CAS 17575-22-3

lanatósido C

Descripción:

lanatósido C es un glucósido cardíaco, un tipo de compuesto que ejerce un efecto inotrópico positivo, lo que significa que aumenta la fuerza de las contracciones del corazón. Se deriva de la planta Digitalis lanata, comúnmente conocida como dedalera lanosa. Este compuesto se caracteriza por su estructura compleja, que incluye un núcleo esteroide y un componente de azúcar, contribuyendo a su actividad biológica. lanatósido C es conocido por su capacidad para inhibir la enzima Na+/K+ ATPasa, lo que lleva a un aumento en los niveles de calcio intracelular, lo que mejora la contractilidad cardíaca. Se utiliza típicamente en el tratamiento de la insuficiencia cardíaca y ciertas arritmias. El compuesto también es notable por su índice terapéutico relativamente bajo, lo que requiere un monitoreo cuidadoso de la dosis para evitar la toxicidad. En términos de solubilidad, lanatósido C es generalmente soluble en disolventes orgánicos, pero tiene una solubilidad limitada en agua. Su farmacocinética puede verse influenciada por factores como la edad del paciente, la función renal y los medicamentos concurrentes, lo que hace que los enfoques de tratamiento individualizados sean esenciales.

Fórmula: C₄₉H₇₆O₂₀

InChI: InChI=1/C49H76O20/c1-21-43(67-38-17-32(53)44(22(2)62-38)68-39-18-33(64-24(4)51)45(23(3)63-39)69-46-42(58)41(57)40(56)34(19-50)66-46)31(52)16-37(61-21)65-27-9-11-47(5)26(14-27)7-8-29-30(47)15-35(54)48(6)28(10-12-49(29,48)59)25-13-36(55)60-20-25/h13,21-23,26-35,37-46,50,52-54,56-59H,7-12,14-20H2,1-6H3/t21-,22-,23-,26?,27+,28-,29?,30?,31+,32+,33+,34-,35-,37+,38+,39+,40-,41+,42-,43-,44-,45-,46+,47+,48+,49+/m1/s1

Clave InChI: InChIKey=JAYAGJDXJIDEKI-PTGWOZRBSA-N

SMILES: O[C@@]12[C@@](C)([C@H](CC1)C=3COC(=O)C3)[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](OC(C)=O)[C@H](O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6)C5)[H])[H])[H]

Sinónimos:

• (3beta,5beta,12beta)-3-{[beta-D-glucopyranosyl-(1->4)-3-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3beta,5beta,9xi,12beta)-3-{[hexopyranosyl-(1->4)-3-O-acetyl-2,6-dideoxyhexopyranosyl-(1->4)-2,6-dideoxyhexopyranosyl-(1->4)-2,6-dideoxyhexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3beta,8xi,9xi,12beta)-3-{[beta-D-glucopyranosyl-(1->4)-3-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3β,5β,12β)-3-[(O-β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• 3-((O beta-D-Glucopyranosyl-(1-4)-O-3beta-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12beta,14-dihydroxy-5beta-card-20(22)-enolide
• 3-{[hexopyranosyl-(1->4)-3-O-acetyl-2,6-dideoxyhexopyranosyl-(1->4)-2,6-dideoxyhexopyranosyl-(1->4)-2,6-dideoxyhexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• Allocor
• Card-20(22)-enolide, 3-((O-beta-D-glucopyranosyl-(1-4)-O-3-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)- (9CI)
• Card-20(22)-enolide, 3-[(O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Cedilanid
• Ceglunat
• Ceglunate
• Celadigal
• Celanid
• Celanide
• Celanidum
• Cetosanol
• Desacetyllanatoside
• Digilanid C
• Digilanide C
• Digilanogen C
• Glycoside obtained from the leaves of Digitalis lanata Ehrh
• Isolanid
• Isolanide
• Lanatigen C
• Lanatosid C
• Lanatosid C [German]
• Lanatoside C [INN:BAN:DCF:JAN]
• Lanatosido C
• Lanatosido C [INN-Spanish]
• Lanatosidum C
• Lanatosidum C [INN-Latin]
• Lanimerck
• Lanocide-C
• NSC 7533
• Nsc 119991
• (3β,5β,12β)-3-[(O-β-D-Glucopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• Card-20(22)-enolide, 3-[(O-β-D-glucopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Lanatoside C
• Lanatoside C
• Digoxin EP Impurity H
• digilanidec
• Card-20(22)-enolide, 3-[(O-b-D-glucopyranosyl-(14)-O-3-O-acetyl-2,6-dideoxy-b-D-ribo-hexopyranosyl-(14)-O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(14)-2,6-dideoxy-b-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3b,5b,12b)- (9CI)
• LANATOSIDE C WHO(CRM STANDARD)
• (3β,5β,12β)-
• Digoxin EP Impurity H (Lanatoside C)
• 20(22),5BETA-CARDENOLID-3BETA,12BETA,14BETA-TRIOL 3BETA-O-BETA-D-GLUCOPYRANOSYL-(1->4)-O-BETA-D-[3-O-ACETYLDIGITOXOPYRANOSYL]-(1->4)-O-BETA-D-DIGITOXOPYRANOSIDE-(1->4)-O-BETA-D-DIGITOXOPYRANOSIDE
• Digoxin Impurity 8(Digoxin EP Impurity H)
• Trigonin C (digoxin impurity H)
• Card-20(22)-enolide, 3-[(o-.beta.-D-glucopyranosyl-(1.fwdarw.4)-o-3-o-acetyl-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1.fwdarw.4)-o-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1.fwdarw.4)-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3.beta.,5.beta.,12.beta.)-
• Lanatoside C (Digoxin Impurity H)
• LANATOSIDE C 97%
• LANATOSIDE C USP/EP/BP
• LANATOSIDE C(REAGENT / STANDARD GRADE)

Lanatoside C

CAS: 17575-22-3

Lanatoside C analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Fórmula: C₄₉H₇₆O₂₀

Pureza: (HPLC) ≥95%

Forma y color: Powder

Peso molecular: 985.14

Ref: 11-0817

Card-20(22)-enolide, 3-[(O-β-D-glucopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-

CAS: 17575-22-3

Fórmula: C₄₉H₇₆O₂₀

Pureza: 98%

Forma y color: Solid

Peso molecular: 985.1157

Ref: IN-DA002164

Digoxin EP Impurity H (Lanatoside C)

CAS: 17575-22-3

Fórmula: C₄₉H₇₆O₂₀

Forma y color: White To Off-White Solid

Peso molecular: 985.13

Ref: 4Z-D-7512

Lanatoside C

CAS: 17575-22-3

Lanatoside C

Pureza: ≥98%

Peso molecular: 985.12g/mol

Ref: 54-BUP00123

Lanatoside C

CAS: 17575-22-3

Fórmula: C₄₉H₇₆O₂₀

Pureza: ≥ 95.0%

Forma y color: White to off-white powder

Peso molecular: 985.12

Ref: 7W-GC7353

Lanatoside C

CAS: 17575-22-3

Fórmula: C₄₉H₇₆O₂₀

Pureza: 95%~99%

Peso molecular: 985.127

Ref: BP-BP0838

Lanatoside C

CAS: 17575-22-3

Lanatoside C, a cardiac glycoside, treats heart failure and arrhythmia; taken orally or IV.

Fórmula: C₄₉H₇₆O₂₀

Pureza: 98.3% - >99.99%

Forma y color: Solid

Peso molecular: 985.12

Ref: TM-T1670

Lanatoside c

CAS: 17575-22-3

Digitalis glycoside

Fórmula: C₄₉H₇₆O₂₀

Pureza: ≥ 98.0 % (HPLC)

Forma y color: Powder

Peso molecular: 985.13

Ref: 5G-82573

Lanatoside C

CAS: 17575-22-3

Stability Hygroscopic
Applications Glycosides isolated from various species of Digitalis. Cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Novotny, J., et al.: J. Biol. Chem., 258, 14433 (1983), Farr, C., et al.: J. Med. Chem., 45, 3257 (2002), Van Dongen, M., et al.: Drug Discov. Today, 7, 471 (2002),

Fórmula: C₄₉H₇₆O₂₀

Forma y color: White To Off-White

Peso molecular: 985.12

Ref: TR-L173800

Lanatoside C

CAS: 17575-22-3

Lanatoside C is a cardiac glycoside, which is a bioactive compound derived from the leaves of the plant Digitalis lanata. This compound exerts its effects primarily through inhibition of the Na⁺/K⁺-ATPase enzyme in cardiac muscle cells. By inhibiting this enzyme, Lanatoside C increases intracellular sodium levels, which indirectly leads to an increase in intracellular calcium via the sodium-calcium exchange mechanism. The elevated calcium concentrations enhance cardiac muscle contraction, thereby improving cardiac output and efficiency.

Fórmula: C₄₉H₇₆O₂₀

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 985.12 g/mol

Ref: 3D-OL09899

Digoxin EP Impurity H

CAS: 17575-22-3

Fórmula: C₄₉H₇₆O₂₀

Peso molecular: 985.1

Ref: ST-EA-CP-D1200007