CAS 181183-52-8

Almotriptán malato

Descripción:

Almotriptán malato es un compuesto farmacéutico utilizado principalmente en el tratamiento de las migrañas. Pertenece a la clase de medicamentos triptanes, que están diseñados específicamente para aliviar los síntomas de la migraña actuando como agonistas en los receptores de serotonina, particularmente en los subtipos 5-HT_1B y 5-HT_1D. Esta acción conduce a la vasoconstricción de los vasos sanguíneos craneales y a la inhibición de la liberación de neuropeptidos proinflamatorios. El almotriptán se caracteriza por su relativamente alta biodisponibilidad oral y un perfil farmacocinético favorable, que incluye una vida media moderada que permite un manejo efectivo de los ataques agudos de migraña. La forma de sal de malato mejora su solubilidad y estabilidad, facilitando la absorción en el tracto gastrointestinal. El almotriptán generalmente es bien tolerado, aunque puede causar efectos secundarios como mareos, fatiga o sensaciones de hormigueo. Al igual que otros triptanes, está contraindicado en pacientes con ciertas condiciones cardiovasculares debido al potencial de vasoconstricción. En general, Almotriptán malato representa una opción importante en el arsenal terapéutico para el manejo de la migraña.

Fórmula: C₁₇H₂₅N₃O₂S·C₄H₆O₅

InChI: InChI=1/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)

Clave InChI: InChIKey=QHATUKWEVNMHRY-UHFFFAOYSA-N

SMILES: C(CN(C)C)C=1C=2C(NC1)=CC=C(CS(=O)(=O)N3CCCC3)C2.C(CC(O)=O)(C(O)=O)O

Sinónimos:

• 1-[[3-(2-Dimethylaminoethyl)-5-Indolyl]Methanesulphonyl]Pyrrolidine Malate
• 1-[[[2-(Dimethyl-Amino)Ethyl]-1H-Indol-5-Yl]Methyl]Sulfonyl]Pyrrolidine Malate
• 2-hydroxybutanedioic acid - N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (1:1)
• Almotrip forte
• Almotriptan Malate
• Almotriptan Maleate
• Almotriptanmaleate
• Axert
• Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
• Butanedioic acid, hydroxy-, compd with 1-[[[3-[2-(dimethylamino)ethyl]-1h-indol-5-yl]methyl]sulfonyl]pyrrolidine
• Butanedioic acid, hydroxy-, compd. with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine (1:1)
• LAS 31416 <span class="text-smallcaps">D</smallcap>,<smallcap>L</span>-malate acid
• Las-31416 Malate
• N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine
• Pnu 180638
• Pnu 180638E
• Pyrrolidine, 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]-, hydroxybutanedioate (1:1)
• LAS 31416 D,L-malate acid
• hydroxy-Butanedioic acid, compd.with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine(1:1)(9CI)
• N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine,compd. with 2-hydroxy-butanedioic acid
• Almotriptan
• AlMotriptan Malate (Axert)
• Amotriptan malate
• 1-[[[3-[2-(dimeth
• See: A575201
• 2-Hydroxy-butanedioic acid, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
• Almotriptan Malate (200 mg)

Almotriptan Malate

CAS: 181183-52-8

Fórmula: C₁₇H₂₅N₃O₂SC₄H₆O₅

Peso molecular: 335.47 : 134.09

Ref: ST-EA-CP-A53037

ALMOTRIPTAN MALATE CRS

CAS: 181183-52-8

ALMOTRIPTAN MALATE CRS

Ref: 41-Y0002144

Almotriptan Malate

CAS: 181183-52-8

Sulfonamides used as drugs

Fórmula: C₁₇H₂₅N₃O₂S·C₄H₆O₅

Forma y color: White Off-White Crystalline Powder

Peso molecular: 335.16675

Ref: 45-1013512

Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)

CAS: 181183-52-8

Fórmula: C₂₁H₃₁N₃O₇S

Pureza: 98%

Forma y color: Solid

Peso molecular: 469.5517

Ref: IN-DA0022QH

Almotriptan-d6 Malate

CAS: 181183-52-8

Fórmula: C₁₇H₁₉D₆N₃O₂S·C₄H₆O₅

Forma y color: White To Off-White Solid

Peso molecular: 341.50 134.09

Ref: 4Z-A-051

Almotriptan Malate

CAS: 181183-52-8

Almotriptan Malate

Pureza: ≥98%

Peso molecular: 469.55g/mol

Ref: 54-BUP14171

Almotriptan Malate

CAS: 181183-52-8

Fórmula: C₁₇H₂₅N₃O₂S·C₄H₆O₅

Forma y color: Pale Yellow Solid

Peso molecular: 335.47 134.09

Ref: 4Z-A-052

Almotriptan malate

CAS: 181183-52-8

Fórmula: C₂₁H₃₁N₃O₇S

Peso molecular: 469.55

Ref: 7W-GP9851

Almotriptan Malate

CAS: 181183-52-8

Forma y color: Neat

Ref: 86-MM3978.00

Almotriptan Malate

CAS: 154323-57-6, 181183-52-8

Fórmula: C₁₇H₂₅N₃O₂S·C₄H₆O₅

Pureza: >98.0%(HPLC)

Forma y color: White to Orange to Green powder to crystal

Peso molecular: 469.55

Ref: 3B-A3111

Almotriptan Malate

CAS: 181183-52-8

Almotriptan Malate (PNU180638), a selective 5-HT1B/1D receptor agonist, is used in the therapy of Migraine attacks in adults.

Fórmula: C₁₇H₂₅N₃O₂S·C₄H₆O₅

Pureza: 99.95%

Forma y color: Pale Yellow Solid

Peso molecular: 469.55

Ref: TM-T2317

Almotriptan malate

CAS: 181183-52-8

Almotriptan malate is a serotonin 1B/1D receptor agonist that is used as an anti-migraine drug, specifically for the treatment of migraine headaches with or without aura. It has been shown to cause regression of angiogenic factors and statistically significant improvement in migraine headache frequency, severity, and duration when taken within 24 hours of onset of a migraine. Almotriptan malate can be administered by nasal spray or oral tablets. The recommended dose for adults is 25-50 mg (1-2 tablets) taken at the first sign of a headache. Almotriptan malate should not be given to people who have liver impairment or are taking sodium carbonate. Side effects may include nasal congestion, dizziness, dry mouth, nausea, vomiting, and diarrhea. Almotriptan malate should be used with caution in patients with hypertension. Almotriptan malate is contraindicated in patients who have had a stroke or transient ischemic

Fórmula: C₁₇H₂₅N₃O₂S•C₄H₆O₅

Pureza: Min. 95%

Forma y color: Solid

Peso molecular: 469.55 g/mol

Ref: 3D-FA33641

Almotriptan Malate

CAS: 181183-52-8

Applications Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.
References Fleishaker, J.C., et al.: Clin. Pharmacol. Ther., 67, 498 (2000), Kamali, F., et al.: Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs, 2, 197 (2000), Dodick, D.W., et al.: Expert Opin.Pharmacother., 4, 1157 (2003)

Fórmula: C₁₇H₂₅N₃O₂S·C₄H₆O₅

Forma y color: Neat

Peso molecular: 469.55

Ref: TR-A575200