CAS 1632125-79-1

5-Fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one

CAS: 1632125-79-1

5-Fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one

Pureza: 97%

Peso molecular: 479.56g/mol

Ref: 54-PC1006780

ML-345

CAS: 1632125-79-1

ML-345, Selective IDE inhibitor (IC50=188 nM) targeting Cys819, for type 2 diabetes and Alzheimer's research.

Fórmula: C₂₁H₂₂FN₃O₅S₂

Pureza: 99.21%

Forma y color: Solid

Peso molecular: 479.55

Ref: TM-T35802

ML345

Producto controlado

CAS: 1632125-79-1

Applications ML345 is a small molecule inhibitor of the insulin-degrading enzyme (IDE).
References Bannister, T.D., et. al.: National Center for Biotechnology Information (US), (2010-)

Fórmula: C₂₁H₂₂FN₃O₅S₂

Forma y color: Neat

Peso molecular: 479.54

Ref: TR-M425355

ML345

CAS: 1632125-79-1

ML345 is a hydroxamic acid that inhibits the enzyme acetylcholinesterase and thus prevents the breakdown of acetylcholine. It is used in the treatment of Alzheimer's disease and other conditions related to cholinergic deficiency. ML345 has been shown to be effective in treating Alzheimer's disease by inhibiting amyloid-β aggregation, which may be due to its ability to inhibit the growth rate of amyloid plaques. Mechanistic studies have shown that ML345 binds to a pharmacophore consisting of an aromatic ring with a carboxylic acid group at the para position on one side, and a hydrogen bond donor on the other side. The molecule is also able to penetrate into cells through osmosis, allowing it to reach its target site. In addition, ML345 has been found to have antimicrobial properties against Gram-positive bacteria such as Staphylococcus aureus or Streptococcus pneumoniae.

Fórmula: C₂₁H₂₂FN₃O₅S₂

Pureza: Min. 95%

Peso molecular: 479.54 g/mol

Ref: 3D-HQC12579