CAS 159857-81-5

N-[6-(2,5-Dihidro-2,5-dioxo-1H-pirrol-1-il)-1-oxohexil]-L-valil-N5-(aminocarbonil)-N-[4-[[[(4-nitrofenoxi)carbonil]oxi]metil]fenil]-L-ornitinamida

Descripción:

La sustancia química N-[6-(2,5-Dihidro-2,5-dioxo-1H-pirrol-1-il)-1-oxohexil]-L-valil-N5-(aminocarbonil)-N-[4-[[[(4-nitrofenoxi)carbonil]oxi]metil]fenil]-L-ornitinamida, con número CAS 159857-81-5, es un compuesto orgánico complejo caracterizado por su estructura multifuncional. Presenta una combinación de aminoácidos, específicamente L-valina y L-ornitina, que contribuyen a su potencial actividad biológica. La presencia de un anillo de pirrol y varios grupos funcionales, incluidos los moieties nitrofenoxi y carbonilo, sugiere que puede exhibir una reactividad significativa y posibles interacciones con objetivos biológicos. Este compuesto probablemente sea soluble en disolventes polares debido a sus componentes de aminoácidos y grupos funcionales polares. Su estructura intrincada también puede indicar aplicaciones potenciales en química medicinal, particularmente en el desarrollo de terapias basadas en péptidos o como sonda bioquímica. Sin embargo, serían necesarios estudios detallados sobre sus propiedades farmacológicas, estabilidad y síntesis para comprender completamente sus características y posibles usos.

Fórmula: C₃₅H₄₃N₇O₁₁

InChI: InChI=1S/C35H43N7O11/c1-22(2)31(40-28(43)8-4-3-5-20-41-29(44)17-18-30(41)45)33(47)39-27(7-6-19-37-34(36)48)32(46)38-24-11-9-23(10-12-24)21-52-35(49)53-26-15-13-25(14-16-26)42(50)51/h9-18,22,27,31H,3-8,19-21H2,1-2H3,(H,38,46)(H,39,47)(H,40,43)(H3,36,37,48)/t27-,31-/m0/s1

Clave InChI: InChIKey=HYSPJPGXSALJRR-DHIFEGFHSA-N

SMILES: [C@H](C(NC1=CC=C(COC(OC2=CC=C(N(=O)=O)C=C2)=O)C=C1)=O)(NC([C@@H](NC(CCCCCN3C(=O)C=CC3=O)=O)C(C)C)=O)CCCNC(N)=O

Sinónimos:

• Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate
• 4-((S)-2-((S)-2-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl(4-nitrophenyl)carbonate
• MC-Val-Cit-PAB-PNP
• N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-L-ornithinamide
• L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
• MC-VAL-CIT-PAB-PNB
• Mc-Val-Cit-PABC-PNP (Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate)
• N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-
• MC-VC-PAB-PNP,Mc-Val-Cit-PABC-PNP
• 4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl 4-nitrophenyl carbonate,linker
• N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide
• [4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
• Mc-Val-Cit-PABC-PNP(VCMMAE linker)
• N-(6-Maleimidocaproyl)-L-valyl-N5-carbamoyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl
• VCMMAE linker
• MC-Val-Cit-PABC
• L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- ISO 9001：2015 REACH
• L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(5-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-
• CS-1787
• Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate Mc-Val-Cit-PABC-PNP
• L-Ornithinamide
• JACS-159857-81-5
• Mc-Val-Cit-PABC-PNP
• MC-Val-Cit-PAB-PNP (ADC peptide linker)
• MC-VAL-CIT-PABC-PNP;MC-VC-PAB-PNP;MC-VAL-CIT-PAB-PNB;MC-VAL-CIT-PAB-PNP

L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-

CAS: 159857-81-5

Fórmula: C₃₅H₄₃N₇O₁₁

Pureza: 97%

Forma y color: Solid

Peso molecular: 737.7562

Ref: IN-DA001RFZ

Mc-Val-Cit-Pab-Pnp

CAS: 159857-81-5

Mc-Val-Cit-Pab-Pnp

Pureza: 98%

Peso molecular: 737.77g/mol

Ref: 54-OR1013722

MC-Val-Cit-PABC-PNP

CAS: 159857-81-5

MC-Val-Cit-PABC-PNP

Pureza: ≥95%

Peso molecular: 737.76g/mol

Ref: 54-BUP16203

MC-Val-Cit-PABC-PNP

CAS: 159857-81-5

MC-Val-Cit-PABC-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker.

Fórmula: C₃₅H₄₃N₇O₁₁

Pureza: 97.2% - 98.055%

Forma y color: Solid

Peso molecular: 737.76

Ref: TM-T3503

Mc-Val-Cit-PABC-PNP

CAS: 159857-81-5

Val-Cit-based peptide linker with PABC spacer. This activated peptide linker is cleaved by cathepsin enzymes for intracellular payload release.

Fórmula: C₃₅H₄₃N₇O₁₁

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 737.76 g/mol

Ref: 3D-FM160946

Mc-Val-Cit-PABC-PNP

CAS: 159857-81-5

Pureza: 98%

Peso molecular: 737.7670288

Ref: 10-F869465

Mc-Val-Cit-PABC-PNP

CAS: 159857-81-5

Fórmula: C₃₅H₄₃N₇O₁₁

Pureza: >97.0%(HPLC)

Forma y color: White to Orange to Green powder to crystaline

Peso molecular: 737.77

Ref: 3B-M3209

Mc-Val-Cit-PABC-PNP

Producto controlado

CAS: 159857-81-5

Fórmula: C₃₅H₄₃N₇O₁₁

Forma y color: Neat

Peso molecular: 737.756

Ref: TR-M246070