CAS 181183-52-8
:Almotriptán malato
Descripción:
Almotriptán malato es un compuesto farmacéutico utilizado principalmente en el tratamiento de las migrañas. Pertenece a la clase de medicamentos triptanes, que están diseñados específicamente para aliviar los síntomas de la migraña actuando como agonistas en los receptores de serotonina, particularmente en los subtipos 5-HT_1B y 5-HT_1D. Esta acción conduce a la vasoconstricción de los vasos sanguíneos craneales y a la inhibición de la liberación de neuropeptidos proinflamatorios. El almotriptán se caracteriza por su relativamente alta biodisponibilidad oral y un perfil farmacocinético favorable, que incluye una vida media moderada que permite un manejo efectivo de los ataques agudos de migraña. La forma de sal de malato mejora su solubilidad y estabilidad, facilitando la absorción en el tracto gastrointestinal. El almotriptán generalmente es bien tolerado, aunque puede causar efectos secundarios como mareos, fatiga o sensaciones de hormigueo. Al igual que otros triptanes, está contraindicado en pacientes con ciertas condiciones cardiovasculares debido al potencial de vasoconstricción. En general, Almotriptán malato representa una opción importante en el arsenal terapéutico para el manejo de la migraña.
Fórmula:C17H25N3O2S·C4H6O5
InChI:InChI=1/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)
Clave InChI:InChIKey=QHATUKWEVNMHRY-UHFFFAOYSA-N
SMILES:C(CN(C)C)C=1C=2C(NC1)=CC=C(CS(=O)(=O)N3CCCC3)C2.C(CC(O)=O)(C(O)=O)O
Sinónimos:- 1-[[3-(2-Dimethylaminoethyl)-5-Indolyl]Methanesulphonyl]Pyrrolidine Malate
- 1-[[[2-(Dimethyl-Amino)Ethyl]-1H-Indol-5-Yl]Methyl]Sulfonyl]Pyrrolidine Malate
- 2-hydroxybutanedioic acid - N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (1:1)
- Almotrip forte
- Almotriptan Malate
- Almotriptan Maleate
- Almotriptanmaleate
- Axert
- Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
- Butanedioic acid, hydroxy-, compd with 1-[[[3-[2-(dimethylamino)ethyl]-1h-indol-5-yl]methyl]sulfonyl]pyrrolidine
- Butanedioic acid, hydroxy-, compd. with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine (1:1)
- LAS 31416 <span class="text-smallcaps">D</smallcap>,<smallcap>L</span>-malate acid
- Las-31416 Malate
- N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine
- Pnu 180638
- Pnu 180638E
- Pyrrolidine, 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]-, hydroxybutanedioate (1:1)
- LAS 31416 D,L-malate acid
- hydroxy-Butanedioic acid, compd.with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine(1:1)(9CI)
- N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine,compd. with 2-hydroxy-butanedioic acid
- Almotriptan
- AlMotriptan Malate (Axert)
- Amotriptan malate
- 1-[[[3-[2-(dimeth
- See: A575201
- 2-Hydroxy-butanedioic acid, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
- Almotriptan Malate (200 mg)
- Ver más sinónimos
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Encontrado 13 productos.
Almotriptan Malate
CAS:Sulfonamides used as drugsFórmula:C17H25N3O2S·C4H6O5Forma y color:White Off-White Crystalline PowderPeso molecular:335.16675Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
CAS:Fórmula:C21H31N3O7SPureza:98%Forma y color:SolidPeso molecular:469.5517Almotriptan-d6 Malate
CAS:Fórmula:C17H19D6N3O2S·C4H6O5Forma y color:White To Off-White SolidPeso molecular:341.50 134.09Almotriptan Malate
CAS:Fórmula:C17H25N3O2S·C4H6O5Forma y color:Pale Yellow SolidPeso molecular:335.47 134.09Almotriptan Malate
CAS:Fórmula:C17H25N3O2S·C4H6O5Pureza:>98.0%(HPLC)Forma y color:White to Orange to Green powder to crystalPeso molecular:469.55Almotriptan Malate
CAS:<p>Almotriptan Malate (PNU180638), a selective 5-HT1B/1D receptor agonist, is used in the therapy of Migraine attacks in adults.</p>Fórmula:C17H25N3O2S·C4H6O5Pureza:99.95%Forma y color:Pale Yellow SolidPeso molecular:469.55Almotriptan malate
CAS:<p>Almotriptan malate is a serotonin 1B/1D receptor agonist that is used as an anti-migraine drug, specifically for the treatment of migraine headaches with or without aura. It has been shown to cause regression of angiogenic factors and statistically significant improvement in migraine headache frequency, severity, and duration when taken within 24 hours of onset of a migraine. Almotriptan malate can be administered by nasal spray or oral tablets. The recommended dose for adults is 25-50 mg (1-2 tablets) taken at the first sign of a headache. Almotriptan malate should not be given to people who have liver impairment or are taking sodium carbonate. Side effects may include nasal congestion, dizziness, dry mouth, nausea, vomiting, and diarrhea. Almotriptan malate should be used with caution in patients with hypertension. Almotriptan malate is contraindicated in patients who have had a stroke or transient ischemic</p>Fórmula:C17H25N3O2S•C4H6O5Pureza:Min. 95%Forma y color:SolidPeso molecular:469.55 g/molAlmotriptan Malate
CAS:<p>Applications Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.<br>References Fleishaker, J.C., et al.: Clin. Pharmacol. Ther., 67, 498 (2000), Kamali, F., et al.: Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs, 2, 197 (2000), Dodick, D.W., et al.: Expert Opin.Pharmacother., 4, 1157 (2003)<br></p>Fórmula:C17H25N3O2S·C4H6O5Forma y color:NeatPeso molecular:469.55
![Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indol…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0022QH.jpg&w=3840&q=75)
