CAS 161748-29-4

GLP-1 (9-36) AMIDA (HUMANO, BOVINO, COBAYA, RATÓN, PORCINO, RATA)

Descripción:

El amida GLP-1 (9-36) es un péptido derivado del péptido similar al glucagón-1 (GLP-1), que desempeña un papel crucial en el metabolismo de la glucosa y la regulación del apetito. Este fragmento específico, que es una forma de amida, se produce a través de la escisión enzimática del GLP-1 de longitud completa. Se caracteriza por su capacidad para interactuar con los receptores de GLP-1, aunque con una potencia y eficacia diferentes en comparación con sus contrapartes más largas. Se sabe que el péptido exhibe diversas actividades biológicas, incluida la modulación de la secreción de insulina y la inhibición de la liberación de glucagón, lo que contribuye a sus posibles aplicaciones terapéuticas en el manejo de la diabetes. El número CAS 161748-29-4 identifica de manera única este compuesto, que es relevante en entornos de investigación en múltiples especies, incluidos humanos, bovinos, cobayas, ratones, porcinos y ratas. Su estabilidad, solubilidad y bioactividad lo convierten en un tema de interés en estudios farmacológicos destinados a comprender los trastornos metabólicos y desarrollar tratamientos relacionados.

Fórmula: C₁₄₀H₂₁₄N₃₆O₄₃

Sinónimos:

• Proglucagon (80-107) Amide (Human, Bovine, Guinea Pig, Mouse, Porcine, Rat)
• Preproglucagon (100-127) Amide (Human, Bovine, Guinea Pig, Mouse, Porcine, Rat)
• H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Nh2
• Glucagon-Like Peptide 1 (9-36) Amide (Human, Bovine, Guinea Pig, Mouse, Porcine, Rat)

GLP-1 (9-36) amide (human, bovine, guinea pig, mouse, porcine, rat)

CAS: 161748-29-4

Glucagon-like peptide-1 (GLP-1) is efficiently degraded by the enzyme dipeptidyl peptidase IV (DPP IV), yielding the major metabolite GLP-1 (9-36) amide. GLP-1 (9-36) amide does not affect glucose disposal in mice either in the presence or absence of intact GLP-1 receptors or in the presence or absence of stimulated insulin levels. This suggests that the GLP-1 metabolite is not involved in the regulation of glucose homeostasis. Elahi et al. have shown that this GLP-1 metabolite acts as a weak insulinotropic agent and inhibits hepatic glucose production.

Fórmula: C₁₄₀H₂₁₄N₃₆O₄₃

Pureza: ≥ 98%

Forma y color: White Powder

Peso molecular: 3089.46

Ref: 01-4027697

GLP-1 (9-36) amide

CAS: 161748-29-4

GLP-1 (9-36) amide is an antagonist at the human GLP-1 receptor.

Fórmula: C₁₄₀H₂₁₄N₃₆O₄₃

Pureza: 97%

Forma y color: Solid

Peso molecular: 3089.41

Ref: TM-TP2252

GLP-1 (9-36) amide trifluoroacetate

CAS: 161748-29-4

GLP-1 (9-36) amide trifluoroacetate is a bioactive peptide fragment derived from the full-length glucagon-like peptide-1 (GLP-1), an incretin hormone. It is typically obtained through enzymatic cleavage or synthetic processes involving solid-phase peptide synthesis. The mode of action of GLP-1 (9-36) amide involves binding to and modulating GLP-1 receptors, although it lacks the insulinotropic activity of its precursor GLP-1 (7-36) amide, making it a valuable tool for studying distinct signaling pathways and metabolic effects.

Fórmula: C₁₄₀H₂₁₄N₃₆O₄₃

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 3,089.41 g/mol

Ref: 3D-FG109155

GLP-1 (9-36) amide

CAS: 161748-29-4

Natural cleavage product of GLP-1 which, unlike GLP-1, does not affect either insulin secretion or glucose homeostasis.  GLP-1(9-36) has low affinity for, and acts as an antagonist to, the GLP-1 receptor.GLP-1 (9-36) does however display unique biological activities such as beneficial cardiovascular effects and reducing the production of reactive oxygen species (ROS). GLP-1 (9-36) also exerts important physiological effects on neuronal plasticity in the hippocampus, and inhibits chemokine-induced migration of human CD4-positive lymphocytes.GLP-1 (9-36) is formed from the breakdown of biologically active but highly unstable GLP-1 (7-36) amide by the ubiquitous serine protease, dipeptidyl peptidase-IV (DPP-IV).

Forma y color: Powder

Peso molecular: 3,087.6 g/mol

Ref: 3D-CRB1000982

GLP-1 (9-36) amide

CAS: 161748-29-4

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Fórmula: C₁₄₀H₂₁₄N₃₆O₄₃

Peso molecular: 3,089.44 g/mol

Ref: 3D-PP49952

GLP-1 (9-36) amide (human, bovine, guinea pig, mouse, porcine, rat)

CAS: 161748-29-4

Catalogue peptide; min. 95% purity

Fórmula: C₁₄₀H₂₁₄N₃₆O₄₃

Peso molecular: 3,089.48 g/mol

Ref: 3D-VAC-00364