CAS 1616282-53-1

1,2-Diaminoethane trityl resin

CAS: 1616282-53-1

1,2-Diaminoethane trityl resin is a versatile solid support widely used in peptide synthesis and proteomics research. This resin comprises a trityl group attached to a polystyrene backbone, functionalized with 1,2-diaminoethane groups, enabling its role as a covalent cross-linker for plasma membrane binding. The resin's primary applications include solid-phase peptide synthesis, antibody immobilization for immunoassays, and various proteomics studies. Its unique structure allows for the synthesis of peptidyl-aminoethylamines using Fmoc solid-phase peptide synthesis (SPPS) techniques, which offers a free primary amine at the C-terminus for further modifications. Its trityl linker allows mild cleavage conditions using TFA, compatible with most Fmoc-protected amino acids. The resin's lower loading capacity benefits challenging sequence synthesis to optimize coupling efficiency with typical coupling agents (e.g. HATU, PyBOP, HBTU, and HOBt), especially for initial amino acids, as the ethylenediamine spacer may affect these reactions. The resulting peptides, featuring a flexible C-terminal amine, are valuable for creating peptide-drug conjugates, fluorescent probes, and other bioactive molecules.

Pureza: Min. 95%

Ref: 3D-FD48110