condiciones cardiovasculares debido al potencial de vasoconstricción. En general, Frovatriptan es una opción efectiva para el manejo de episodios agudos de migraña.

Fórmula: C₁₈H₂₅N₃O₆

InChI: InChI=1/C14H17N3O.C4H6O4.H2O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13;5-3(6)1-2-4(7)8;/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18);1-2H2,(H,5,6)(H,7,8);1H2

SMILES: CNC1CCc2c(C1)c1cc(ccc1[nH]2)C(=N)O.C(CC(=O)O)C(=O)O.O

Sinónimos:

• (3R)-2,3,4,9-Tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide Butanedioic Acid Monohydrate
• Frovatriptan Succinate Monohydrate
• Frovelan
• Migard
• (3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide
• Frovatriptan succinate hydrate
• 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (R)-, butanedioate (1:1), monohydrate
• Miguard
• Frova
• Butanedioic acid, compd. with (R)-2,3,4,9-tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide (1:1), monohydrate
• Frovatriptan succinate [usan]

Frovatriptan succinate monohydrate

CAS: 158930-17-7

Frovatriptan succinate is a drug that belongs to the class of anti-migraine drugs. It is a selective serotonin receptor agonist and inhibits the release of neurotransmitters from nerve endings in the brain. Frovatriptan succinate has been shown to be effective for migraine, with significant relief starting about 30 minutes after taking the drug. It has been shown to be well tolerated and effective in patients with hepatic impairment, although it should not be used in patients with severe liver disease. Frovatriptan succinate is marketed as a controlled-release preparation that can be taken once per day. The drug binds to plasma proteins and has a short half-life (approximately 2 hours). It is metabolized by hepatic cytochrome P450 enzymes and excreted primarily through the kidneys. Frovatriptan succinate may also interact with nonsteroidal anti-inflammatory drugs, such as aspirin or ibuprofen, which could increase the risk

Fórmula: C₁₄H₁₇N₃O•C₄H₆O₄•H₂O

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 379.41 g/mol

Ref: 3D-IGA93017

Frovatriptan succinate hydrate

CAS: 158930-17-7

Frovatriptan succinate hydrate

Pureza: ≥98%

Peso molecular: 379.41g/mol

Ref: 54-BUP09657

rac Frovatriptan-d3 Succinate Monohydrate (2:1:1)

Producto controlado

CAS: 158930-14-4, 158930-17-7

Fórmula: C₁₄D₃H₁₄N₃O·C₄H₆O₄·H₂O

Forma y color: Neat

Peso molecular: 382.426

Ref: TR-F768502

Frovatriptan Succinate

CAS: 158930-17-7

Analgesics, antipyretics and non-hormonal anti-inflammatory agents

Fórmula: C₁₄H₁₇N₃O·C₄H₆O₄·H₂O

Forma y color: White Off-White Powder

Peso molecular: 379.17434

Ref: 45-1286413

Frovatriptan Succinate Monohydrate

Producto controlado

CAS: 158930-17-7

Fórmula: C₁₄H₁₇N₃O·C₄H₆O₄·H₂O

Forma y color: Neat

Peso molecular: 379.41

Ref: TR-F768500

Frovatriptan succinate hydrate

CAS: 158930-17-7

Frovatriptan treats all migraine types, nausea, vomiting, light/sound sensitivity, and prevents menstrual migraines; it targets 5-HT1B/D and 5-HT7 receptors.

Fórmula: C₁₈H₂₅N₃O₆

Pureza: 99.66%

Forma y color: Solid

Peso molecular: 379.41

Ref: TM-T11326

Crotamiton Impurity 1

CAS: 158930-17-7

Fórmula: C₁₁H₁₃NO

Peso molecular: 175.23

Ref: 4Z-C-308004

Frovatriptan (succinate hydrate)

CAS: 158930-17-7

Fórmula: C₁₈H₂₅N₃O₆

Pureza: 99%

Forma y color: Solid

Peso molecular: 379.4076

Ref: IN-DA001R0A