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CAS 1782228-59-4

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  • NBI 35965 hydrochloride
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    NBI 35965 hydrochloride

    CAS:
    <p>NBI 35965 hydrochloride is a selective CRF1 (corticotropin-releasing factor receptor 1) antagonist that is both orally active and capable of penetrating the brain. It possesses a K i value of 4 nM and a pK i of 8.5, and does not affect CRF2. This compound effectively diminishes CRF or stress-triggered ACTH (adrenocorticotropic hormone) production in vivo, demonstrating pIC 50 values of 7.1 and 6.9. Additionally, NBI 35965 hydrochloride exhibits anxiolytic properties [1] [2].</p>
    Fórmula:C21H23Cl3N4
    Forma y color:Solid
    Peso molecular:437.79

    Ref: TM-T86978