CAS 1633044-56-0

FIIN-2

CAS: 1633044-56-0

FIIN-2

Pureza: ≥95%

Peso molecular: 634.73g/mol

Ref: 54-BUP03845

FIIN-2

CAS: 1633044-56-0

FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.

Fórmula: C₃₅H₃₈N₈O₄

Pureza: 97.82% - 99.65%

Forma y color: Crystalline Solid

Peso molecular: 634.73

Ref: TM-T6836

FIIN-2

CAS: 1633044-56-0

FIIN-2 is a member of the fibroblast growth factor family and is involved in angiogenesis. It has been shown to be expressed at high levels in urothelial carcinoma cells, suggesting that it may have a role in tumor growth and progression. FIIN-2 expression was also seen in the microenvironment of breast cancer tumors. FIIN-2 has been shown to activate tyrosine kinase receptors, which are potential drug targets for antiangiogenic therapy. FIIN-2 expression can be detected by immunohistochemistry or immunofluorescence staining with monoclonal antibodies to this protein. The crystal structure of FIIN-2 has also been determined using X-ray crystallography, revealing that it shares structural similarities with epidermal growth factor receptor (EGFR) and Herceptin (trastuzumab), which are currently used as drugs for targeting breast cancer cells expressing Her2+.

Fórmula: C₃₅H₃₈N₈O₄

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 634.73 g/mol

Ref: 3D-BF179868