CAS 168650-46-2

(Asp371)-Tirosinasa (369-377) (humano)

Descripción:

(Asp371)-Tirosinasa (369-377) es un péptido derivado de la enzima tirosinasa humana, que juega un papel crucial en la biosíntesis de melanina, el pigmento responsable de la coloración en la piel, el cabello y los ojos. Esta secuencia de péptidos específica es parte de la proteína tirosinasa más grande y está involucrada en la actividad catalítica de la enzima, facilitando la oxidación de compuestos fenólicos para producir melanina. El número CAS 168650-46-2 identifica este péptido en particular, indicando su identidad química única. La tirosinasa es una enzima que contiene cobre, y su actividad se ve influenciada por varios factores, incluyendo pH, temperatura y la presencia de inhibidores o activadores. El estudio de este péptido puede proporcionar información sobre los trastornos de la pigmentación de la piel y enfoques terapéuticos potenciales para condiciones como el albinismo o la hiperpigmentación. Además, comprender la estructura y función de la tirosinasa puede ayudar en el desarrollo de productos cosméticos destinados a aclarar la piel o proteger contra la radiación UV.

Fórmula: C₄₂H₆₆N₁₀O₁₆S₂

Sinónimos:

• [Asp370]-Tyrosinase (368-376)
• Asp371, Tyrosinase 369-777, Human
• Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val
• Ymdgtmsqv

[Asp371]-Tyrosinase (369-377), human

CAS: 168650-46-2

Tyrosinase (369-377,YMDGTMSQV) originates from tyrosinase and needs TAP and proteosome for cell presentation.

Fórmula: C₄₂H₆₆N₁₀O₁₆S₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 1031.16

Ref: TM-TP1623

[Asp371]-Tyrosinase (369-377), human

CAS: 168650-46-2

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Fórmula: C₄₂H₆₆N₁₀O₁₆S₂

Peso molecular: 1,031.2 g/mol

Ref: 3D-PP50380

[Asp371] Tyrosinase(369-377), human

CAS: 168650-46-2

H-YMDGTMSQVA-OH peptide, corresponding to 369-377 amino acids of enzyme tyrosinase. As a member of the tyrosinase family the corresponding enzyme catalyzes monopheol hydroxylation, dihydroxyindole and catechol dehydrogenation. It is a key enzyme in the conversion of tyrosine to melanin.

Fórmula: C₄₂H₆₆N₁₀O₁₆S₂

Pureza: Min. 95%

Peso molecular: 1,031.16 g/mol

Ref: 3D-FA73646

(Asp371)-Tyrosinase (369-377) (human) acetate salt

CAS: 168650-46-2

Tyrosinase protein:
Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV) is a human tyrosinase-derived (369-377) peptide by posttranslational conversion of the sequence YMNGTMSQV. Tyrosinase is an oxidase membrane-bound protein. Tyrosinase play a key role in the melanin synthesis pathway. Tyrosinase is presented on the surface of HLA-A*02:01 melanomas and also expressed in melanocytes. Tyrosinase has been still suggested to be a tumor antigen and might be implicated in improvement of immunotherapeutic strategies such as for efficient anticancer vaccine development.
Applications of Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV):
Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV) is used to stimulate specific cytotoxic T lymphocytes (CTL) in PBMCs and then to analyze CTL response especially the cytokine production by ELISPOT assay. Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV) is also involved in experimental therapies of metastatic melanoma by allogeneic hematopoietic stem cell transplantation. In fact, cytotoxic T cells were generated from peripherical blood mononuclear cells (PBMCs) of HLA-A*02:01 healthy donors after being stimulated by injection of Asp371 antigen (2). This strategy raises issues which concern the graft versus tumor (GvT) effect and graft versus host disease (GvHD).

Fórmula: C₄₂H₆₆N₁₀O₁₆S₂

Pureza: Min. 95%

Peso molecular: 1,031.16 g/mol

Ref: 3D-FA109106

(Asp371)-Tyrosinase (369-377) (human) trifluoroacetate salt

CAS: 168650-46-2

Trifluoroacetate salt

Fórmula: C₄₂H₆₆N₁₀O₁₆S₂

Pureza: Min. 95%

Peso molecular: 1,031.16 g/mol

Ref: 3D-FA110240