CAS 1775-97-9

Flavokawain B

Descripción:

Flavokawain B es un compuesto natural clasificado como flavokawain, que es un tipo de chalcona. Se deriva principalmente de la especie de planta *Kava* (Piper methysticum), conocida por su uso tradicional en varias culturas por sus propiedades psicoactivas. La estructura química de Flavokawain B presenta un esqueleto de chalcona característico, que consiste en dos anillos aromáticos conectados por un sistema carbonílico α,β-insaturado de tres carbonos. Este compuesto exhibe una variedad de actividades biológicas, incluyendo propiedades antiinflamatorias, antioxidantes y potenciales anticancerígenas, lo que lo convierte en un tema de interés en la investigación farmacológica. Flavokawain B también se destaca por su capacidad para modular diversas vías celulares, lo que puede contribuir a sus efectos terapéuticos. Su solubilidad y estabilidad pueden variar dependiendo del disolvente y las condiciones ambientales, influyendo en su biodisponibilidad y eficacia en sistemas biológicos. Al igual que muchos compuestos naturales, se necesitan más estudios para elucidar completamente sus mecanismos de acción y aplicaciones potenciales en medicina.

Fórmula: C₁₇H₁₆O₄

InChI: InChI=1S/C17H16O4/c1-20-13-10-15(19)17(16(11-13)21-2)14(18)9-8-12-6-4-3-5-7-12/h3-11,19H,1-2H3/b9-8+

Clave InChI: InChIKey=QKQLSQLKXBHUSO-CMDGGOBGSA-N

SMILES: C(/C=C/C1=CC=CC=C1)(=O)C2=C(OC)C=C(OC)C=C2O

Sinónimos:

• (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one
• (2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
• (E)-1-(2-Hydroxy-4,6-Dimethoxy-Phenyl)-3-Phenyl-Propenone
• (E)-1-(2-Hydroxy-4,6-dimethoxy-phenyl)-3-phenyl-
• (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
• (E)-2′-Hydroxy-4′,6′-dimethoxychalcone
• 1-(2-Hydroxy-4,6-Dimethoxyphenyl)-3-Phenyl-2-Propen-1-One)
• 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)-
• 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (E)-
• Cardamonin-4'-Methyl Ether
• Chalcone, 2′-hydroxy-4′,6′-dimethoxy-
• Dimethoxy-2'-Hydroxychalcone, 4',6'-
• Flavokavain B
• Flavokavin B
• Flavokawain B
• Flavokawin B

Flavokawain B

CAS: 1775-97-9

Flavokawain B analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Fórmula: C₁₇H₁₆O₄

Pureza: (HPLC) ≥95%

Forma y color: Powder

Peso molecular: 284.31

Ref: 11-1045

2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)-

CAS: 1775-97-9

Fórmula: C₁₇H₁₆O₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 284.3065

Ref: IN-DA0025DP

Flavokawain B

CAS: 1775-97-9

Fórmula: C₁₇H₁₆O₄

Peso molecular: 284.31

Ref: 7W-GY4305

Flavokawain B

CAS: 1775-97-9

Flavokawain B

Pureza: ≥98%

Peso molecular: 284.31g/mol

Ref: 54-BUP00989

Flavokawain B

CAS: 1775-97-9

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. Flavokawain B has potent anti-inflammatory, and anti-cancer activities, it can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

Fórmula: C₁₇H₁₆O₄

Pureza: 95%~99%

Forma y color: Yellow powder

Peso molecular: 284.311

Ref: BP-BP3146

Flavokawain B

CAS: 1775-97-9

Flavokawain B inhibits NO and PGE2, causes oxidative stress, and induces apoptosis, with potential for treating prostate cancer.

Fórmula: C₁₇H₁₆O₄

Pureza: 99.97% - >99.99%

Forma y color: Solid

Peso molecular: 284.31

Ref: TM-T6S0735

Flavokawain b

CAS: 1775-97-9

Ketone phenol

Fórmula: C₁₇H₁₆O₄

Pureza: ≥ 98.0 % (HPLC)

Forma y color: Powder

Peso molecular: 284.31

Ref: 5G-83763

Flavokavain B

Producto controlado

CAS: 1775-97-9

Applications Flavokavain B is a secondary metabolite of the kava plant (Piper methysticum Forst. f., Piperaceae, which has anticancer properties and demonstrated oral efficacy in murine cancer models.  Futhermore, it also has suspected roles in rare cases of kava-induced hepatotoxicity. In addition, it is a potential candidate for the development of novel antifungal phytotherapic products.
References Pinner, K. D., et al.: Pharmaceutical Biology (Abingdon, United Kingdom), 54, Epub ahead of print (2016); Rowe A., et al.: Phytotherapy Research, 26, 1768 (2012); Alves dos Santos, R., et al.: Journal of Chemistry, (2013)

Fórmula: C₁₇H₁₆O₄

Forma y color: Yellow To Dark Yellow

Peso molecular: 284.31

Ref: TR-F371025

4',6'-Dimethoxy-2'-hydroxychalcone

CAS: 1775-97-9

4',6'-Dimethoxy-2'-hydroxychalcone is a chalcone compound, which is a type of flavonoid. Flavonoids are polyphenolic compounds synthesized by plants. This particular compound is typically derived from various plant sources, where it plays a role in the plant's defense mechanisms. As a chalcone, it contains a characteristic open-chain framework that distinguishes it from other flavonoids.

Fórmula: C₁₇H₁₆O₄

Pureza: Min. 95%

Peso molecular: 284.31 g/mol

Ref: 3D-FD66669