CAS 169332-61-0

acetil-asp-glu-val-asp-7-amido-4-*metilcumarina

Descripción:

El acetil-asp-glu-val-asp-7-amido-4-metilcumarina, comúnmente conocido como un sustrato peptídico, es un compuesto sintético que se utiliza a menudo en investigaciones bioquímicas, particularmente en estudios que involucran proteasas y actividad enzimática. Este compuesto presenta una estructura peptídica compuesta por cuatro aminoácidos: ácido aspártico (Asp), ácido glutámico (Glu) y valina (Val), unidos en una secuencia específica. La presencia del grupo 7-amido-4-metilcumarina actúa como un grupo reportero fluorescente, permitiendo el monitoreo de reacciones enzimáticas a través de mediciones de fluorescencia. Esta característica lo hace particularmente valioso en ensayos para enzimas proteolíticas, donde la ruptura del enlace peptídico libera la señal fluorescente. El compuesto es típicamente soluble en disolventes orgánicos y exhibe estabilidad bajo condiciones de laboratorio estándar. Su diseño permite especificidad en las interacciones entre enzimas y sustratos, lo que lo convierte en una herramienta útil tanto en la investigación básica como aplicada en bioquímica y biología molecular.

Fórmula: C₃₀H₃₇N₅O₁₃

Sinónimos:

• Ac-Asp-Glu-Val-Asp-AMC
• Ac-Devd-Amc

Ac-Asp-Glu-Val-Asp-AMC

CAS: 169332-61-0

A continuous fluorometric assay employing Ac-DEVD-AMC has been developed for the measurement of caspase-3, a cysteine protease also called apopain, Yama or CPP-32. The design of this substrate Ac-DEVD-AMC was based on the substrate motif that has been used successfully with caspase-1, using the poly(ADP-ribose) polymerase cleavage site P₁-P₄ tetrapeptide.

Fórmula: C₃₀H₃₇N₅O₁₃

Pureza: 97.3%

Forma y color: White Crystalline Powder

Peso molecular: 675.65

Ref: 01-4026262

Ac-Asp-Glu-Val-Asp-AMC ammonium salt

CAS: 169332-61-0

Fórmula: C₃₀H₃₇N₅O₁₃

Pureza: 97%

Forma y color: Solid

Peso molecular: 675.6405

Ref: IN-DA01E6VJ

Ac-DEVD-AMC

CAS: 169332-61-0

Ac-DEVD-AMC

Pureza: ≥98%

Peso molecular: 675.64g/mol

Ref: 54-BUP00571

N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin

CAS: 169332-61-0

Fórmula: C₃₀H₃₇N₅O₁₃

Pureza: (HPLC) ≥ 95.0%

Forma y color: Conflicting attributes defined

Peso molecular: 675.64

Ref: 7W-GK6157

Ac-DEVD-AMC

CAS: 169332-61-0

Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .

Fórmula: C₃₀H₃₇N₅O₁₃

Pureza: 98.20%

Forma y color: White Powder

Peso molecular: 675.64

Ref: TM-T18909

Ac-Asp-Glu-Val-Asp-AMC ammonium salt

CAS: 169332-61-0

Ac-Asp-Glu-Val-Asp-AMC ammonium salt is a small molecule that is used as a tool to study apoptosis in vitro. Ac-Asp-Glu-Val-Asp-AMC ammonium salt induces apoptosis by blocking the mitochondrial membrane potential and inducing the release of cytochrome c from mitochondria into the cytoplasm. This drug also induces activation of caspase 3, which initiates the cascade of events leading to cell death. Ac-Asp-Glu-Val-Asp-AMC ammonium salt has been shown to have an antiangiogenic effect on hl60 cells. This effect may be due to its ability to inhibit expression of survivin, a protein that protects cells from apoptosis. The efficacy of this drug in an experimental model has been shown to be dependent on toll like receptor (TLR) signaling pathways and mitochondrial function.br>

Fórmula: C₃₀H₃₇N₅O₁₃•NH₃

Pureza: Min. 97 Area-%

Forma y color: Powder

Peso molecular: 692.67 g/mol

Ref: 3D-FA110568

Ac-Asp-Glu-Val-Asp-AMC

CAS: 169332-61-0

Ac-Asp-Glu-Val-Asp-AMC is an ion channel activator. It binds to the receptor site of the ligand, which causes a conformational change in the protein that leads to the opening of the ion channel. Ac-Asp-Glu-Val-Asp-AMC is a peptide with a molecular weight of 927.6 and is soluble in water. This product has been shown to be stable under various conditions and can be used as research tool or pharmacological agent. Ac-Asp-Glu-Val-Asp-AMC is also an antibody that binds to an epitope on human CD8 protein and can be used for cell biology studies, such as activation and inhibition of these proteins.

Fórmula: C₃₀H₃₇N₅O₁₃

Pureza: Min. 95%

Peso molecular: 675.64 g/mol

Ref: 3D-SAP-3171-V