CAS 179463-17-3

Cancidas

Descripción:

Cancidas, con el número CAS 179463-17-3, es el nombre comercial del agente antifúngico caspofungina. Pertenece a la clase de antifúngicos llamados equinocandinas, que son conocidas por su mecanismo de acción que inhibe la síntesis de β-(1,3)-D-glucano, un componente esencial de la pared celular fúngica. Esta interrupción conduce a la lisis celular y a la muerte del hongo. La caspofungina se utiliza principalmente para tratar infecciones fúngicas invasivas, particularmente aquellas causadas por especies de Candida y Aspergillus, especialmente en pacientes inmunocomprometidos. Se administra por vía intravenosa y se caracteriza por su perfil de toxicidad relativamente bajo en comparación con otros agentes antifúngicos. El fármaco es generalmente bien tolerado, con efectos secundarios que pueden incluir fiebre, erupción cutánea y trastornos gastrointestinales. Su farmacocinética implica una vida media de eliminación lenta, lo que permite una dosificación una vez al día. En general, Cancidas representa una opción crítica en el manejo de infecciones fúngicas graves, particularmente en pacientes que son resistentes a otras terapias antifúngicas.

Fórmula: C₅₆H₉₆N₁₀O₁₉

InChI: InChI=1/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72;2*1-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75);2*1H3,(H,3,4)/t28?,29?,30-,33-,34-,35+,36-,37+,38-,40+,41+,42+,43?,44+,45+,46+;;/m1../s1

Sinónimos:

• Caspofungin acetate
• (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate
• N-{(2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide
• N-{(2R,6S,9S,11R,12R,14aS,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1S)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide acetate (1:2)
• N-{(2R,6S,9R,11R,12S,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide acetate (1:2)
• Cancidas (Caspofungin Acetate)

Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2)

CAS: 179463-17-3

Fórmula: C₅₄H₉₂N₁₀O₁₇

Pureza: 98%

Forma y color: Solid

Peso molecular: 1153.3651

Ref: IN-DA002711

Caspofungin Diacetate

CAS: 179463-17-3

Fórmula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Forma y color: White To Off-White Solid

Peso molecular: 1093.34 2*60.05

Ref: 4Z-PC-155001

Caspofungin Acetate

CAS: 179463-17-3

Caspofungin Acetate

Pureza: ≥95%

Peso molecular: 1213.42g/mol

Ref: 54-BUP06070

Caspofungin acetate

CAS: 179463-17-3

Fórmula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Pureza: (HPLC) ≥ 97.0% (anhydrous basis)

Forma y color: White to off-white powder

Peso molecular: 1213.42

Ref: 7W-GP8659

Caspofungin Acetate

CAS: 179463-17-3

Caspofungin Acetate (MK 0991) is the acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the

Fórmula: C₅₆H₉₆N₁₀O₁₉

Pureza: 97.94% - 99.9%

Forma y color: White Powder

Peso molecular: 1213.42

Ref: TM-T1799

Caspofungin Acetate

CAS: 179463-17-3

Applications An echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.
References Sandhu, P. et al.: Antimicrob. Agents Chemorther., 48, 1272 (2004); Bertsche, T. et al.: Pharamaz. Zeit., 148, 34 (2003); Hoang, A.: Am. J. Health-Sys. Pharm., 58, 1206 (2001);

Fórmula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Pureza: >90%

Forma y color: White To Light Yellow

Peso molecular: 1213.42

Ref: TR-C184900

Caspofungin acetate

Producto controlado

CAS: 179463-17-3

Inhibitor of glucan synthase; antifungal compound

Fórmula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Pureza: Min. 90 Area-%

Forma y color: Powder

Peso molecular: 1,213.42 g/mol

Ref: 3D-FC16269

Caspofungin acetate - Bio-X ™

Producto controlado

CAS: 179463-17-3

Caspofungin is an echinocandin that belongs to the class of antifungal agents. It is used to treat Aspergillus and Candida infections. It works by inhibiting the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of Aspergillus species and Candida species.

Fórmula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 1,213.42 g/mol

Ref: 3D-BC164293