CAS 177943-89-4

4,7,10-tricarboximetil-1,4,7,10-tetraaza-ciclododecan-1-il-acetil-D-phe-cis-tir-D-trp-lis-tre-cis-tre-OH, (enlace disulfuro) acetato

Descripción:

4,7,10-Tricarboximetil-1,4,7,10-tetraaza-ciclododecano-1-il-acetil-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-OH, con el número CAS 177943-89-4, es un compuesto químico complejo caracterizado por su estructura única que incluye un anillo de ciclododecano, múltiples grupos carboximetilo y una secuencia peptídica que presenta varios aminoácidos. La presencia de enlaces disulfuro indica que puede formar uniones estables entre residuos de cisteína, contribuyendo a su integridad estructural y potencial actividad biológica. Este compuesto probablemente exhiba propiedades como solubilidad en disolventes polares debido a sus grupos ácidos carboxílicos y puede interactuar con sistemas biológicos, lo que lo hace de interés en campos como la química medicinal y la bioquímica. Su estructura intrincada sugiere aplicaciones potenciales en la entrega de fármacos o como agente terapéutico, particularmente en la orientación a vías biológicas específicas. La forma acetato indica que puede ser más soluble o estable en ciertas condiciones, mejorando su usabilidad en diversas aplicaciones químicas y biológicas.

Fórmula: C₆₅H₉₀N₁₄O₁₉S₂

Sinónimos:

• Dota-(Tyr3)-Octreotate Acetate
• Dota-(Tyr3,Thr8)-Octreotide Acetate
• DOTA-[Tyr3]-Octreotate, DOTA-[Tyr3, Thr8]-Octreotide, DOTA-TATE
• N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraaza-cyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-trypto-phyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic(2-7) disulfide

DOTA-(Tyr³)-Octreotate

CAS: 177943-89-4

DOTA-conjugated somatostatin analog for labeling with radiometals such as gallium-67 or gallium-68, indium-111, and yttrium-90. DOTA-TATE is a useful tool in receptor-mediated tumor imaging and peptide receptor-targeted radionuclide therapy. CAS-Number (net): 177943-88-3.

Fórmula: C₆₅H₉₀N₁₄O₁₉S₂

Pureza: 97.5%

Forma y color: White Powder

Peso molecular: 1435.65

Ref: 01-4046724

DOTATATE acetate

CAS: 177943-89-4

DOTATATE acetate is a DOTA-binding peptide involved in the assessment of functional imaging of highly differentiated neuroendocrine tumors (NETs).

Fórmula: C₆₀H₉₀N₁₄O₁₉S₂xC₂H₄O₂

Pureza: 98.70%

Forma y color: Solid

Ref: TM-T39193

DOTA-(Tyr3)-Octreotate acetate salt

CAS: 177943-89-4

Fórmula: C₆₇H₉₄N₁₄O₂₁S₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 1495.6745

Ref: IN-DA0025N0

DOTATATE acetate

CAS: 177943-89-4

DOTATATE acetate

Pureza: ≥98%

Ref: 54-BUP00780

DOTA-(Tyr3)-Octreotate acetate salt

Producto controlado

CAS: 177943-89-4

Octreotate is a radiopharmaceutical that is synthesized by reacting DOTA-Tyr3 with octreotide acetate. Octreotate, also known as dotatate, is used in nuclear medicine to treat neuroendocrine tumours. This drug has a high yield and can be reliably prepared using cassettes and computerised equipment to create germanium-68 labelled octreotate. The radionuclide emits positrons and gamma rays, which are used for imaging neuroendocrine tumours in the brain or other organs. Octreotate is a synthetic analogue of the natural hormone octreotide, which binds to receptors on the cell surface and prevents the release of hormones from cells. This may be due to its ability to inhibit protein synthesis by inhibiting rRNA synthesis.

Fórmula: C₆₅H₉₀N₁₄O₁₉S₂

Pureza: Min. 95 Area-%

Forma y color: White Slightly Yellow Powder

Peso molecular: 1,435.63 g/mol

Ref: 3D-FD109795

DOTA-(Tyr3)-octreotate Acetate Salt

Producto controlado

CAS: 177943-89-4

Stability Hygroscopic
Applications DOTA-​(Tyr3)​-​octreotate can be obtained through preparation of DOTA-containing peptides and radionucleotide complexes as antitumor agents for treating somatostatin postive tumor and metastasized tumors.
References Albert, R., et al.: Jpn. Kokai Tokkyo Koho, JP 08081498 A 19960326 (1996)

Fórmula: C₆₅H₉₀N₁₄O₁₉S₂·xCH₃COOH

Forma y color: Neat

Peso molecular: 1495.68

Ref: TR-D535760