CAS 179324-69-7

Bortezomib

Descripción:

Bortezomib es un inhibidor del proteasoma utilizado principalmente en el tratamiento del mieloma múltiple y ciertos tipos de linfoma. Es un compuesto sintético que pertenece a la clase de los derivados del ácido bórico. La fórmula química de Bortezomib es C19H25BoroN4O4, y presenta un átomo de boro que juega un papel crucial en su mecanismo de acción, que implica la inhibición del proteasoma, un complejo celular responsable de degradar proteínas ubiquitinadas. Esta inhibición conduce a la acumulación de factores pro-apoptóticos y reguladores del ciclo celular, induciendo finalmente la apoptosis en las células cancerosas. Bortezomib se administra por inyección intravenosa o subcutánea y es conocido por sus efectos secundarios, que pueden incluir neuropatía periférica, problemas gastrointestinales y toxicidades hematológicas. Su farmacocinética implica una rápida absorción y distribución, con una vida media que permite esquemas de dosificación efectivos. En general, Bortezomib representa un avance significativo en la terapia dirigida contra el cáncer, mostrando el potencial de las pequeñas moléculas en el tratamiento de malignidades hematológicas.

Fórmula: C₁₉H₂₅BN₄O₄

InChI: InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1

Clave InChI: InChIKey=GXJABQQUPOEUTA-RDJZCZTQSA-N

SMILES: [C@H](CC1=CC=CC=C1)(C(N[C@@H](CC(C)C)B(O)O)=O)NC(=O)C=2C=NC=CN2

Sinónimos:

• B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
• Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-
• Boronic acid, [(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-
• Boronic acid, [3-methyl-1-[[1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-, [S-(R*,S*)]-
• Bortezomib for research
• Bortizomib
• Brotezamide
• Dpba
• Ldp 341
• Mg 341
• Mln 341
• N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
• N-[(1S)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-D-phenylalaninamide
• NSC 681239
• PS 341 (pharmaceutical)
• Ps 314
• Ps 341
• Radiciol
• Velcade

Bortezomib

CAS: 179324-69-7

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 384.24

Ref: 3B-B5741

Bortezomib, 98%

CAS: 179324-69-7

Bortezomib, 179324-69-7, is a peptidic boronic acid analog and antineoplastic agent which turns off cell signaling pathways through 26S proteasome inhibition. Learn more.

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: 98%

Forma y color: Powder or crystals or crystalline powder, White to off-white

Peso molecular: 384.24

Ref: 02-J60378

Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-

CAS: 179324-69-7

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 384.2372

Ref: IN-DA0026XG

Bortezomib

CAS: 179324-69-7

Bortezomib

Pureza: ≥95%

Peso molecular: 384.24g/mol

Ref: 54-BUP15505

Bortezomib

CAS: 179324-69-7

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: ≥ 98.0%

Forma y color: White to off-white powder or solid

Peso molecular: 384.24

Ref: 7W-GP0262

Bortezomib

CAS: 179324-69-7

Bortezomib

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: 98% (nmr) (Typical Value in Batch COA)

Forma y color: white solid

Peso molecular: 384.24g/mol

Ref: 54-BISN0125

Bortezomib

CAS: 179324-69-7

Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: 97.79% - >99.99%

Forma y color: Yellow Solid

Peso molecular: 384.24

Ref: TM-T2399

(1R,2S)-Bortezomib

CAS: 179324-69-7

Fórmula: C₁₉H₂₅BN₄O₄

Peso molecular: 384.24

Ref: 4Z-B-4697

Bortezomib-D8 (Major)

Producto controlado

CAS: 179324-69-7

Applications Labelled Bortezomib, which the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells.d6-3%d7-10%d8-86%
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005)

Fórmula: C₁₉H₁₇D₈BN₄O₄

Forma y color: Off-White

Peso molecular: 392.29

Ref: TR-B675702

Bortezomib

Producto controlado

CAS: 179324-69-7

Stability Hygroscopic and Moisture Sensitive
Applications Bortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009);

Fórmula: C₁₉H₂₅BN₄O₄

Forma y color: White To Off-White

Peso molecular: 384.24

Ref: TR-B675700

Bortezomib - Bio-X ™

CAS: 179324-69-7

Bortezomib is a selective and reversible inhibitor of the multicatalytic 26S proteasome. The inhibition of protein breakdown affects several metabolic pathways and leads to cell death. The compound is effective in treating t-cell lymphomas and multiple myeloma because it prevents the binding of myeloma cells to bone marrow stroma and inhibits osteoclast differentiation.

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 384.24 g/mol

Ref: 3D-BB164258

Bortezomib

CAS: 179324-69-7

Selective and reversible inhibitor of the multicatalytic 26S proteasome. The inhibition of protein breakdown affects several metabolic pathways and leads to cell death. The compound is effective in treating multiple myeloma because it prevents the binding of myeloma cells to bone marrow stroma and inhibits osteoclast differentiation.

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 384.24 g/mol

Ref: 3D-FM19000

Bortezomib

CAS: 179324-69-7

Pureza: 98%

Peso molecular: 384.24

Ref: 10-M06307