CAS 171436-38-7

H-SER-LEU-ILE-GLY-ARG-LEU-NH2

Descripción:

La sustancia química identificada como H-SER-LEU-ILE-GLY-ARG-LEU-NH2, con el número CAS 171436-38-7, es un péptido compuesto por una secuencia específica de aminoácidos: serina (Ser), leucina (Leu), isoleucina (Ile), glicina (Gly), arginina (Arg) y otra leucina (Leu). Este péptido presenta una modificación en el extremo N-terminal (indicado por "H-") y un grupo amida en el extremo C-terminal (indicado por "NH2"), lo que puede influir en su estabilidad y actividad biológica. Los péptidos como este a menudo se estudian por sus roles en procesos biológicos, incluyendo señalización, actividad enzimática y como agentes terapéuticos potenciales. La presencia de aminoácidos tanto hidrofóbicos (Leu, Ile) como polares (Ser, Gly) sugiere que el péptido puede tener interacciones diversas en sistemas biológicos. Además, el residuo de arginina puede contribuir a la carga positiva y a posibles interacciones de unión con moléculas cargadas negativamente. En general, las características de este péptido lo convierten en un tema de interés en bioquímica y farmacología.

Fórmula: C₂₉H₅₆N₁₀O₇

Sinónimos:

• Ser-Leu-Ile-Gly-Arg-Leu-Amide
• Sligrlamide
• Sligrl-Nh2
• Thrombin Receptor-Like 1 (1-6) Amide (Mouse, Rat)
• Proteinase Activated Receptor 2 (1-6) Amide (Mouse, Rat)
• Proline/Betaine Transporter Fragment Amide
• Par-2 (1-6) Amide (Mouse, Rat)
• Par2-Ap

PAR-2 (1-6) amide (mouse, rat)

CAS: 171436-38-7

SLIGRL-amide, protease-activated receptor-2 (PAR2) selective agonist. The reverted PAR2 peptide can be used as inactive control.

Fórmula: C₂₉H₅₆N₁₀O₇

Pureza: 99.4%

Forma y color: White

Peso molecular: 656.83

Ref: 01-4033483

SLIGRL-NH2

CAS: 171436-38-7

SLIGRL-NH2

Pureza: ≥98%

Peso molecular: 656.82g/mol

Ref: 54-BUP21798

SLIGRL-NH2

CAS: 171436-38-7

SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a PAR-2 agonist that induces non-histaminergic pruritus.

Fórmula: C₂₉H₅₆N₁₀O₇

Pureza: 98.29%

Forma y color: Solid

Peso molecular: 656.82

Ref: TM-TP1046

PAR-2 (1-6) (mouse, rat)

CAS: 171436-38-7

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Fórmula: C₂₉H₅₆N₁₀O₇

Peso molecular: 656.83 g/mol

Ref: 3D-PP50110

H-Ser-Leu-Ile-Gly-Arg-Leu-NH2

CAS: 171436-38-7

H-Ser-Leu-Ile-Gly-Arg-Leu-NH2 is a cyclase inhibitor that binds to the neurokinin 1 receptor, leading to an inhibition of the release of inflammatory substances in the bowel. HSLIGRL can also inhibit epidermal growth factor (EGF), which suppresses inflammation and cell proliferation. HSLIGRL also inhibits inflammatory bowel disease by decreasing the production of prostaglandins, which are chemical messengers involved in pain and inflammation. HSLIGRL has been shown to be effective against low potency benzalkonium chloride, which is often used as a preservative in pharmaceuticals. This compound has been shown to reduce inflammation by inhibiting proinflammatory cytokines such as TNFα and IL1β.

Fórmula: C₂₉H₅₆N₁₀O₇

Pureza: Min. 95%

Peso molecular: 656.83 g/mol

Ref: 3D-PAR-3664-PI

PAR-2 (1-6) amide (mouse, rat)

CAS: 171436-38-7

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Fórmula: C₂₉H₅₆N₁₀O₇

Peso molecular: 656.83 g/mol

Ref: 3D-PP50028

SLIGRL-NH2

CAS: 171436-38-7

Fórmula: C₂₉H₅₆N₁₀O₇

Pureza: 95%

Forma y color: Solid

Peso molecular: 656.83

Ref: 10-F047237

SL-NH2 Trifluoroacetic Acid Salt (1:2)

Producto controlado

CAS: 171436-38-7

Applications SL-NH2 Trifluoroacetic Acid Salt (1:2), is a PAR2 acute agonist which causes hyperglasia, or an increase to the sensitivity to pain.
References Huang, Z. et al.; Brain Res., 1425, 20 (2011);

Fórmula: C₂₉H₅₆N₁₀O₇•2(C₂HF₃O₂)

Forma y color: Neat

Peso molecular: 656.82211402

Ref: TR-S560005

PAR-2 (1-6) amide (mouse, rat) trifluoroacetate salt

CAS: 171436-38-7

PAR-2 agonist is a synthetic peptide that activates PAR-2. It binds to PAR-2 receptors, which are present in the mesenteric vasculature and in various other tissues. Activation of PAR-2 leads to an increase in intracellular calcium concentration, activation of protein kinase C, cytosolic calcium ion release, phosphorylation of myosin light chain, muscle cell proliferation, transcription and translation initiation, and increased production of vasoactive intestinal peptide. This drug also has anti-inflammatory effects and stimulates epidermal growth factor (EGF) and thrombin receptor expression as well as growth factor production.

Fórmula: C₂₉H₅₆N₁₀O₇

Pureza: Min. 95%

Peso molecular: 656.82 g/mol

Ref: 3D-FP109453