CAS 171228-49-2
:Posaconazol
Descripción:
Posaconazol es un agente antifúngico triazólico utilizado principalmente para la prevención y el tratamiento de infecciones fúngicas, particularmente en pacientes inmunocomprometidos. Exhibe un amplio espectro de actividad contra varios hongos, incluyendo especies de Candida y Aspergillus. La estructura química de Posaconazol presenta un anillo triazólico, que es crucial para su mecanismo de acción, ya que inhibe la enzima lanosterol 14α-desmetilasa, interrumpiendo la síntesis de ergosterol en las membranas celulares fúngicas. Esto conduce a un aumento de la permeabilidad de la membrana y, en última instancia, a la muerte celular. Posaconazol se caracteriza por su relativamente baja solubilidad en agua, lo que puede afectar su biodisponibilidad; sin embargo, está disponible en varias formulaciones, incluyendo suspensión oral y tabletas de liberación retardada. El fármaco se metaboliza principalmente en el hígado, y su farmacocinética puede verse influenciada por factores como la ingesta de alimentos y medicamentos concomitantes. Los efectos secundarios comunes pueden incluir trastornos gastrointestinales y elevaciones de las enzimas hepáticas. En general, Posaconazol es una opción terapéutica vital en el manejo de infecciones fúngicas invasivas, particularmente en poblaciones de alto riesgo.
Fórmula:C37H42F2N8O4
InChI:InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1
Clave InChI:InChIKey=RAGOYPUPXAKGKH-XAKZXMRKSA-N
SMILES:C([C@@]1(C[C@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N([C@H]([C@H](C)O)CC)N=C5)CO1)C6=C(F)C=C(F)C=C6)N7C=NC=N7
Sinónimos:- (2xi)-1,4-anhydro-2,3,5-trideoxy-4-(2,4-difluorophenyl)-2-({4-[4-(4-{1-[(2S,3S)-2-hydroxypentan-3-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenoxy}methyl)-5-(1H-1,2,4-triazol-1-yl)-D-glycero-pentitol
- 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-<span class="text-smallcaps">D</span>-threo-pentitol
- 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
- 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
- <span class="text-smallcaps">D</span>-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
- Hydroxypropyl]-2,4-Dihydro-3H-1,2,4-Triazol-3-One
- Noxafil
- Posaconazole SP
- Posaconazole for research
- Sch 56592
- D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
- 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-(1-ethyl-2-hydroxypropyl)-2,4-dihydro-, [3R-[3α(1S*,2S*),5α]]-
- Ver más sinónimos
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Encontrado 19 productos.
Posaconazole
CAS:Fórmula:C37H42F2N8O4Pureza:>98.0%(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:700.79Posaconazole
CAS:<p>Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi</p>Fórmula:C37H42F2N8O4Forma y color:White PowderPeso molecular:700.329714-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
CAS:Fórmula:C37H42F2N8O4Pureza:98%Forma y color:SolidPeso molecular:700.7774Ref: IN-DA0039KV
1g77,00€5g168,00€10g288,00€1kgA consultar25g540,00€100gA consultar500gA consultar50mg24,00€100mg29,00€250mg44,00€Posaconazole-d5
CAS:Fórmula:C37H37D5F2N8O4Forma y color:White To Off-White SolidPeso molecular:705.82Posaconazole
CAS:Fórmula:C37H42F2N8O4Pureza:98.0 - 102.0 % (dry basis)Forma y color:White to off-white powderPeso molecular:700.78Posaconazole
CAS:<p>Posaconazole (POS) is a sterol C14ɑ demethylase inhibitor (IC50: 0.25 nM).</p>Fórmula:C37H42F2N8O4Pureza:99.72% - >99.99%Forma y color:White SolidPeso molecular:700.78Posaconazole Impurity 92
CAS:Fórmula:C14H15F2N3O2Forma y color:White To Off-White SolidPeso molecular:295.29Posaconazole - Bio-X ™
CAS:<p>Posaconazole is a triazole antifungal agent that inhibits the 14-alpha demethylase enzyme. This drug prevents the formation of fungal cell walls thus leading to fungal cell lysis. Posaconazole is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species in severely immunocompromised patients.</p>Fórmula:C37H42F2N8O4Pureza:Min. 98 Area-%Forma y color:PowderPeso molecular:700.78 g/molPosaconazole - Form I
CAS:<p>Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.</p>Fórmula:C37H42F2N8O4Pureza:Min. 95%Peso molecular:700.78 g/molPosaconazole
CAS:<p>Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.</p>Fórmula:C37H42F2N8O4Pureza:Min. 98 Area-%Forma y color:White PowderPeso molecular:700.78 g/molPosaconazole - Form III
CAS:<p>Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.</p>Fórmula:C37H42F2N8O4Pureza:Min. 95%Peso molecular:700.78 g/molPosaconazole Monodesfluoro
CAS:Producto controladoFórmula:C21H22FN3O4SForma y color:NeatPeso molecular:431.481Posaconazole (Ethyl-d5)
CAS:Producto controladoFórmula:C37D5H37F2N8O4Forma y color:NeatPeso molecular:705.808
![4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0039KV.jpg&w=3840&q=75)
