CAS 16561-29-8

Forbol 12-miristato 13-acetato

Descripción:

Forbol 12-miristato 13-acetato (PMA) es un compuesto orgánico sintético derivado del producto natural forbol, que se obtiene de las semillas de la planta Jatropha. Se clasifica como un éster de forbol y es conocido por su papel como un potente promotor tumoral y activador de la proteína quinasa C (PKC). PMA es un polvo cristalino blanco a blanco amarillento que es soluble en disolventes orgánicos como el etanol y el dimetilsulfóxido (DMSO), pero tiene una solubilidad limitada en agua. El compuesto exhibe una variedad de actividades biológicas, incluida la inducción de la proliferación y diferenciación celular, lo que lo convierte en una herramienta valiosa en la investigación del cáncer y estudios de biología celular. PMA se utiliza a menudo en entornos de laboratorio para estudiar las vías de transducción de señales y los mecanismos de tumorigenesis. Sin embargo, debido a sus potentes efectos biológicos, debe manejarse con cuidado en entornos de investigación. Su estructura química presenta un grupo miristato y un grupo acetato, lo que contribuye a su reactividad y propiedades biológicas.

Fórmula: C₃₆H₅₆O₈

InChI: InChI=1/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24?,27-,28?,30+,32+,34+,35+,36+/m0/s1

Clave InChI: InChIKey=PHEDXBVPIONUQT-RGYGYFBISA-N

SMILES: O(C(C)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)[C@H]2OC(CCCCCCCCCCCCC)=O)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]

Sinónimos:

• (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
• 1,6,8-Beta-Tetramethyl-L)-9A-Acetate9-Myristate
• 12-O-Tetradecanoylphorbol 13-acetate
• 12-O-Tetradecanoylphorbolacetate
• 12-O-Tetradekanoylphorbol-13-Acetat
• 12-Tetradecanoylphorbol 13-acetate
• 12-Tetradecanoylphorbol 13-monoacetate
• 12-Tetradecanoylphorbol13-Monoacetate
• 13-O-Acetylphorbol 12-myristate
• 1H-Cyclopropa[3,4]benz[1,2-e]azulene, tetradecanoic acid deriv.
• 4β-Phorbol 12-myristate 13-acetate
• Factor A1
• Factor A1 (croton oil)
• Factor A₁
• Factor A₁ (croton oil)
• Myristic acid, 9-ester with 1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9a-acetate, (+)-
• Nsc 262244
• PMA
• PMA (tumor promoter)
• Pd 616
• Phorbol 12-tetradecanoate 13-acetate
• Phorbol myristate acetate
• TPA
• TPA (phorbol derivative)
• Tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester
• Tetradecanoic acid, 9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester, [1aR-(1aα,1bβ,4aβ,7aα,7bα,8α,9β,9aα)]-
• Tetradecanoylphorbol acetate
• β-Phorbol 12-myristate 13-acetate
• 4)benz(1,2-e)azulen-5-one9a-acetate,(+)-ethyl-5h-cyclopropa(
• abeta,7balpha,9beta,9aalpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8alpha-tetram
• PHORBOL (12-MYRISTOYL-13-ACETYL)
• 8,9,9a-decahydro-4a-alpha,7b-beta,9-alpha,9a-beta-tetrahydroxy-3-(hydroxymethy
• PHORBOL 12-MYRISTATE 13-ACETATE
• 4BETA,9ALPHA,12BETA,13ALPHA,20-PENTA-HYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
• 4BETA-PHORBOL 12-MYRISTATE 13-ACETATE
• (1AR,1BS,4AR,7AS,7BS,8R,9R,9AS)-9A-(ACETYLOXY)-1A,1B,4,4A,5,7A,7B,8,9,9A-DECAHYDRO-4A,7B-DIHYDROXY-3-(HYDROXYMETHYL)-1,1,6,8-TETRAMETHYL-5-OXO-1H-CYCLOPROPA[3,4]BENZ[1,2-E]AZULEN-9-YL TETRADECANOATE
• 5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-beta,1b-alpha,4,4a,7a-beta,7b,
• 12-TETRADECANOYL PHORBOL 13-ACETATE
• 4ALPHA,9ALPHA,12BETA,13ALPHA,20-PENTAHYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
• 13-o-acetylphorbol12-myristate

Phorbol 12-myristate 13-acetate, 95%

CAS: 16561-29-8

Activates protein kinase C and promotes skin tumors in mice

Fórmula: C₃₆H₅₆O₈

Pureza: 95%

Forma y color: White to pale cream, Powder, film or foam, solid

Peso molecular: 616.84

Ref: 02-J63916

Tetradecanoic acid, (1aR,​1bS,​4aR,​7aS,​7bS,​8R,​9R,​9aS)​-​9a-​(acetyloxy)​-​1a,​1b,​4,​4a,​5,​7a,​7b,​8,​9,​9a-​decahydro-​4a,​7b-​dihydroxy-​3-​(hydroxymethyl)​-​1,​1,​6,​8-​tetramethyl-​5-​oxo-​1H-​cyclopropa[3,​4]​benz[1,​2-​e]​azulen-​9-​yl ester

CAS: 16561-29-8

Fórmula: C₃₆H₅₆O₈

Pureza: 95%

Forma y color: Solid

Peso molecular: 616.8250

Ref: IN-DA00AOO4

Phorbol 12-myristate 13-Acetate

CAS: 16561-29-8

Phorbol 12-myristate 13-Acetate

Pureza: 95%

Peso molecular: 616.825g/mol

Ref: 54-OR1030780

Phorbol 12-myristate 13-acetate

CAS: 16561-29-8

Phorbol 12-myristate 13-acetate

Pureza: ≥98%

Peso molecular: 616.83g/mol

Ref: 54-BUP08804

Phorbol 12-Myristate 13-Acetate

CAS: 16561-29-8

Phorbol 12-Myristate 13-Acetate

Fórmula: C₃₆H₅₆O₈

Pureza: 98%

Forma y color: amorphous solid

Peso molecular: 616.83g/mol

Ref: 54-BIP1020

Phorbol-12-Myristate-13-Acetate

CAS: 16561-29-8

Fórmula: C₃₆H₅₆O₈

Pureza: 95%~99%

Peso molecular: 616.836

Ref: BP-BP0021

Phorbol 12-myristate 13-acetate

CAS: 16561-29-8

Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.

Fórmula: C₃₆H₅₆O₈

Pureza: 98.55% - >99.99%

Forma y color: White To Off-White Solid

Peso molecular: 616.83

Ref: TM-TQ0198

Phorbol 12-myristate 13-acetate

CAS: 16561-29-8

Fórmula: C₃₆H₅₆O₈

Pureza: (HPLC) ≥ 98.0%

Forma y color: White to off-white solid

Peso molecular: 616.83

Ref: 7W-GK8317

4Beta-Phorbol 12-Myristate 13-Acetate

CAS: 16561-29-8

Fórmula: C₃₆H₅₆O₈

Forma y color: Neat

Peso molecular: 616.82

Ref: TR-P353475

Phorbol-12-myristate-13-acetate

CAS: 16561-29-8

Phorbol-12-myristate-13-acetate is a phorbol ester that inhibits the activity of protein kinase C. It binds to the response element on DNA and blocks RNA synthesis, leading to cell death. Phorbol 12-myristate 13-acetate has been shown to inhibit the proliferation of human squamous cells in culture, which may be caused by its ability to inhibit the cell cycle. This drug also has been shown to inhibit the production of cytokines such as interleukin-1β and tumor necrosis factor α (TNFα) in human polymorphonuclear leukocytes (PMNLs).

Fórmula: C₃₆H₅₆O₈

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 616.83 g/mol

Ref: 3D-FP15184

Phorbol-12-myristate-13-acetate

CAS: 16561-29-8

M02249 - Phorbol-12-myristate-13-acetate

Fórmula: C₃₆H₅₆O₈

Pureza: 98%

Forma y color: Amorphous solid in the form of a film/foam

Peso molecular: 616.836

Ref: 10-M02249